Diovan and blood pressure increased Patient Reports February 10, 2012
Diovan Side Effects Report #5480305-6
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on Feb 13, 2007. Female patient, 90 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood potassium increased, blood pressure increased. Diovan dosage: 80 MG, QD, ORAL; 160 MG, QD, ORAL. During the same period patient was treated with LASIX, CLONIDINE. Patient was hospitalized. Patient recovered.
Diovan Side Effects Report #5754077-1
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on May 23, 2008. Female patient, 88 years of age, weighting 172.0 lb, was diagnosed with hypertension, cerebrovascular accident prophylaxis, osteoporosis
, osteopenia, bone pain, arrhythmia
and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood glucose increased, blood pressure increased. Diovan dosage: 160 MG, QD. During the same period patient was treated with CALCIUM SANDOZ, CALCIUM SANDOZ, ALENDRONATE, VOLTAREN, RYTHMOL. Patient was hospitalized. Patient recovered.Diovan Side Effects Report #5268096-5
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on Nov 06, 2006. Female patient, 87 years of age, weighting 120.0 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, dizziness
, speech disorder, syncope, visual disturbance. Diovan dosage: 160 MG, QD. During the same period patient was treated with HYDROCHLOROTHIAZIDE, METOPROLOL BY MYLAN, DILTIAZEM, VERAPAMIL, LISINOPRIL. Patient was hospitalized. Patient recovered.Diovan Side Effects Report #5061887-5
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on July 18, 2006. Female patient, 87 years of age, weighting 120.0 lb, was diagnosed with hypertension, hypothyroidism and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, dizziness
, loss of consciousness, syncope. Diovan dosage: 160 MG, QD. During the same period patient was treated with HYDROCHLOROTHIAZIDE, METOPROLOL BY MYLAN, DILTIAZEM, VERAPAMIL, LISINOPRIL, TERAZOSIN, SYNTHROID. Patient was hospitalized. Patient recovered.Diovan Side Effects Report #5140912-7
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on Mar 31, 2006. Female patient, 86 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, hypersensitivity, lip disorder, pharyngeal oedema, rash
, swelling face. Diovan dosage: 80 MG,QD, ORAL. During the same period patient was treated with DIOVAN HCT. Patient recovered.Diovan Side Effects Report #4657835-X
Diovan side effect was reported by a Consumer or non-health professional from on Feb 28, 2005. Female patient, 86 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: asthenia, blood pressure increased, difficulty in walking, dizziness
, headache
. Diovan dosage: unknown. During the same period patient was treated with MECLIZINE, ARICEPT, VITAMINS. Patient recovered.Diovan Side Effects Report #5031515-3
Diovan side effect was reported by a Physician from UNITED STATES on Apr 25, 2005. Female patient, 86 years of age, weighting 138.0 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: asthenia, blood pressure increased, difficulty in walking, dizziness
, headache
, malaise. Diovan dosage: unknown. During the same period patient was treated with MECLIZINE, ARICEPT, VITAMNS. Patient recovered.Diovan Side Effects Report #5621750-5
Diovan side effect was reported by a Physician from PERU on Jan 31, 2008. Female patient, 85 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, tachycardia. Diovan dosage: 160 MG, BID. Patient recovered.
Diovan Side Effects Report #5238124-1
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on Feb 02, 2007. Female patient, 84 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: arrhythmia
, blood pressure increased. Diovan dosage: VLAS 160 / AMLO 5 MG/DAY. During the same period patient was treated with SOMALGIN, LASIX, DAFLON. Patient was hospitalized. Patient recovered.Diovan Side Effects Report #5262204-8
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on Feb 27, 2007. Female patient, 84 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: arrhythmia
, blood pressure increased. Diovan dosage: VLAS 160 / AMLO 5 MG/DAY. During the same period patient was treated with SOMALGIN, LASIX, DAFLON. Patient was hospitalized. Patient recovered.Diovan Side Effects Report #5349409-2
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on May 19, 2006. Female patient, 84 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure decreased, blood pressure increased, dizziness
, ear pain, tinnitus
. Diovan dosage: 80 MG VAL/12.5MG HCT, QD, ORAL. Patient recovered.Diovan Side Effects Report #5140910-3
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on Feb 28, 2006. Female patient, 84 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased. Diovan dosage: unknown. Patient recovered.
