Dasatinib and malignant neoplasm progression Patient Reports February 11, 2012

Dasatinib Side Effects Report #6024677-2
Dasatinib side effect was reported by a Consumer or non-health professional from UNITED STATES on Dec 29, 2008. Male patient, 51 years of age, weighting 134.5 lb, was diagnosed with sarcoma and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: abdominal distension, hypotension, malignant neoplasm progression, pyrexia, renal failure, urinary retention. Dasatinib dosage: unknown. Patient was hospitalized. Patient died on 12/24/2008.

Dasatinib Side Effects Report #5834140-7
Dasatinib side effect was reported by a Health Professional from UNITED STATES on July 30, 2008. Male patient, 49 years of age, weighting 220.5 lb, was diagnosed with sarcoma and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: abdominal pain

, brain oedema, cerebral haemorrhage, constipation

, dehydration, intestinal dilatation, leukocytosis, malignant neoplasm progression, metastases to central nervous system. Dasatinib dosage: 70MG BID FROM 08JUL08-23JUL08, DOSE REDUCED TO 50MG BID FROM 23JUL08-27JUL08. Patient was hospitalized. Patient recovered.

Dasatinib Side Effects Report #5706753-4
Dasatinib side effect was reported by a Health Professional from UNITED STATES on Apr 15, 2008. Male patient, weighting 135.1 lb, was diagnosed with sarcoma and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: constipation

, cough, dyspnoea, fatigue, malignant neoplasm progression, metastases to lung, musculoskeletal chest pain, oxygen saturation decreased, pleural effusion. Dasatinib dosage: 100 MG DAILY PO. During the same period patient was treated with ALBUTEROL, ATARAX, TENORMIN, TESSALON, LIPITOR, ZESTRIL, NEURONTIN, PREDNISONE. Patient was hospitalized. Patient recovered.

Dasatinib Side Effects Report #5735811-3
Dasatinib side effect was reported by a Health Professional from UNITED STATES on May 08, 2008. Male patient, weighting 123.5 lb, was diagnosed with sarcoma and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: atrial fibrillation

, bacterial infection

, bronchoscopy abnormal, constipation

, dyspnoea, fatigue, malignant neoplasm progression, malignant pleural effusion. Dasatinib dosage: 100 MG DAILY PO. During the same period patient was treated with ALBUTEROL, TENORMIN, LIPITOR, BENZONATATE, NEURONTIN, ATARAX, ZESTRIL, PREDNISONE. Patient was hospitalized. Patient died on 04/30/2008.

Dasatinib Side Effects Report #5827409-3
Dasatinib side effect was reported by a Health Professional from UNITED STATES on July 28, 2008. Male patient, 63 years of age, weighting 191.8 lb, was diagnosed with prostate cancer

and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: anorexia, dehydration, hyponatraemia, malignant neoplasm progression, overdose, pain

, vomiting. Dasatinib dosage: DASATINIB 50MG + 20 MG. During the same period patient was treated with ENTERIC ASPIRIN, DOCUSATE, PREDNISONE, METOPROLOL TARTRATE, ACETAMINOPHEN AND HYDROCODONE BITARTRATE, METFORMIN, PROCHLORPERAZINE, MORPHINE. Patient was hospitalized. Patient died on 07/24/2008.

Dasatinib Side Effects Report #6111651-0
Dasatinib side effect was reported by a Health Professional from UNITED STATES on Mar 04, 2009. Female patient, 57 years of age, weighting 108.0 lb, was diagnosed with non-small cell lung cancer and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: dyspnoea, malignant neoplasm progression, myocardial infarction, pneumonia

, refusal of treatment by relative, respiratory failure, upper respiratory tract infection. Dasatinib dosage: unknown. During the same period patient was treated with ERLOTINIB, ALBUTEROL, SPIRIVA, METOPROLOL TARTRATE. Patient was hospitalized. Patient died on 02/27/2009.

Dasatinib Side Effects Report #5099952-9
Dasatinib side effect was reported by a Health Professional from BELGIUM on May 18, 2006. Male patient, 75 years of age, was diagnosed with leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: enterococcal infection, malignant neoplasm progression, pleural effusion. Dasatinib dosage: unknown. Patient was hospitalized. Patient died on 06/04/2006.

