Clofarabine and sepsis Patient Reports February 11, 2012

Clofarabine Side Effects Report #5897833-1
Clofarabine side effect was reported by a Health Professional from UNITED STATES on Sept 24, 2008. Female patient, weighting 132.3 lb, was diagnosed with non-hodgkin's lymphoma and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: asthenia, confusional state, pyrexia, renal failure acute, respiratory disorder, sepsis . Clofarabine dosage: 40MG/M2 DAILY IV DRIP. During the same period patient was treated with MELPHALAN, CAMPATH. Patient recovered.

Clofarabine Side Effects Report #5192273-5
Clofarabine side effect was reported by a Health Professional from UNITED STATES on Dec 18, 2006. Male patient, 70 years of age, was diagnosed with myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, blood culture positive, face injury, fall , febrile neutropenia, hypotension, laceration, sepsis , staphylococcal infection . Clofarabine dosage: 80 MG QD X 5 IV. During the same period patient was treated with CYTARABINE, LEVAQUIN, ACYCLOVIR, VERSED. Patient was hospitalized. Patient died on 11/07/2006.

Clofarabine Side Effects Report #5512604-3
Clofarabine side effect was reported by a Health Professional from UNITED KINGDOM on Oct 24, 2007. Female patient, 69 years of age, was diagnosed with myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: coma, electrolyte imbalance, hepatorenal failure, hypokalaemia, sepsis . Clofarabine dosage: unknown. During the same period patient was treated with DAUNORUBICIN, GETUZUMAB OZOGAMICIN. Patient died on 10/16/2007.

Clofarabine Side Effects Report #5077754-7
Clofarabine side effect was reported by a Physician from UNITED STATES on July 25, 2006. Male patient, 68 years of age, was diagnosed with myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: multi-organ failure, pancreatitis, sepsis . Clofarabine dosage: 40 MG/M2 QD X 5 IV. During the same period patient was treated with CYTARABINE. Patient was hospitalized. Patient died.


Clofarabine Side Effects Report #5077752-3
Clofarabine side effect was reported by a Physician from UNITED STATES on July 25, 2006. Female patient was diagnosed with myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: sepsis , stevens-johnson syndrome. Clofarabine dosage: 40 MG/M2 QD X 5 IV. During the same period patient was treated with CYTARABINE. Patient was hospitalized. Patient died.

Clofarabine Side Effects Report #5077755-9
Clofarabine side effect was reported by a Physician from UNITED STATES on July 25, 2006. Female patient was diagnosed with myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: multi-organ failure, sepsis . Clofarabine dosage: 40 MG/M2 QD X 5 IV. During the same period patient was treated with CYTARABINE. Patient was hospitalized. Patient died.

Clofarabine Side Effects Report #5077757-2
Clofarabine side effect was reported by a Physician from UNITED STATES on July 25, 2006. Female patient was diagnosed with myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: sepsis . Clofarabine dosage: 40 MG/M2 QD X 5 IV. During the same period patient was treated with CYTARABINE. Patient was hospitalized. Patient died.

Clofarabine Side Effects Report #4935081-X
Clofarabine side effect was reported by a Health Professional from UNITED STATES on Mar 03, 2006. Male patient, weighting 187.6 lb, was diagnosed with amyotrophic lateral sclerosis  and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: bacteraemia, hypotension, pyrexia, sepsis . Clofarabine dosage: 47.7 MG X 4 DAYS IV. During the same period patient was treated with ACYCLOVIR, NEXIUM, ISOSORBIDE, FLOMAX, LESCOL, SPIRIVA, ADVAIR DISKUS. Patient was hospitalized. Patient recovered.

Clofarabine Side Effects Report #5869466-4
Clofarabine side effect was reported by a Consumer or non-health professional from UNITED KINGDOM on July 18, 2008. Female patient, 79 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: confusional state, dehydration, diarrhoea, fall , haemorrhage intracranial, hypotension, lethargy, sepsis , thrombocytopenia. Clofarabine dosage: 40 MG, QDX5, INTRAVENOUS. During the same period patient was treated with METOCLOPRAMIDE, ALLOPURINOL, HYPROMELLOSE, ACYCLOVIR, SULFAMETHOXAZOLE AND TRIMETHOPRIM, PEPTAC, ONDANZETRON, OMEPRAZOLE. Patient died on 03/01/2005.