Diovan Side Effects Report #5015399-5
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on May 19, 2006. Female patient, 84 years of age, was diagnosed with hypertension, asthma
and was treated with Diovan. After drug was administered, patient experienced the following side effects: asthma
, blood pressure increased, diabetes mellitus, diabetes mellitus inadequate control. Diovan dosage: 80 MG, QD. During the same period patient was treated with HYDROCHLOROTHIAZIDE, PREDNISONE, IMDUR, LIPITOR, ASPIRIN, ZANTAC. Patient recovered.Diovan Side Effects Report #5724164-2
Diovan side effect was reported by a Pharmacist from JAPAN on Apr 28, 2008. Female patient, 83 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, chills, tremor. Diovan dosage: 40 MG, BID. Patient was hospitalized. Patient recovered.
Diovan Side Effects Report #5756030-0
Diovan side effect was reported by a Pharmacist from JAPAN on May 23, 2008. Female patient, 83 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, chills, tremor. Diovan dosage: 40 MG, BID. Patient was hospitalized. Patient recovered.
Diovan Side Effects Report #5796427-6
Diovan side effect was reported by a Pharmacist from JAPAN on June 17, 2008. Female patient, 83 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, chills, tremor. Diovan dosage: 40 MG, BID. Patient was hospitalized. Patient recovered.
Diovan Side Effects Report #6100875-4
Diovan side effect was reported by a Consumer or non-health professional from GERMANY on Feb 18, 2009. Female patient, 83 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: abasia, back pain
, blood pressure increased, limb discomfort, myalgia. Diovan dosage: 160/12.5 MG. Patient recovered.Diovan Side Effects Report #6121012-6
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on Mar 07, 2009. Female patient, 83 years of age, was diagnosed with hypertension, hypothyroidism, blood calcium and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, breast mass, surgery
. Diovan dosage: ONE TABLET (80/12.5 MG) DAILY. During the same period patient was treated with DIOVAN HCT, PURAN T, CALCIUM. Patient recovered.Diovan Side Effects Report #4788176-8
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 16, 2004. Female patient, 83 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased. Diovan dosage: 160 MG, BID, ORAL; SEE IMAGE. During the same period patient was treated with CAPTOPRIL, DIURETICS, VITAMINS. Patient was hospitalized. Patient recovered.
Diovan Side Effects Report #5137022-1
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on June 01, 2006. Male patient, 82 years of age, was diagnosed with hypertension, gastrooesophageal reflux disease, arthritis
, blood cholesterol increased and was treated with Diovan. After drug was administered, patient experienced the following side effects: adenoma benign, blood pressure increased, insomnia. Diovan dosage: 80 MG, QD. During the same period patient was treated with NEXIUM, CELEBREX, PRAVACHOL. Patient recovered.Diovan Side Effects Report #5020964-5
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on June 01, 2006. Male patient, 82 years of age, was diagnosed with hypertension, gastrooesophageal reflux disease, arthritis
, blood cholesterol increased and was treated with Diovan. After drug was administered, patient experienced the following side effects: adenoma benign, blood pressure increased, insomnia. Diovan dosage: 80 MG, QD. During the same period patient was treated with NEXIUM, CELEBREX, PRAVACHOL. Patient recovered.Diovan Side Effects Report #5140919-X
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 01, 2006. Female patient, 81 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased. Diovan dosage: unknown. Patient recovered.
Diovan Side Effects Report #5480296-8
Diovan side effect was reported by a Physician from UNITED STATES on Oct 03, 2006. Female patient, 81 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: arthralgia, blood pressure increased. Diovan dosage: 80 MG, QD, ORAL 160 MG, QD, ORAL. During the same period patient was treated with ANTIHISTAMINES. Patient recovered.
Diovan Side Effects Report #4603260-7
Diovan side effect was reported by a Consumer or non-health professional from on May 26, 2004. Female patient, 81 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased. Diovan dosage: unknown. Patient recovered.
Diovan Side Effects Report #5662183-5
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on Sept 19, 2007. Female patient, 79 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased. Diovan dosage: 160 MG, QD, ORAL. Patient recovered.
Diovan Side Effects Report #5990668-0
Diovan side effect was reported by a Consumer or non-health professional from MEXICO on Dec 02, 2008. Female patient, 79 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, surgery
, thrombosis. Diovan dosage: 1 TABLET (160/12.5 MG) PER DAY. During the same period patient was treated with DIOVAN HCT. Patient was hospitalized. Patient recovered.Diovan Side Effects Report #4788175-6
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on July 21, 2004. Female patient, 79 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased. Diovan dosage: 320 MG, QD, ORAL; SEE IMAGE. During the same period patient was treated with CALCIUM, VITAMIN E, ASPIRIN, METAMUCIL. Patient recovered.