Dasatinib Side Effects Report #5127765-8
Dasatinib side effect was reported by a Consumer or non-health professional from HUNGARY on May 12, 2006. Female patient, 69 years of age, was diagnosed with leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cardiac failure, malignant neoplasm progression, pericardial effusion. Dasatinib dosage: DOSING: 140 MG, 25JAN-09MAY, 180 MG STARTED 10MAY06 D/C: 15MAY06. During the same period patient was treated with FUROSEMIDE, IMATINIB MESILATE. Patient was hospitalized. Patient died on 05/26/2006.

Dasatinib Side Effects Report #5202448-4
Dasatinib side effect was reported by a Consumer or non-health professional from ITALY on Jan 04, 2007. Female patient, child 5 years of age, was diagnosed with leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: lower gastrointestinal haemorrhage, malignant neoplasm progression, upper gastrointestinal haemorrhage. Dasatinib dosage: unknown. During the same period patient was treated with PREDNISONE. Patient was hospitalized. Patient died on 01/03/2007.

Dasatinib Side Effects Report #5059486-4
Dasatinib side effect was reported by a Consumer or non-health professional from SOUTH AFRICA on July 12, 2006. Male patient, 40 years of age, was diagnosed with leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: balance disorder, cardio-respiratory arrest, cough, dizziness

, fall

, liver disorder, malignant neoplasm progression, pharyngolaryngeal pain. Dasatinib dosage: unknown. During the same period patient was treated with AMOXICILLIN, PHARMATON, ACETAMINOPHEN. Patient died on 07/10/2006.

Dasatinib Side Effects Report #5664973-1
Dasatinib side effect was reported by a Consumer or non-health professional from UNITED KINGDOM on Mar 13, 2008. Male patient, child 2 years of age, was diagnosed with leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: abdominal pain

, febrile neutropenia, hypocalcaemia, hypomagnesaemia, malignant neoplasm progression, musculoskeletal pain. Dasatinib dosage: unknown. During the same period patient was treated with AMBISOME, MEROPENEM, TEICOPLANIN, ACETAMINOPHEN, DIHYDROCODEINE, CHLORPHENIRAMINE MALEATE, COTRIM, ONDANSETRON. Patient was hospitalized. Patient recovered.

Dasatinib Side Effects Report #5469322-X
Dasatinib side effect was reported by a Health Professional from UNITED STATES on Sept 20, 2007. Female patient, 47 years of age, weighting 224.9 lb, was diagnosed with leiomyosarcoma and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: hyponatraemia, malignant neoplasm progression, pleural effusion. Dasatinib dosage: RESTARTED 16AUG-07,50MG BID,LAST DOSE WAS ON 05-SEP-07.. During the same period patient was treated with LASIX, POTASSIUM CHLORIDE, SYNTHROID, XANAX, COMPAZINE, TYLENOL, IMODIUM, CIPRO. Patient died on 09/19/2007.

Dasatinib Side Effects Report #5951675-7
Dasatinib side effect was reported by a Consumer or non-health professional from UNITED STATES on Nov 07, 2008. Male patient, 62 years of age, weighting 156.5 lb, was diagnosed with glioblastoma and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: asthenia, convulsion, dehydration, hypotension, lethargy, malignant neoplasm progression, pyrexia, rash

, renal failure acute. Dasatinib dosage: unknown. During the same period patient was treated with ERLOTINIB, COREG, LIPITOR, LISINOPRIL AND HYDROCHLOROTHIAZIDE, DONNATAL, DEPAKOTE, ZANTAC. Patient was hospitalized. Patient recovered.

Dasatinib Side Effects Report #5880162-X
Dasatinib side effect was reported by a Consumer or non-health professional from UNITED STATES on Sept 10, 2008. Male patient, weighting 185.8 lb, was diagnosed with glioblastoma and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: brain herniation, brain oedema, confusional state, malignant glioma, malignant neoplasm progression. Dasatinib dosage: 100MG DAYS 1-28 PO DAILY. During the same period patient was treated with ERLOTINIB GENENTECH, DILANTIN, KEPPRA, BENADRYL, LEVAQUIN, SENOKOT. Patient died on 05/27/2008.

