Grtpa and international normalised ratio decreased Patient Reports February 12, 2012

Grtpa Side Effects Report #5170156-4
Grtpa side effect was reported by a Health Professional from JAPAN on Nov 28, 2006. Female patient, 81 years of age, was diagnosed with cerebral infarction and was treated with Grtpa. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, cardiac disorder, cardio-respiratory arrest, haematocrit decreased, international normalised ratio decreased, ventricular tachycardia. Grtpa dosage: 39.4 MG, SINGLE, INTRAVENOUS. During the same period patient was treated with RADICUT. Patient died on 09/29/2006.

Grtpa Side Effects Report #5258251-2
Grtpa side effect was reported by a Health Professional from JAPAN on Feb 28, 2007. Female patient, 80 years of age, was diagnosed with cerebral infarction and was treated with Grtpa. After drug was administered, patient experienced the following side effects: brain oedema, haematocrit decreased, haemoglobin decreased, international normalised ratio decreased, no therapeutic response, platelet count decreased, red blood cell count decreased. Grtpa dosage: 30.1 MG, SINGLE, INTRAVENOUS. During the same period patient was treated with WARFARIN, RADICUT, ZANTAC. Patient died on 02/15/2007.

Grtpa Side Effects Report #5232301-1
Grtpa side effect was reported by a Physician from JAPAN on Jan 29, 2007. Male patient, 72 years of age, was diagnosed with cerebral infarction and was treated with Grtpa. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, cerebral infarction, condition aggravated, depressed level of consciousness, infection , international normalised ratio decreased, pneumonia aspiration. Grtpa dosage: unknown. During the same period patient was treated with CEFTAZIDIME, RADICUT, DILTIAZEM. Patient was hospitalized. Patient recovered.

Grtpa Side Effects Report #5291105-4
Grtpa side effect was reported by a Health Professional from JAPAN on Mar 28, 2007. Female patient, 57 years of age, was diagnosed with cerebral infarction and was treated with Grtpa. After drug was administered, patient experienced the following side effects: blood glucose increased, blood pressure decreased, brain stem infarction, depressed level of consciousness, haematocrit decreased, hemiplegia, international normalised ratio decreased, platelet count decreased, pneumonia . Grtpa dosage: 29 ML SINGLE INTRAVENOUS. During the same period patient was treated with LACTATED RINGER, ARGATROBAN, DOPAMINE HYDROCHLORIDE, PIPERACILLIN, RADICUT, ISOTONIC SOLUTION. Patient died on 09/26/2006.