Diovan Side Effects Report #4788223-3
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on July 16, 2004. Female patient, 79 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, dry mouth, stress
. Diovan dosage: 80 MG, QD, ORAL; 160 MG, QD, ORAL. During the same period patient was treated with HYDROCHLOROTHIAZIDE. Patient recovered.Diovan Side Effects Report #5368179-5
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on June 12, 2007. Female patient, 78 years of age, weighting 198.4 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: abasia, blood pressure increased, cerebellar tumour, diplegia, dysarthria, paresis, somnolence, tumour excision. Diovan dosage: 160 MG/DAILY. During the same period patient was treated with AMLODIPINE BESYLATE, CILOSTAZOL, CLONIDINE. Patient was hospitalized. Patient recovered.
Diovan Side Effects Report #5140906-1
Diovan side effect was reported by a Physician from UNITED STATES on Jan 11, 2006. Female patient, 78 years of age, weighting 183.0 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood creatinine increased, blood potassium increased, blood pressure increased, blood urea increased, carbon dioxide decreased, eating disorder
. Diovan dosage: 80 MG,QD, ORAL. During the same period patient was treated with PREVACID, ZOLOFT, ALDACTAZIDE, LEVOXYL. Patient recovered.Diovan Side Effects Report #5479536-0
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on Dec 31, 2006. Male patient, 78 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, hypertension. Diovan dosage: 80 MG, QD. During the same period patient was treated with ASPIRIN, LOPRESSOR. Patient recovered.
Diovan Side Effects Report #4788198-7
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on May 24, 2005. Male patient, 78 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased. Diovan dosage: unknown. Patient recovered.
Diovan Side Effects Report #4788207-5
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on July 06, 2005. Female patient, 78 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased. Diovan dosage: 160 MG, QD, ORAL. During the same period patient was treated with NORVASC, COREG, PRANDIN, HUMULIN, LIPITOR, SYNTHROID, DIGOXIN, XANAX. Patient recovered.
Diovan Side Effects Report #6016663-3
Diovan side effect was reported by a Physician from JAPAN on Dec 17, 2008. Male patient, 76 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: arrhythmia
, blood pressure increased, brain natriuretic peptide increased, international normalised ratio increased. Diovan dosage: 80 MG, QD. During the same period patient was treated with ASPIRIN, HERBESSER, BEPRICOR, DICHLOTRIDE. Patient died on 12/11/2008.Diovan Side Effects Report #4733569-8
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on July 27, 2005. Female patient, 76 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, heart rate increased. Diovan dosage: 80 MG, QD. Patient recovered.
Diovan Side Effects Report #5146941-1
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on June 07, 2006. Female patient, 75 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure decreased, blood pressure increased, headache
. Diovan dosage: unknown. During the same period patient was treated with METOPROLOL TARTRATE, NORVASC. Patient recovered.Diovan Side Effects Report #6025266-6
Diovan side effect was reported by a Physician from BELGIUM on Dec 18, 2008. Female patient, 75 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, cervix carcinoma, colectomy, colostomy, female genital tract fistula, hypertension. Diovan dosage: 160/12.5 MG DAILY. During the same period patient was treated with ASPIRIN, DAFALGAN, CEDOCARD. Patient recovered.
Diovan Side Effects Report #6120404-9
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on Mar 06, 2009. Female patient, 75 years of age, was diagnosed with hypertension, blood cholesterol increased and was treated with Diovan. After drug was administered, patient experienced the following side effects: bladder operation, blood pressure increased, stress urinary incontinence, type 2 diabetes mellitus. Diovan dosage: unknown. During the same period patient was treated with HYPERIUM, CRESTOR, COLPOTROFIN. Patient recovered.
Diovan Side Effects Report #4700296-2
Diovan side effect was reported by a Consumer or non-health professional from on June 20, 2005. Female patient, 75 years of age, weighting 163.1 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: asthenia, blood pressure fluctuation, blood pressure increased, headache
, heart rate increased, tremor. Diovan dosage: 80 MG, QD. During the same period patient was treated with CLONIDINE. Patient recovered.Diovan Side Effects Report #4757424-2
Diovan side effect was reported by a Physician from UNITED STATES on June 20, 2005. Female patient, 75 years of age, weighting 163.1 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: asthenia, atrial fibrillation
, atrial flutter, atrioventricular block, blood pressure fluctuation, blood pressure increased, cardiac murmur, headache
, heart rate irregular. Diovan dosage: 80 MG, QD. During the same period patient was treated with CLONIDINE. Patient recovered.Diovan Side Effects Report #5480313-5
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on Mar 19, 2007. Male patient, 74 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, myalgia. Diovan dosage: 320 MG, QD; 160 M G, QD; 320 MG, QD. Patient recovered.
Diovan Side Effects Report #4658164-0
Diovan side effect was reported by a Consumer or non-health professional from on July 20, 2004. Female patient, 74 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, fatigue. Diovan dosage: unknown. During the same period patient was treated with DIOVAN HCT, POTASSIUM ACETATE, VIOXX. Patient recovered.