Dasatinib Side Effects Report #5627983-6
Dasatinib side effect was reported by a Health Professional from UNITED STATES on Feb 12, 2008. Male patient, 68 years of age, was diagnosed with colorectal cancer metastatic and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: atelectasis, malignant neoplasm progression, nausea

, pleural effusion, pulmonary embolism

, small intestinal obstruction. Dasatinib dosage: unknown. During the same period patient was treated with CETUXIMAB, OXALIPLATIN, LEUCOVORIN CALCIUM, FLUOROURACIL, ASPIRIN, COMPAZINE, DARVON, EMEND. Patient was hospitalized. Patient recovered.

Dasatinib Side Effects Report #5530470-7
Dasatinib side effect was reported by a Health Professional from UNITED STATES on Nov 21, 2007. Female patient, 41 years of age, was diagnosed with colorectal cancer metastatic, insomnia, osteoporosis

, hypothyroidism and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cholecystitis, hepatitis

, hyperbilirubinaemia, malignant neoplasm progression. Dasatinib dosage: unknown. During the same period patient was treated with CETUXIMAB, OXALIPLATIN, LEUCOVORIN CALCIUM, FLUOROURACIL, AMBIEN, BONIVA, DEXAMETHASONE, LEVOTHYROXINE. Patient was hospitalized. Patient died on 11/14/2007.

Dasatinib Side Effects Report #5534144-8
Dasatinib side effect was reported by a Health Professional from UNITED STATES on Dec 03, 2007. Female patient, 41 years of age, was diagnosed with colorectal cancer metastatic, insomnia, osteoporosis

, hypothyroidism and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: aspartate aminotransferase increased, blood alkaline phosphatase increased, cholecystitis, hyperbilirubinaemia, malignant neoplasm progression. Dasatinib dosage: unknown. During the same period patient was treated with CETUXIMAB, OXALIPLATIN, LEUCOVORIN CALCIUM, FLUOROURACIL, AMBIEN, BONIVA, DEXAMETHASONE, LEVOTHYROXINE. Patient was hospitalized. Patient died on 11/14/2007.

Dasatinib Side Effects Report #5311128-6
Dasatinib side effect was reported by a Health Professional from PORTUGAL on Apr 26, 2007. Female patient, 76 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cardiac failure, cardio-respiratory arrest, lung infection, malignant neoplasm progression, pericardial effusion, pleural effusion, respiratory distress. Dasatinib dosage: unknown. During the same period patient was treated with INTERFERON, HYDROXYUREA, BUSULFAN. Patient died on 03/23/2007.

Dasatinib Side Effects Report #5242687-X
Dasatinib side effect was reported by a Consumer or non-health professional from FINLAND on Feb 13, 2007. Male patient, 70 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cardiac failure, chronic myeloid leukaemia, dyspnoea, malignant neoplasm progression. Dasatinib dosage: 70MG FROM 24-NOV-05 - 23-DEC-05; 0MG FROM 24-DEC-05 - 26-JAN-06; 40 MG FROM 23-JUN-06-05-NOV-06. Patient was hospitalized. Patient died on 11/14/2006.

Dasatinib Side Effects Report #5270084-X
Dasatinib side effect was reported by a Consumer or non-health professional from FINLAND on Mar 20, 2007. Male patient, 70 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cardiac failure, chronic myeloid leukaemia, dyspnoea, malignant neoplasm progression. Dasatinib dosage: 70MG FROM 24-NOV-05 - 23-DEC-05; 0MG FROM 24-DEC-05 - 26-JAN-06; 40 MG FROM 23-JUN-06-05-NOV-06. Patient was hospitalized. Patient died on 11/14/2006.

Dasatinib Side Effects Report #5272835-7
Dasatinib side effect was reported by a Consumer or non-health professional from FINLAND on Mar 21, 2007. Male patient, 70 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cardiac failure, chronic myeloid leukaemia, dyspnoea, malignant neoplasm progression. Dasatinib dosage: 70MG FROM 24-NOV-05 - 23-DEC-05; 0MG FROM 24-DEC-05 - 26-JAN-06; 40 MG FROM 23-JUN-06-05-NOV-06. Patient was hospitalized. Patient died on 11/14/2006.