Clofarabine Side Effects Report #5869466-4
Clofarabine side effect was reported by a Physician from UNITED KINGDOM on July 18, 2008. Female patient, 79 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: confusional state, dehydration, diarrhoea, fall , haemorrhage intracranial, hypotension, lethargy, sepsis , thrombocytopenia. Clofarabine dosage: 40 MG, QDX5, INTRAVENOUS. During the same period patient was treated with METOCLOPRAMIDE, ALLOPURINOL, HYDROMELLOSE, ACYCLOVIR, SULFAMETHOXAZOLE AND TRIMETHOPRIM, PEPTAC, ONDANSETRON, OMEPRAZOLE. Patient died on 03/01/2005.

Clofarabine Side Effects Report #5850982-6
Clofarabine side effect was reported by a Consumer or non-health professional from IRELAND on July 28, 2008. Female patient, 75 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: haemodialysis, hypoalbuminaemia, malaise, pleural effusion, renal failure acute, sepsis . Clofarabine dosage: 52 MG, QDX5, INTRAVENOUS. During the same period patient was treated with FUROSEMIDE, PIPERACILLIN AND TAZOBACTAM, GENTAMICIN, LEVOTHYROXINE. Patient recovered.

Clofarabine Side Effects Report #4883848-9
Clofarabine side effect was reported by a Consumer or non-health professional from IRELAND on Dec 29, 2005. Female patient, 75 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: atrial fibrillation , haemodialysis, malaise, neutropenic sepsis, pleural effusion, renal failure acute, respiratory disorder. Clofarabine dosage: 52 MG QD X 5 IV. During the same period patient was treated with FUROSEMIDE, TAZOCIN, GENTAMICIN, ELTROXIN. Patient recovered.

Clofarabine Side Effects Report #4669713-0
Clofarabine side effect was reported by a Consumer or non-health professional from on Apr 25, 2005. Male patient, 74 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: collapse of lung, erythema, hypotension, infection , renal failure acute, respiratory failure, sepsis , systemic inflammatory response syndrome. Clofarabine dosage: 26 MG QD X 5 IV. During the same period patient was treated with CYCLIZINE, ACYCLOVIR, LANSOPRAZOLE, ALLOPURINOL. Patient died on 04/27/2005.

Clofarabine Side Effects Report #4844905-6
Clofarabine side effect was reported by a Physician from UNITED STATES on Nov 11, 2005. Male patient, 73 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: cardio-respiratory arrest, multi-organ failure, renal failure acute, sepsis . Clofarabine dosage: 49.2 MG QD X 5 IV. During the same period patient was treated with CYTARABINE, CEFEPIME, ACYCLOVIR, NOREPINEPHRINE, AMIODARONE, TYLENOL, BENADRYL. Patient died on 06/30/2005.


Clofarabine Side Effects Report #4674882-2
Clofarabine side effect was reported by a Physician from on May 12, 2005. Male patient, 72 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: anuria, disorientation, haemodialysis, hypotension, neutropenia, renal failure acute, sepsis , somnolence. Clofarabine dosage: 52.8 MG QD X 5 IV. During the same period patient was treated with CIPROFLOXACIN, ITRACONAZOLE, ACYCLOVIR, ALLOPURINOL, ONDANSETRON, TRAMADOL, MEROPENEM. Patient died on 05/04/2005.

Clofarabine Side Effects Report #5162254-6
Clofarabine side effect was reported by a Physician from UNITED STATES on Nov 17, 2006. Male patient, 70 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: fall , febrile neutropenia, hypotension, sepsis , skin laceration, staphylococcal infection , syncope. Clofarabine dosage: 80 MG QD X 5 IV. During the same period patient was treated with VANCOMYCIN, FORTAZ, LEVAQUIN, CANCIDAS, ZOSYN, ACYCLOVIR, AMIODARONE, VERSED. Patient was hospitalized. Patient died on 11/07/2006.