Diovan Side Effects Report #5366422-X
Diovan side effect was reported by a Physician from JAPAN on June 15, 2007. Female patient, 73 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: ascites, blood pressure increased, fall
, oedema, rib fracture. Diovan dosage: 80 MG, BID. During the same period patient was treated with THYRADIN, NEUROVITAN, FRANDOL, LIPIDIL, NOVORAPID. Patient was hospitalized. Patient recovered.Diovan Side Effects Report #5386208-X
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on July 02, 2007. Female patient, 73 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, cataract
, cataract operation, muscle disorder
. Diovan dosage: 320 MG, QD. During the same period patient was treated with GINKGO BILOBA, CHLORTHALIDONE. Patient recovered.Diovan Side Effects Report #5393327-0
Diovan side effect was reported by a Physician from GERMANY on July 17, 2007. Female patient, 73 years of age, weighting 147.7 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: alopecia, arthropathy, asthenia, blood pressure increased, erythema, fatigue, hormone level abnormal, hypohidrosis, immune system disorder. Diovan dosage: unknown. During the same period patient was treated with ANTIBIOTICS. Patient recovered.
Diovan Side Effects Report #5476875-4
Diovan side effect was reported by a Physician from GERMANY on Oct 01, 2007. Female patient, 73 years of age, weighting 147.7 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: alopecia, arthropathy, asthenia, blood pressure increased, erythema, fatigue, hormone level abnormal, hypohidrosis. Diovan dosage: unknown. During the same period patient was treated with ANTIBIOTICS. Patient recovered.
Diovan Side Effects Report #5476876-6
Diovan side effect was reported by a Physician from GERMANY on Oct 01, 2007. Female patient, 73 years of age, weighting 147.7 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: alopecia, arthropathy, asthenia, blood pressure increased, erythema, fatigue, hormone level abnormal, hypohidrosis. Diovan dosage: unknown. During the same period patient was treated with ANTIBIOTICS. Patient recovered.
Diovan Side Effects Report #5479318-X
Diovan side effect was reported by a Physician from JAPAN on Sept 28, 2007. Female patient, 73 years of age, weighting 125.7 lb, was diagnosed with hypertension, hypothyroidism, angina pectoris, hyperlipidaemia and was treated with Diovan. After drug was administered, patient experienced the following side effects: ascites, aspartate aminotransferase increased, blood glucose increased, blood lactate dehydrogenase increased, blood pressure increased, blood uric acid increased, c-reactive protein increased, cough, fall
. Diovan dosage: 80 MG, BID. During the same period patient was treated with THYRADIN, NEUROVITAN, FRANDOL, LIPIDIL, NOVORAPID. Patient was hospitalized. Patient recovered.Diovan Side Effects Report #5792027-2
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on June 16, 2008. Female patient, 73 years of age, weighting 154.3 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, nervousness, surgery
, varicose vein
, varicose vein ruptured. Diovan dosage: unknown. Patient recovered.Diovan Side Effects Report #5906124-1
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on Sept 25, 2008. Female patient, 73 years of age, weighting 154.3 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, nervousness, surgery
, varicose vein
, varicose vein ruptured, weight decreased. Diovan dosage: unknown. Patient recovered.Diovan Side Effects Report #6106265-2
Diovan side effect was reported by a Consumer or non-health professional from GERMANY on Feb 23, 2009. Male patient, 73 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure decreased, blood pressure inadequately controlled, blood pressure increased, eye operation, retinal disorder
. Diovan dosage: unknown. During the same period patient was treated with ANDANTE, DYNACIL, INSULIN ACTRAPID, INSULIN PROTAPHANE. Patient recovered.Diovan Side Effects Report #4761442-8
Diovan side effect was reported by a Consumer or non-health professional from COLOMBIA on Aug 25, 2005. Male patient, 73 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: back pain
, blood pressure increased, dyspnoea, pulmonary oedema, speech disorder. Diovan dosage: 2 DF, 160/12.5 MG, QD. During the same period patient was treated with PLAVIX, METOPROLOL. Patient was hospitalized. Patient recovered.Diovan Side Effects Report #4767197-5
Diovan side effect was reported by a Consumer or non-health professional from COLOMBIA on Aug 25, 2005. Male patient, 73 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: back pain
, blood pressure increased, catheterisation cardiac, dyspnoea, pulmonary oedema, speech disorder, stent placement. Diovan dosage: VAL 160 / HCT 12.5 MG, QD. During the same period patient was treated with PLAVIX, METOPROLOL, BAYPRESS. Patient was hospitalized. Patient recovered.Diovan Side Effects Report #4769907-X
Diovan side effect was reported by a Consumer or non-health professional from COLOMBIA on Aug 25, 2005. Male patient, 73 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: back pain
, blood pressure increased, catheterisation cardiac, dyspnoea, pulmonary oedema, speech disorder, stent placement. Diovan dosage: TWO TABLETS OF VAL 160 / HCT 12.5 MG DAILY. During the same period patient was treated with PLAVIX, METOPROLOL, BAYPRESS. Patient was hospitalized. Patient recovered.Diovan Side Effects Report #4778114-6