Dasatinib Side Effects Report #5164549-9
Dasatinib side effect was reported by a Consumer or non-health professional from FINLAND on Nov 28, 2006. Male patient, 70 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cardiac failure, chronic myeloid leukaemia, dyspnoea, malignant neoplasm progression. Dasatinib dosage: unknown. Patient was hospitalized. Patient died on 11/14/2006.

Dasatinib Side Effects Report #5661837-4
Dasatinib side effect was reported by a Consumer or non-health professional from SWEDEN on Mar 05, 2008. Male patient, 59 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: blast cell count increased, dyspnoea, malignant neoplasm progression, pleural effusion. Dasatinib dosage: 140MG 08JUN TO 08JUL-05; 200MG 08JUL05 TO 17JAN06, 27JAN TO 15FEB06; 140MG 18FEB TO 28FEB06. During the same period patient was treated with DARBEPOETIN ALFA, TRAMADOL, CYANOCOBALAMIN, ALLOPURINOL, ACETAMINOPHEN, LOPERAMIDE, FLUCONAZOLE, FUROSEMIDE. Patient was hospitalized. Patient died on 05/26/2006.

Dasatinib Side Effects Report #5118481-7
Dasatinib side effect was reported by a Health Professional from FRANCE on Feb 15, 2006. Female patient, 54 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cardiac failure, cardiogenic shock, chest pain

, coma, malignant neoplasm progression, pleural effusion, respiratory failure, tumour lysis syndrome. Dasatinib dosage: unknown. During the same period patient was treated with CLAVENTIN, AMIKLIN, VANCOMYCIN, LEVOFLOXACIN, SKENAN. Patient died on 02/17/2006.

Dasatinib Side Effects Report #5949882-2
Dasatinib side effect was reported by a Physician from SPAIN on Nov 03, 2008. Female patient, 54 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: gene mutation, malignant neoplasm progression, neutropenia, thrombocytopenia. Dasatinib dosage: unknown. Patient recovered.

Dasatinib Side Effects Report #5994134-8
Dasatinib side effect was reported by a Health Professional from SINGAPORE on Dec 08, 2008. Male patient, 48 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: circulatory collapse, malignant neoplasm progression. Dasatinib dosage: 140 MG; JUN-2008 DECREASED TO 100 MG. During the same period patient was treated with FUROSEMIDE, DEXAMETHASONE. Patient died on 11/15/2008.

Dasatinib Side Effects Report #6107576-7
Dasatinib side effect was reported by a Health Professional from SINGAPORE on Mar 04, 2009. Male patient, 48 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: circulatory collapse, malignant neoplasm progression. Dasatinib dosage: 140 MG; JUN-2008 DECREASED TO 100 MG. During the same period patient was treated with FUROSEMIDE, DEXAMETHASONE. Patient died on 11/15/2008.

Dasatinib Side Effects Report #5095795-0
Dasatinib side effect was reported by a Health Professional from POLAND on Aug 14, 2006. Male patient, 44 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cerebral haemorrhage, cerebral ischaemia, chronic myeloid leukaemia, malignant neoplasm progression, thrombocytopenia. Dasatinib dosage: 140MG 20DEC TO 14AUG06 180MG 15AUG TO 18AUG06. During the same period patient was treated with HUMULIN M. Patient was hospitalized. Patient died.

Dasatinib Side Effects Report #5063559-X
Dasatinib side effect was reported by a Health Professional from UNITED STATES on May 23, 2006. Male patient, 39 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: chronic myeloid leukaemia, duodenal ulcer, dyspnoea, gastrointestinal ulcer, malignant neoplasm progression, nausea

, pleural effusion, respiratory distress, respiratory failure. Dasatinib dosage: unknown. Patient was hospitalized. Patient died on 07/09/2006.

