Dasatinib and cardiac failure Patient Reports February 11, 2012

Dasatinib Side Effects Report #5127765-8
Dasatinib side effect was reported by a Consumer or non-health professional from HUNGARY on May 12, 2006. Female patient, 69 years of age, was diagnosed with leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cardiac failure, malignant neoplasm progression, pericardial effusion. Dasatinib dosage: DOSING: 140 MG, 25JAN-09MAY, 180 MG STARTED 10MAY06 D/C: 15MAY06. During the same period patient was treated with FUROSEMIDE, IMATINIB MESILATE. Patient was hospitalized. Patient died on 05/26/2006.

Dasatinib Side Effects Report #5311128-6
Dasatinib side effect was reported by a Health Professional from PORTUGAL on Apr 26, 2007. Female patient, 76 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cardiac failure, cardio-respiratory arrest, lung infection, malignant neoplasm progression, pericardial effusion, pleural effusion, respiratory distress. Dasatinib dosage: unknown. During the same period patient was treated with INTERFERON, HYDROXYUREA, BUSULFAN. Patient died on 03/23/2007.

Dasatinib Side Effects Report #5242687-X
Dasatinib side effect was reported by a Consumer or non-health professional from FINLAND on Feb 13, 2007. Male patient, 70 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cardiac failure, chronic myeloid leukaemia, dyspnoea, malignant neoplasm progression. Dasatinib dosage: 70MG FROM 24-NOV-05 - 23-DEC-05; 0MG FROM 24-DEC-05 - 26-JAN-06; 40 MG FROM 23-JUN-06-05-NOV-06. Patient was hospitalized. Patient died on 11/14/2006.

Dasatinib Side Effects Report #5270084-X
Dasatinib side effect was reported by a Consumer or non-health professional from FINLAND on Mar 20, 2007. Male patient, 70 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cardiac failure, chronic myeloid leukaemia, dyspnoea, malignant neoplasm progression. Dasatinib dosage: 70MG FROM 24-NOV-05 - 23-DEC-05; 0MG FROM 24-DEC-05 - 26-JAN-06; 40 MG FROM 23-JUN-06-05-NOV-06. Patient was hospitalized. Patient died on 11/14/2006.


Dasatinib Side Effects Report #5272835-7
Dasatinib side effect was reported by a Consumer or non-health professional from FINLAND on Mar 21, 2007. Male patient, 70 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cardiac failure, chronic myeloid leukaemia, dyspnoea, malignant neoplasm progression. Dasatinib dosage: 70MG FROM 24-NOV-05 - 23-DEC-05; 0MG FROM 24-DEC-05 - 26-JAN-06; 40 MG FROM 23-JUN-06-05-NOV-06. Patient was hospitalized. Patient died on 11/14/2006.

Dasatinib Side Effects Report #5164549-9
Dasatinib side effect was reported by a Consumer or non-health professional from FINLAND on Nov 28, 2006. Male patient, 70 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cardiac failure, chronic myeloid leukaemia, dyspnoea, malignant neoplasm progression. Dasatinib dosage: unknown. Patient was hospitalized. Patient died on 11/14/2006.

Dasatinib Side Effects Report #5105666-9
Dasatinib side effect was reported by a Health Professional from FRANCE on Feb 15, 2006. Female patient, 54 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: blood lactate dehydrogenase increased, bronchitis , cardiac failure, cardiogenic shock, chest pain , coma, lung disorder, malignant neoplasm progression. Dasatinib dosage: unknown. During the same period patient was treated with CLAVENTIN, AMIKLIN, VANCOMYCIN, TAVANIC, SKENAN. Patient died on 02/17/2006.