Diovan side effect was reported by a Consumer or non-health professional from COLOMBIA on Aug 25, 2005. Male patient, 73 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: back pain
, blood pressure increased, catheterisation cardiac, dyspnoea, pulmonary oedema, speech disorder, stent placement. Diovan dosage: TWO TABLETS OF VAL 160 / HCT 12.5 MG DAILY. During the same period patient was treated with PLAVIX, METOPROLOL, BAYPRESS. Patient was hospitalized. Patient recovered.Diovan Side Effects Report #5589252-2
Diovan side effect was reported by a Consumer or non-health professional from on Jan 03, 2008. Female patient, 72 years of age, weighting 180.8 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blister, blood pressure increased, erythema, oedema peripheral, scleroderma
, skin discolouration, wound
. Diovan dosage: 160 MG, UNK. During the same period patient was treated with EXFORGE. Patient recovered.Diovan Side Effects Report #5691790-9
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on Mar 21, 2008. Female patient, 72 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, eye haemorrhage, eye swelling, vision blurred. Diovan dosage: unknown. During the same period patient was treated with CARDIZEM, MOTRIN, ASPIRIN. Patient was hospitalized. Patient recovered.
Diovan Side Effects Report #5692233-1
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on Mar 21, 2008. Female patient, 72 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, eye haemorrhage, eye swelling, vision blurred. Diovan dosage: unknown. During the same period patient was treated with CARDIZEM, MOTRIN, ASPIRIN. Patient was hospitalized. Patient recovered.
Diovan Side Effects Report #5730104-2
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on Apr 29, 2008. Female patient, 72 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, eye haemorrhage, eye swelling, vision blurred. Diovan dosage: unknown. During the same period patient was treated with CARDIZEM, MOTRIN, ASPIRIN. Patient was hospitalized. Patient recovered.
Diovan Side Effects Report #5922529-7
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on Oct 08, 2008. Female patient, 72 years of age, was diagnosed with hypertension, osteoporosis
, cardiovascular disorder and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure fluctuation, blood pressure increased, disorientation, dizziness
, headache
. Diovan dosage: unknown. During the same period patient was treated with ALENDRONATE, GINKGO BILOBA. Patient recovered.Diovan Side Effects Report #6057780-1
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on Jan 23, 2009. Female patient, 72 years of age, weighting 149.9 lb, was diagnosed with hypertension, blood cholesterol abnormal, dyspnoea, cardiac disorder, cardiovascular disorder, depression
, diabetes mellitus, labyrinthitis and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, headache
, labyrinthitis, retching. Diovan dosage: 80/12.5 MG DAILY. During the same period patient was treated with SIMVASTATIN, SERETIDE, GLICLAZIDE, GINKGO BILOBA, BUPROPION HYDROCHLORIDE, METFORMIN HYDROCHLORIDE, BETASERC. Patient recovered.Diovan Side Effects Report #4717984-4
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on July 12, 2005. Female patient, 72 years of age, weighting 176.4 lb, was diagnosed with hypertension, nervous system disorder, depression
and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, heart rate increased. Diovan dosage: unknown. During the same period patient was treated with ZACON, LEXEL, CLONAZEPAM. Patient recovered.Diovan Side Effects Report #5448265-1
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on Sept 04, 2007. Female patient, 71 years of age, weighting 154.3 lb, was diagnosed with hypertension, gastritis, blood glucose increased and was treated with Diovan. After drug was administered, patient experienced the following side effects: aortic calcification, arthralgia, arthropathy, blood glucose increased, blood pressure increased, headache
, joint injury, knee operation, muscle atrophy. Diovan dosage: 80 MG/DAY. During the same period patient was treated with OMEPRAZOLE, VERAPAMIL, DAFLON, METFORMIN. Patient recovered.Diovan Side Effects Report #5458033-2
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on Sept 08, 2007. Female patient, 71 years of age, weighting 154.3 lb, was diagnosed with hypertension, gastritis, blood glucose increased and was treated with Diovan. After drug was administered, patient experienced the following side effects: aortic calcification, arthralgia, arthropathy, blood glucose increased, blood pressure increased, headache
, joint injury, knee operation. Diovan dosage: 80 MG/DAY. During the same period patient was treated with OMEPRAZOLE, VERAPAMIL, DAFLON, METFORMIN. Patient recovered.Diovan Side Effects Report #5524745-5
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on Nov 19, 2007. Female patient, 71 years of age, weighting 134.5 lb, was diagnosed with hypertension, hiatus hernia and was treated with Diovan. After drug was administered, patient experienced the following side effects: abdominal distension, blood pressure decreased, blood pressure increased, eructation, gastrooesophageal reflux disease, muscle contractions involuntary, muscle spasms, myoclonus, regurgitation. Diovan dosage: 160/ 5 MG TABLET. During the same period patient was treated with DIOVAN AMLO FIX, DIOVAN AMLO FIX, OMEPRAZOLE. Patient recovered.