Clofarabine Side Effects Report #4658061-0
Clofarabine side effect was reported by a Health Professional from on May 03, 2005. Male patient, 68 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: neutropenia, renal failure acute, sepsis . Clofarabine dosage: 54.9 MG QD X 5 IV. During the same period patient was treated with ALLOPURINOL, TAZOCIN, GENTAMICIN, TEICOPLANIN, ALBECET, MEROPENEM, FILGRASTIM. Patient was hospitalized. Patient died on 05/03/2005.

Clofarabine Side Effects Report #4659272-0
Clofarabine side effect was reported by a Health Professional from on May 03, 2005. Male patient, 68 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: myocardial ischaemia, neutropenia, renal failure acute, sepsis . Clofarabine dosage: 54.9 MG QD X 5 IV. During the same period patient was treated with ALLOPURINOL, TAZOCIN, GENTAMICIN, TEICOPLANIN, ALBECET, MEROPENEM, FILGRASTIM. Patient was hospitalized. Patient died on 05/03/2005.

Clofarabine Side Effects Report #5211326-6
Clofarabine side effect was reported by a Health Professional from UNITED STATES on Jan 04, 2007. Male patient, 67 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: hypotension, no therapeutic response, sepsis . Clofarabine dosage: 84 MG DAILY IV. During the same period patient was treated with CYTARABINE. Patient died on 01/04/2007.


Clofarabine Side Effects Report #5077761-4
Clofarabine side effect was reported by a Physician from UNITED STATES on July 26, 2006. Male patient, 67 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, febrile neutropenia, pancytopenia, pneumonia , renal failure, sepsis . Clofarabine dosage: 87.2 MG DAILY IV. During the same period patient was treated with CYTARABINE, FLAGYL I, INSULIN, ATENOLOL, ALLOPURINOL, FAMVIR, ALTACE, LASIX. Patient died on 07/24/2006.

Clofarabine Side Effects Report #5077763-8
Clofarabine side effect was reported by a Physician from UNITED STATES on July 25, 2006. Female patient, 67 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: neutropenia, sepsis . Clofarabine dosage: 40 MG/M2 QD X 5 IV. During the same period patient was treated with CYTARABINE. Patient was hospitalized. Patient died.

Clofarabine Side Effects Report #4945352-9
Clofarabine side effect was reported by a Health Professional from UNITED STATES on Mar 15, 2006. Male patient, 67 years of age, weighting 187.6 lb, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: hypotension, sepsis . Clofarabine dosage: 47.7 MG X4 DAYS IV. During the same period patient was treated with AMOXICILLIN, MAGNESIUM SULPHATE, ROSIGLITAZONE, METFORMIN, IMIPENEM, ACETAMINOPHEN, DEXTROSE, GLUCAGON. Patient was hospitalized. Patient recovered.

Clofarabine Side Effects Report #4949722-4
Clofarabine side effect was reported by a Physician from UNITED STATES on Mar 03, 2006. Male patient, 66 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: infection , nephropathy toxic, sepsis . Clofarabine dosage: 30 MG/M2 QD IV. During the same period patient was treated with CYTARABINE. Patient died.

Clofarabine Side Effects Report #5509079-7
Clofarabine side effect was reported by a Physician from UNITED STATES on July 03, 2007. Male patient, 63 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: blood bilirubin increased, periorbital haematoma, pneumonia , renal failure acute, respiratory failure, sepsis , traumatic intracranial haemorrhage. Clofarabine dosage: 47 MG QD X 5 IV. During the same period patient was treated with IDARUBICIN, CYTARABINE, PREDTE, XOPENEX, ATROVENT, ZOSYN, TIGECYCLINE. Patient was hospitalized. Patient died on 07/19/2007.


Clofarabine Side Effects Report #5115004-3
Clofarabine side effect was reported by a Physician from UNITED STATES on Sept 08, 2006. Male patient, 15 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: cardiac arrest , condition aggravated, hypotension, neutropenia, sepsis . Clofarabine dosage: 52 MG/M2 QD X 5 IV. Patient died on 09/06/2006.