Dasatinib Side Effects Report #5118481-7
Dasatinib side effect was reported by a Health Professional from FRANCE on Feb 15, 2006. Female patient, 54 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cardiac failure, cardiogenic shock, chest pain , coma, malignant neoplasm progression, pleural effusion, respiratory failure, tumour lysis syndrome. Dasatinib dosage: unknown. During the same period patient was treated with CLAVENTIN, AMIKLIN, VANCOMYCIN, TAVANIC, SKENAN. Patient died on 02/17/2006.

Dasatinib Side Effects Report #5135368-4
Dasatinib side effect was reported by a Health Professional from FRANCE on Feb 15, 2006. Female patient, 54 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cardiac failure, cardiogenic shock, chest pain , coma, malignant neoplasm progression, pleural effusion, respiratory failure, tumour lysis syndrome. Dasatinib dosage: unknown. During the same period patient was treated with CLAVENTIN, AMIKLIN, VANCOMYCIN, LEVOFLOXACIN, SKENAN. Patient died on 02/17/2006.


Dasatinib Side Effects Report #5146561-9
Dasatinib side effect was reported by a Health Professional from FRANCE on Feb 15, 2006. Female patient, 54 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cardiac failure, cardiogenic shock, chest pain , coma, malignant neoplasm progression, pleural effusion, respiratory failure, tumour lysis syndrome. Dasatinib dosage: unknown. During the same period patient was treated with CLAVENTIN, AMIKLIN, VANCOMYCIN, LEVOFLOXACIN, SKENAN. Patient died on 02/17/2006.

Dasatinib Side Effects Report #5150895-1
Dasatinib side effect was reported by a Health Professional from FRANCE on Feb 15, 2006. Female patient, 54 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: cardiac failure, cardiogenic shock, chest pain , coma, malignant neoplasm progression, pleural effusion, respiratory failure, tumour lysis syndrome. Dasatinib dosage: unknown. During the same period patient was treated with CLAVENTIN, AMIKLIN, VANCOMYCIN, LEVOFLOXACIN, SKENAN. Patient died on 02/17/2006.

Dasatinib Side Effects Report #5100052-X
Dasatinib side effect was reported by a Health Professional from BELGIUM on Sept 04, 2006. Female patient, 21 years of age, weighting 132.3 lb, was diagnosed with acute myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: bronchopulmonary aspergillosis, cardiac failure, endocarditis , malignant neoplasm progression, myocardial infarction, respiratory distress. Dasatinib dosage: unknown. During the same period patient was treated with CASPOFUNGIN ACETATE, CEFEPIME, VANCOMYCIN, AMIKACIN, AMPHOTERICIN B, VORICONAZOLE, RANITIDINE, ACYCLOVIR. Patient died on 07/20/2006.

Dasatinib Side Effects Report #5102412-X
Dasatinib side effect was reported by a Health Professional from BELGIUM on Sept 04, 2006. Female patient, 21 years of age, weighting 132.3 lb, was diagnosed with acute myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: bronchopulmonary aspergillosis, cardiac failure, endocarditis , malignant neoplasm progression, myocardial infarction, respiratory distress. Dasatinib dosage: unknown. During the same period patient was treated with CASPOFUNGIN ACETATE, CEFEPIME, VANCOMYCIN, AMIKACIN, AMPHOTERICIN B, VORICONAZOLE, RANITIDINE, ACYCLOVIR. Patient died on 07/20/2006.

Dasatinib Side Effects Report #5105756-0
Dasatinib side effect was reported by a Health Professional from BELGIUM on Sept 04, 2006. Female patient, 21 years of age, weighting 132.3 lb, was diagnosed with acute myeloid leukaemia and was treated with Dasatinib. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, bronchopulmonary aspergillosis, cardiac failure, endocarditis , malignant neoplasm progression, myocardial infarction. Dasatinib dosage: unknown. During the same period patient was treated with CASPOFUNGIN ACETATE, CEFEPIME, VANCOMYCIN, AMIKACIN, AMPHOTERICIN B, VORICONAZOLE, RANITIDINE, ACYCLOVIR. Patient died on 07/20/2006.