Diovan Side Effects Report #5545287-7
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on Dec 04, 2007. Male patient, 71 years of age, weighting 132.3 lb, was diagnosed with hypertension, hyperthyroidism, blood cholesterol increased and was treated with Diovan. After drug was administered, patient experienced the following side effects: bacterial infection
, blood pressure increased, renal disorder. Diovan dosage: 80 MG, QD. During the same period patient was treated with MONOCORTIN, PURAN T, ASPIRIN, LASIX, ZOCOR, UNOPROST. Patient recovered.Diovan Side Effects Report #5140924-3
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on Dec 19, 2005. Female patient, 70 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased. Diovan dosage: unknown. During the same period patient was treated with LOPRESSOR, EFFEXOR, ZOCOR, PREMARIN. Patient was hospitalized. Patient recovered.
Diovan Side Effects Report #5988676-9
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on Dec 01, 2008. Female patient, 70 years of age, weighting 186.1 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, erythema, feeling abnormal, haematoma, hypersensitivity, pruritus, skin discolouration. Diovan dosage: 80/12.5 MG, 1 TAB/MORNING. During the same period patient was treated with DIOVAN HCT, ATENOLOL. Patient recovered.
Diovan Side Effects Report #4732675-1
Diovan side effect was reported by a Physician from UNITED STATES on July 22, 2005. Male patient, 70 years of age, weighting 224.9 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: biopsy, blood pressure fluctuation, blood pressure increased, lung neoplasm malignant. Diovan dosage: unknown. Patient was hospitalized. Patient recovered.
Diovan Side Effects Report #4734895-9
Diovan side effect was reported by a Physician from UNITED STATES on July 22, 2005. Male patient, 70 years of age, weighting 224.9 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: biopsy, blood pressure fluctuation, blood pressure increased, lung neoplasm malignant. Diovan dosage: unknown. Patient was hospitalized. Patient recovered.
Diovan Side Effects Report #4785980-7
Diovan side effect was reported by a Physician from UNITED STATES on July 22, 2005. Male patient, 70 years of age, weighting 224.9 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: biopsy, blood pressure fluctuation, blood pressure increased, lung neoplasm malignant. Diovan dosage: unknown. Patient was hospitalized. Patient recovered.
Diovan Side Effects Report #4801118-1
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on Oct 07, 2005. Female patient, 70 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, heart rate increased, middle insomnia, sleep disorder
. Diovan dosage: 80 MG, QD. Patient recovered.Diovan Side Effects Report #4816536-5
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on Oct 07, 2005. Female patient, 70 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, heart rate increased, sleep disorder
. Diovan dosage: 80 MG, QD. Patient recovered.Diovan Side Effects Report #4909058-4
Diovan side effect was reported by a Physician from GUATEMALA on Jan 31, 2006. Female patient, 70 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, dizziness
, extrasystoles, palpitations. Diovan dosage: VALS 160 / HCT 25 MG/DAY. During the same period patient was treated with CONCOR. Patient was hospitalized. Patient recovered.Diovan Side Effects Report #5347541-0
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on Dec 04, 2006. Male patient, 69 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, hypotension. Diovan dosage: unknown. Patient recovered.
Diovan Side Effects Report #5187702-7
Diovan side effect was reported by a Consumer or non-health professional from UNITED KINGDOM on Nov 22, 2006. Female patient, 68 years of age, weighting 182.0 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure decreased, blood pressure increased, joint swelling. Diovan dosage: 40 MG, QD. During the same period patient was treated with NATRILIX, ASPIRIN, LIPITOR. Patient recovered.