Dasatinib Side Effects Report #5948371-9
Dasatinib side effect was reported by a Health Professional from UNITED STATES on Nov 10, 2008. Female patient, weighting 150.1 lb, was diagnosed with breast cancer stage iv and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cough, dyspnoea, dyspnoea exertional, malignant neoplasm progression, pleural effusion, pneumonitis. Dasatinib dosage: 70 MG BID PO. During the same period patient was treated with MS CONTIN, VOLTAREN, DICLOFENAC, VICODIN, AMITRIPTYLINE, ACETAMINOPHEN, LASIX. Patient recovered.

Dasatinib Side Effects Report #5100052-X
Dasatinib side effect was reported by a Health Professional from BELGIUM on Sept 04, 2006. Female patient, 21 years of age, weighting 132.3 lb, was diagnosed with acute myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: bronchopulmonary aspergillosis, cardiac failure, endocarditis

, malignant neoplasm progression, myocardial infarction, respiratory distress. Dasatinib dosage: unknown. During the same period patient was treated with CASPOFUNGIN ACETATE, CEFEPIME, VANCOMYCIN, AMIKACIN, AMPHOTERICIN B, VORICONAZOLE, RANITIDINE, ACYCLOVIR. Patient died on 07/20/2006.

Dasatinib Side Effects Report #5102412-X
Dasatinib side effect was reported by a Health Professional from BELGIUM on Sept 04, 2006. Female patient, 21 years of age, weighting 132.3 lb, was diagnosed with acute myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: bronchopulmonary aspergillosis, cardiac failure, endocarditis

, malignant neoplasm progression, myocardial infarction, respiratory distress. Dasatinib dosage: unknown. During the same period patient was treated with CASPOFUNGIN ACETATE, CEFEPIME, VANCOMYCIN, AMIKACIN, AMPHOTERICIN B, VORICONAZOLE, RANITIDINE, ACYCLOVIR. Patient died on 07/20/2006.

Dasatinib Side Effects Report #5105756-0
Dasatinib side effect was reported by a Health Professional from BELGIUM on Sept 04, 2006. Female patient, 21 years of age, weighting 132.3 lb, was diagnosed with acute myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, bronchopulmonary aspergillosis, cardiac failure, endocarditis

, malignant neoplasm progression, myocardial infarction. Dasatinib dosage: unknown. During the same period patient was treated with CASPOFUNGIN ACETATE, CEFEPIME, VANCOMYCIN, AMIKACIN, AMPHOTERICIN B, VORICONAZOLE, RANITIDINE, ACYCLOVIR. Patient died on 07/20/2006.

Dasatinib Side Effects Report #5103787-8
Dasatinib side effect was reported by a Consumer or non-health professional from UNITED STATES on Sept 08, 2006. Female patient, child 8 years of age, weighting 68.34 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: hypokalaemia, malignant neoplasm progression. Dasatinib dosage: unknown. Patient recovered.

Dasatinib Side Effects Report #5108198-7
Dasatinib side effect was reported by a Consumer or non-health professional from UNITED STATES on Sept 08, 2006. Female patient, child 8 years of age, weighting 68.34 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: hypokalaemia, malignant neoplasm progression. Dasatinib dosage: unknown. During the same period patient was treated with PIPERACILLIN AND TAZOBACTAM, AMITRIPTYLINE, CIPROFLOXACIN, DEXAMETHASONE, DIMENHYDRINATE, METOCLOPRAMIDE, PENICILLIN V POTASSIUM, SEPTRA. Patient recovered.

Dasatinib Side Effects Report #5248111-5
Dasatinib side effect was reported by a Consumer or non-health professional from SPAIN on Feb 19, 2007. Male patient, child 10 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: bronchopulmonary aspergillosis, malignant neoplasm progression, mucosal inflammation, pancytopenia. Dasatinib dosage: unknown. Patient died.

Dasatinib Side Effects Report #5243864-4
Dasatinib side effect was reported by a Health Professional from ITALY on Feb 14, 2007. Male patient, 76 years of age, was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cardiac arrest

, cardiac failure acute, malignant neoplasm progression, pleural effusion. Dasatinib dosage: unknown. During the same period patient was treated with HYDROXYUREA, DILATREND, LANOXIN, LASIX, NITRO, ASPIRIN. Patient died on 01/27/2007.

Dasatinib and malignant neoplasm progression

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Dasatinib and malignant neoplasm progression Patient Reports February 11, 2012

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