Elaprase and brain stem auditory evoked response abnormal Patient Reports February 13, 2012

Elaprase Side Effects Report #6055010-8
Elaprase side effect was reported by a Physician from JAPAN on Jan 08, 2009. Male patient, 16 years of age, weighting 48.50 lb, was diagnosed with mucopolysaccharidosis ii and was treated with Elaprase. After drug was administered, patient experienced the following side effects: brain stem auditory evoked response abnormal, bronchitis , epilepsy , pulmonary valve incompetence, tricuspid valve incompetence, urticaria. Elaprase dosage: 11.2 MG, 1X/WEEK, IV DRIP. During the same period patient was treated with CHLORPHENIRAMINE MALEATE. Patient recovered.

Elaprase Side Effects Report #6077370-4
Elaprase side effect was reported by a Physician from JAPAN on Jan 30, 2009. Male patient, 16 years of age, weighting 48.50 lb, was diagnosed with mucopolysaccharidosis ii and was treated with Elaprase. After drug was administered, patient experienced the following side effects: brain stem auditory evoked response abnormal, convulsion. Elaprase dosage: 11.2 MG, 1X/WEEK, IV DRIP. During the same period patient was treated with CHLORPHENIRAMINE MALEATE. Patient recovered.

Elaprase Side Effects Report #6053626-6
Elaprase side effect was reported by a Physician from JAPAN on Jan 08, 2009. Male patient, 15 years of age, weighting 48.50 lb, was diagnosed with mucopolysaccharidosis ii and was treated with Elaprase. After drug was administered, patient experienced the following side effects: brain stem auditory evoked response abnormal, bronchitis , convulsion, epilepsy , infusion related reaction, pulmonary valve incompetence, tricuspid valve incompetence. Elaprase dosage: 11.2 MG, 1X/WEEK, IV DRIP. During the same period patient was treated with CHLORPHENIRAMINE MALEATE. Patient recovered.