Diovan Side Effects Report #5486281-4
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on Oct 05, 2007. Female patient, 68 years of age, weighting 183.0 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: arrhythmia
, blood pressure increased, chest pain
, electrocardiogram abnormal, venous occlusion. Diovan dosage: 160/25MG DAILY. During the same period patient was treated with PROPRANOLOL, ASPIRIN, VENLAFAXINE, RISETRONATE, LIPITOR. Patient recovered.Diovan Side Effects Report #5498613-1
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on Oct 17, 2007. Female patient, 68 years of age, weighting 183.0 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: arrhythmia
, blood pressure increased, chest pain
, electrocardiogram abnormal, venous occlusion. Diovan dosage: 160/25MG DAILY. During the same period patient was treated with PROPRANOLOL, ASPIRIN, VENLAFAXINE, RISETRONATE, LIPITOR. Patient recovered.Diovan Side Effects Report #6050488-8
Diovan side effect was reported by a Physician from on Jan 14, 2009. Male patient, 68 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure fluctuation, blood pressure increased, disturbance in attention, dizziness
, hypertensive crisis, hypotension, somnolence, vomiting. Diovan dosage: 160 MG. During the same period patient was treated with NIFEDPINE. Patient recovered.Diovan Side Effects Report #6128974-1
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on Mar 19, 2009. Female patient, 68 years of age, was diagnosed with hypertension, blood glucose abnormal, blood glucose increased and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood glucose increased, blood pressure inadequately controlled, blood pressure increased, cardiac failure, dyspnoea. Diovan dosage: 80 MG, QD. During the same period patient was treated with METFORMIN HYDROCHLORIDE, DAONIL, INSULIN. Patient died on 01/10/2009.
Diovan Side Effects Report #6130269-7
Diovan side effect was reported by a Physician from GERMANY on Mar 18, 2009. Male patient, 68 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure fluctuation, blood pressure increased, disturbance in attention, dizziness
, hypertensive crisis, hypotension, somnolence, vomiting. Diovan dosage: 160 MG. During the same period patient was treated with NIFEDIPINE, BUDESONIDE. Patient recovered.Diovan Side Effects Report #4566560-5
Diovan side effect was reported by a Physician from on Jan 28, 2005. Male patient, 68 years of age, weighting 134.5 lb, was diagnosed with hypertension, atherosclerosis obliterans, hyperuricaemia and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, helicobacter infection, myocardial infarction, throat irritation, treatment noncompliance. Diovan dosage: 80 MG, QD. During the same period patient was treated with PLETAL, URINORM, URALYT. Patient died on 01/18/2005.
Diovan Side Effects Report #4737199-3
Diovan side effect was reported by a Physician from UNITED STATES on Aug 03, 2005. Female patient, 68 years of age, weighting 180.8 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, cerebral infarction, hemiparesis. Diovan dosage: 160 MG, QD. Patient was hospitalized and became disabled. Patient recovered.
Diovan Side Effects Report #4742951-4
Diovan side effect was reported by a Physician from UNITED STATES on Aug 03, 2005. Female patient, 68 years of age, weighting 180.8 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: arterial occlusive disease, blood pressure increased, cerebral infarction, dysarthria, hemiparesis. Diovan dosage: 160 MG, QD. Patient was hospitalized and became disabled. Patient recovered.
Diovan Side Effects Report #4792597-7
Diovan side effect was reported by a Physician from BRAZIL on Sept 29, 2005. Male patient, 68 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: back pain
, blood pressure increased, blood pressure systolic increased, diarrhoea, dyspnoea, insomnia, libido decreased, tachycardia. Diovan dosage: 80 MG. During the same period patient was treated with ENALAPRIL MALEATE. Patient recovered.Diovan Side Effects Report #4840072-3
Diovan side effect was reported by a Physician from UNITED STATES on Aug 03, 2005. Female patient, 68 years of age, weighting 180.0 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, carotid artery occlusion, cerebral infarction, dysarthria, hemiparesis, renal artery occlusion, stent placement. Diovan dosage: 160 MG, QD. Patient was hospitalized and became disabled. Patient recovered.
Diovan Side Effects Report #5031551-7
Diovan side effect was reported by a Physician from UNITED STATES on Apr 21, 2005. Male patient, 68 years of age, weighting 168.0 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased. Diovan dosage: unknown. During the same period patient was treated with DIOVAN HCT, CLONIDINE, ENALAPRIL MALEATE. Patient recovered.
Diovan Side Effects Report #5203374-7
Diovan side effect was reported by a Physician from BELGIUM on Jan 02, 2007. Male patient, 67 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: abdominal pain upper, arrhythmia
, blood pressure increased, cardiac failure, chromaturia, cough, depressed mood, dysgeusia, dyskinesia. Diovan dosage: unknown. During the same period patient was treated with ASCAL, QUINAPRIL. Patient was hospitalized. Patient recovered.Diovan Side Effects Report #5351984-9
Diovan side effect was reported by a Consumer or non-health professional from JAPAN on June 06, 2007. Female patient, 67 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood creatine phosphokinase increased, blood creatinine increased, blood lactate dehydrogenase increased, blood pressure decreased, blood pressure increased, blood urea increased. Diovan dosage: unknown. Patient died on 07/22/2006.
