Decitabine and disease progression Patient Reports February 12, 2012

Decitabine Side Effects Report #5568138-3
Decitabine side effect was reported by a Health Professional from UNITED STATES on Dec 04, 2007. Female patient, 64 years of age, weighting 110.5 lb, was diagnosed with ovarian cancer and was treated with Decitabine. After drug was administered, patient experienced the following side effects: constipation , disease progression, ovarian cancer, pain , pelvic abscess, small intestinal obstruction. Decitabine dosage: 10 MG, IN 1 DAY, INTRAVENOUS. During the same period patient was treated with TAMOXIFEN CITRATE, DOXIL, AMLODIPINE, ANAGRELIDE, NEXIUM, PROZAC, ATIVAN, METOPROLOL TARTRATE. Patient was hospitalized. Patient died on 11/23/2007.

Decitabine Side Effects Report #5533077-0
Decitabine side effect was reported by a Health Professional from UNITED STATES on Nov 30, 2007. Female patient, weighting 110.5 lb, was diagnosed with ovarian cancer and was treated with Decitabine. After drug was administered, patient experienced the following side effects: disease progression. Decitabine dosage: 10MG 1 HOUR X 5 DAYS IV. During the same period patient was treated with CARBOPLATIN, TAXOL, TAMOXIFEN CITRATE, DOXIL. Patient died on 11/23/2007.

Decitabine Side Effects Report #5486228-0
Decitabine side effect was reported by a Physician from UNITED STATES on Sept 27, 2007. Male patient, 75 years of age, weighting 208.5 lb, was diagnosed with myelodysplastic syndrome and was treated with Decitabine. After drug was administered, patient experienced the following side effects: anaemia, blood creatinine increased, blood pressure diastolic decreased, blood urea increased, cardiac failure congestive, disease progression, dizziness , faeces discoloured, fatigue. Decitabine dosage: 20 MG/M2, 1 IN 1 DAY, INTRAVENOUS. During the same period patient was treated with COREG, DIGOXIN, DIOVAN, ASPIRIN, PROTONIX, CILOSTAZOL, LIPITOR, PROCRIT. Patient was hospitalized. Patient recovered.

Decitabine Side Effects Report #5491283-8
Decitabine side effect was reported by a Physician from ISRAEL on Oct 08, 2007. Female patient, 73 years of age, weighting 136.7 lb, was diagnosed with myelodysplastic syndrome and was treated with Decitabine. After drug was administered, patient experienced the following side effects: abdominal pain upper, diarrhoea, disease progression, febrile neutropenia, lung infection, myelodysplastic syndrome, pneumonia , respiratory failure, sepsis . Decitabine dosage: INTRAVENOUS; 30 MG, INTRAVENOUS. Patient was hospitalized. Patient died on 09/25/2007.


Decitabine Side Effects Report #5745891-7
Decitabine side effect was reported by a Physician from CROATIA (local name: Hrvatska) on May 08, 2008. Male patient, 70 years of age, was diagnosed with myelodysplastic syndrome and was treated with Decitabine. After drug was administered, patient experienced the following side effects: blood creatinine increased, blood glucose increased, disease progression, haemoglobin decreased, hepatic failure, infection , multi-organ failure, sepsis , splenomegaly. Decitabine dosage: 15 MG/M2, 1 IN 8 HOUR, INTRAVENOUS. During the same period patient was treated with MEDROL. Patient was hospitalized. Patient died on 02/22/2006.

Decitabine Side Effects Report #5869314-2
Decitabine side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Aug 13, 2008. Female patient, 67 years of age, weighting 143.3 lb, was diagnosed with acute myeloid leukaemia and was treated with Decitabine. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, disease progression, neutropenia, phlebitis, pyrexia, thrombosis, vasculitis . Decitabine dosage: 31.2 MG, 1 IN 1 DAY, INTRAVENOUS; 31.8 MG, 1 IN 1 DAY, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Decitabine Side Effects Report #5663732-3
Decitabine side effect was reported by a Physician from UNITED STATES on Feb 25, 2008. Female patient, 65 years of age, was diagnosed with acute myeloid leukaemia, pneumonia fungal and was treated with Decitabine. After drug was administered, patient experienced the following side effects: abdominal hernia, abdominal pain , acute myeloid leukaemia recurrent, diabetes mellitus inadequate control, disease progression, febrile neutropenia, fluid overload, haematocrit decreased. Decitabine dosage: 20 MG/M2, IN 1 DAY, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Decitabine Side Effects Report #5507072-1
Decitabine side effect was reported by a Physician from UNITED STATES on Oct 22, 2007. Female patient, 18 years of age, was diagnosed with acute myeloid leukaemia and was treated with Decitabine. After drug was administered, patient experienced the following side effects: caecitis, cellulitis , disease progression, electrocardiogram t wave abnormal, febrile neutropenia, mouth injury, oral intake reduced, weight decreased, white blood cell count decreased. Decitabine dosage: 20 MG/M2, IN 1 DAY, INTRAVENOUS. During the same period patient was treated with VORINOSTAT. Patient was hospitalized. Patient recovered.

Decitabine Side Effects Report #5506432-2
Decitabine side effect was reported by a Physician from TURKEY on Oct 22, 2007. Female patient, 64 years of age, weighting 163.1 lb, was treated with Decitabine. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, blood fibrinogen abnormal, brain scan abnormal, caecitis, diarrhoea, disease progression, fibrin d dimer increased, haemoglobin decreased, haemorrhage intracranial. Decitabine dosage: 225 MG, INTRAVENOUS. Patient was hospitalized and became disabled. Patient died on 03/22/2007.


Decitabine Side Effects Report #5570043-3
Decitabine side effect was reported by a Physician from TURKEY on Dec 05, 2007. Female patient, 64 years of age, weighting 163.1 lb, was treated with Decitabine. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, aspiration tracheal abnormal, bacterial infection , blood fibrinogen decreased, caecitis, diarrhoea, disease progression, fibrin d dimer increased, haemoglobin decreased. Decitabine dosage: 225 MG, INTRAVENOUS. During the same period patient was treated with PIPERACILLIN TAZOBACTAM, AMIKACIN, PRIMAXIN, NETILMICIN. Patient was hospitalized and became disabled. Patient died on 03/22/2007.

Decitabine Side Effects Report #5657879-5
Decitabine side effect was reported by a Physician from TURKEY on Feb 22, 2008. Female patient, 64 years of age, weighting 163.1 lb, was treated with Decitabine. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, caecitis, disease progression, febrile neutropenia, fibrin d dimer increased, haemorrhage intracranial, liver function test abnormal, platelet count decreased, prothrombin time prolonged. Decitabine dosage: 225 MG, INTRAVENOUS. During the same period patient was treated with PIPERACILLIN TAZOBACTAM, AMIKACIN, PRIMAXIN, NETILMICIN SULPHATE, DEFEROXAMINE. Patient was hospitalized and became disabled. Patient died on 03/22/2007.

Decitabine Side Effects Report #5729578-2
Decitabine side effect was reported by a Physician from TURKEY on Apr 22, 2008. Female patient, 64 years of age, weighting 163.1 lb, was treated with Decitabine. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, caecitis, disease progression, febrile neutropenia, haemoglobin decreased, haemorrhage intracranial, hepatic function abnormal, multi-organ failure, platelet count decreased. Decitabine dosage: 225 MG, INTRAVENOUS. Patient was hospitalized and became disabled. Patient died on 03/22/2007.