Clofarabine Side Effects Report #5519211-7
Clofarabine side effect was reported by a Health Professional from UNITED STATES on Nov 14, 2007. Male patient, weighting 97.00 lb, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: acidosis, blood culture positive, bradycardia, cardiac arrest , pseudomonas infection, renal impairment, sepsis , sputum culture positive, stenotrophomonas infection. Clofarabine dosage: 60MG DAILY TIMES 5 IV. During the same period patient was treated with MELPHALAN, CAMPATH. Patient died on 11/12/2007.

Clofarabine Side Effects Report #5528506-2
Clofarabine side effect was reported by a Health Professional from UNITED KINGDOM on Nov 05, 2007. Male patient was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: catheter related infection, fluid intake reduced, nausea , oedema, palmar-plantar erythrodysaesthesia syndrome, renal impairment, sepsis , therapeutic agent toxicity. Clofarabine dosage: 20 MG/M2 QD X 5 IV. During the same period patient was treated with DAUNORUBICIN. Patient died.

Clofarabine Side Effects Report #4998183-8
Clofarabine side effect was reported by a Health Professional from UNITED STATES on Apr 24, 2006. Female patient was diagnosed with acute myeloid leukaemia, myelodysplastic syndrome and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: sepsis . Clofarabine dosage: 40 MG/M2 DAILY IV. During the same period patient was treated with CYTARABINE. Patient died.

Clofarabine Side Effects Report #5101926-6
Clofarabine side effect was reported by a Physician from UNITED STATES on Aug 25, 2006. Male patient, 60 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: hypotension, klebsiella infection, neutropenia, sepsis . Clofarabine dosage: 58 MG QD X 3 IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, BACTRIM, DIFLUCAN, MYCOSTATIN, VALCYTE, NEXIUM, MEGACE. Patient was hospitalized. Patient recovered.


Clofarabine Side Effects Report #4905634-3
Clofarabine side effect was reported by a Pharmacist from UNITED STATES on Feb 03, 2006. Male patient, 37 years of age, weighting 198.4 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: liver function test abnormal, palmar-plantar erythrodysaesthesia syndrome, sepsis , skin exfoliation. Clofarabine dosage: 80 MG QD X 5 IV. During the same period patient was treated with CYTARABINE, VORICONAZOLE, ZOSYN, INSULIN. Patient died.

Clofarabine Side Effects Report #4915924-6
Clofarabine side effect was reported by a Pharmacist from UNITED STATES on Dec 25, 2005. Male patient, 37 years of age, weighting 198.4 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: liver function test abnormal, palmar-plantar erythrodysaesthesia syndrome, sepsis , skin exfoliation, zinc deficiency. Clofarabine dosage: 80 MG QD X 5 IV. During the same period patient was treated with CYTARABINE, VORICONAZOLE, ZOSYN, INSULIN. Patient died.

Clofarabine Side Effects Report #5291451-4
Clofarabine side effect was reported by a Physician from UNITED STATES on Mar 22, 2007. Female patient, 24 years of age, weighting 223.5 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: acinetobacter bacteraemia, acute respiratory distress syndrome, haemorrhage, pleural effusion, pulmonary oedema, sepsis , serratia sepsis. Clofarabine dosage: 82.8 MG DAILY IV. During the same period patient was treated with CYTARABINE. Patient was hospitalized. Patient died on 03/26/2007.

Clofarabine Side Effects Report #5878619-0
Clofarabine side effect was reported by a Physician from UNITED KINGDOM on Sept 03, 2008. Male patient, 75 years of age, was diagnosed with acute leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: diabetes mellitus, renal failure, sepsis , tumour lysis syndrome. Clofarabine dosage: unknown. Patient was hospitalized. Patient died on 05/22/2008.

Clofarabine Side Effects Report #5105824-3
Clofarabine side effect was reported by a Health Professional from UNITED STATES on Sept 06, 2006. Female patient, 59 years of age, weighting 143.3 lb, was diagnosed with acute leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: enterococcal bacteraemia, haemodialysis, hypotension, renal disorder, renal failure, sepsis . Clofarabine dosage: 17 MG DAILY. During the same period patient was treated with CYCLOPHOSPHAMIDE, ACETAMINOPHEN, ALLOPURINOL, HYDROCORTISONE. Patient was hospitalized. Patient died on 09/02/2006.