Diovan Side Effects Report #5073770-X
Diovan side effect was reported by a Physician from JAPAN on Aug 02, 2006. Female patient, 67 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood creatine phosphokinase increased, blood creatinine increased, blood lactate dehydrogenase increased, blood pressure decreased, blood pressure increased, blood urea increased. Diovan dosage: unknown. Patient died on 07/22/2006.
Diovan Side Effects Report #5099506-4
Diovan side effect was reported by a Physician from JAPAN on Aug 02, 2006. Female patient, 67 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood creatine phosphokinase increased, blood creatinine increased, blood lactate dehydrogenase increased, blood pressure decreased, blood pressure increased, blood urea increased. Diovan dosage: unknown. Patient died on 07/22/2006.
Diovan Side Effects Report #5121475-9
Diovan side effect was reported by a Physician from JAPAN on Aug 02, 2006. Female patient, 67 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood creatine phosphokinase increased, blood creatinine increased, blood lactate dehydrogenase increased, blood pressure decreased, blood pressure increased, blood urea increased. Diovan dosage: unknown. Patient died on 07/22/2006.
Diovan Side Effects Report #5144774-3
Diovan side effect was reported by a Health Professional from DENMARK on Oct 24, 2006. Female patient, 67 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure diastolic increased, blood pressure increased. Diovan dosage: 160MG/25MG. During the same period patient was treated with ATACAND ZID, CALCIUM CHANNEL BLOCKERS. Patient recovered.
Diovan Side Effects Report #5393295-1
Diovan side effect was reported by a Consumer or non-health professional from JAPAN on July 18, 2007. Female patient, 67 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood creatine phosphokinase increased, blood creatinine increased, blood lactate dehydrogenase increased, blood pressure decreased, blood pressure increased, blood urea increased. Diovan dosage: unknown. Patient died on 07/22/2006.
Diovan Side Effects Report #5416355-5
Diovan side effect was reported by a Consumer or non-health professional from ARGENTINA on Aug 09, 2007. Female patient, 67 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: back pain
, blood pressure increased, chest pain
. Diovan dosage: 160 MG, QD. During the same period patient was treated with INSULIN. Patient was hospitalized. Patient recovered.Diovan Side Effects Report #5699713-3
Diovan side effect was reported by a Consumer or non-health professional from on Mar 31, 2008. Female patient, 67 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, fatigue, heart rate decreased. Diovan dosage: 160 MG, QD. During the same period patient was treated with CRESTOR, NOVOHYDRAZIDE, METOPROLOL TARTRATE. Patient was hospitalized. Patient recovered.
Diovan Side Effects Report #5703758-4
Diovan side effect was reported by a Consumer or non-health professional from ARGENTINA on Apr 03, 2008. Female patient, 67 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: angioplasty
, blood pressure increased, hyperglycaemia. Diovan dosage: unknown. Patient recovered.Diovan Side Effects Report #6085685-9
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on Feb 17, 2009. Female patient, 67 years of age, weighting 185.0 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: anxiety
, blood pressure increased, euphoric mood, eye pain, fatigue, feeling cold, feeling hot, headache
, insomnia. Diovan dosage: unknown. Patient recovered.Diovan Side Effects Report #6130255-7
Diovan side effect was reported by a Consumer or non-health professional from BRAZIL on Mar 16, 2009. Female patient, 67 years of age, weighting 152.1 lb, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, cardiac disorder, face injury, fall
, feeling abnormal, head injury, heart rate increased, joint injury, malaise. Diovan dosage: unknown. During the same period patient was treated with AMLODIPINE BESYLATE, ATENOLOL. Patient recovered.Diovan Side Effects Report #4967484-1
Diovan side effect was reported by a Consumer or non-health professional from UNITED STATES on Mar 29, 2006. Female patient, 67 years of age, was diagnosed with hypertension, blood cholesterol increased and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, feeling cold, heart rate increased, tinnitus
. Diovan dosage: 160MG VAL/12.5MG HCT, QAM. During the same period patient was treated with LIPITOR. Patient recovered.Diovan Side Effects Report #5020955-4
Diovan side effect was reported by a Consumer or non-health professional from BELGIUM on May 31, 2006. Male patient, 67 years of age, was diagnosed with hypertension and was treated with Diovan. After drug was administered, patient experienced the following side effects: blood pressure increased, cardiac failure, cough, depressed mood, dyspnoea, extrasystoles, influenza like illness. Diovan dosage: unknown. During the same period patient was treated with ASCAL. Patient recovered.
Diovan and blood pressure increased 