Busulfex and sepsis Patient Reports February 13, 2012

Busulfex Side Effects Report #5871281-2
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Aug 19, 2008. Male patient, child 7 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, bone marrow transplant , cystitis haemorrhagic, diarrhoea, malaise, nausea , sepsis , stomatitis. Busulfex dosage: 68 ML INTRAVENOUS. During the same period patient was treated with CYCLOPHOSPHAMIDE, VALPROATE, LENOGRASTIM, CYCLOSPORINE. Patient was hospitalized. Patient recovered.

Busulfex Side Effects Report #5698228-6
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Mar 21, 2008. Male patient, 58 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: disease recurrence, myelodysplastic syndrome, sepsis . Busulfex dosage: unknown. Patient died on 06/22/2007.

Busulfex Side Effects Report #5729836-1
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Apr 21, 2008. Male patient, 58 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , cerebral haemorrhage, diarrhoea, malaise, multi-organ failure, pneumonia , sepsis , shock. Busulfex dosage: 33.2 ML INTRAVENOUS; 16.6 ML INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, MELPHALAN, VALPROATE, METHOTREXATE. Patient was hospitalized. Patient died.

Busulfex Side Effects Report #5743637-X
Busulfex side effect was reported by a Health Professional from JAPAN on May 08, 2008. Female patient, 57 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, alanine aminotransferase increased, anorexia, blood bilirubin increased, bone marrow transplant , bone marrow transplant rejection, platelet count decreased, sepsis . Busulfex dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, VALPROATE, NEUPOGEN, METHOTREXATE, TACROLIMUS. Patient died.


Busulfex Side Effects Report #5782929-5
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on June 11, 2008. Female patient, 57 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , malaise, nausea , sepsis . Busulfex dosage: 30 ML, INTRAVENOUS. During the same period patient was treated with MELPHALAN. Patient died on 07/19/2006.

Busulfex Side Effects Report #5895530-X
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Sept 10, 2008. Female patient, 57 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, alanine aminotransferase increased, anorexia, aspartate aminotransferase increased, blood bilirubin increased, bone marrow transplant , sepsis . Busulfex dosage: 25.2 ML, DAILY DOSE, INTRAVENOUS. During the same period patient was treated with CYCLOPHOSPHAMIDE, VALPROATE, FILGRASTIM, METHOTREXATE, TACROLIMUS. Patient died.

Busulfex Side Effects Report #5698189-X
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Mar 21, 2008. Male patient, 56 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, blood bilirubin increased, blood urea increased, encephalitis herpes, gamma-glutamyltransferase increased, nausea , sepsis . Busulfex dosage: 20.1 ML INTRAVENOUS. During the same period patient was treated with CYCLOPHOSPHAMIDE, VALPROATE. Patient was hospitalized. Patient died.

Busulfex Side Effects Report #5698112-8
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Mar 21, 2008. Female patient, 55 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, bone marrow transplant , gastrointestinal haemorrhage, sepsis . Busulfex dosage: 30 ML, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Busulfex Side Effects Report #5698172-4
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Mar 21, 2008. Male patient, 49 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: sepsis , stem cell transplant. Busulfex dosage: 32 ML, INTRAVENOUS. Patient was hospitalized. Patient recovered.


Busulfex Side Effects Report #5979835-X
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Nov 12, 2008. Female patient, 44 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, blood urea increased, jaundice , malaise, sepsis , stomatitis. Busulfex dosage: 30 MG, QID, INTRAVENOUS. During the same period patient was treated with DEPAKENE, CYCLOPHOSPHAMIDE, METHOTREXATE, TACROLIMUS, METHYLPREDNISOLONE, CELLCEPT USA. Patient died on 07/16/2007.

Busulfex Side Effects Report #6026259-5
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Dec 18, 2008. Female patient, 44 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: blood urea increased, jaundice , sepsis , stomatitis. Busulfex dosage: 30 MG, QID. During the same period patient was treated with DEPAKENE, CYCLOPHOSPHAMIDE, METHOTREXATE, TACROLIMUS, METHYLPREDNISOLONE, CELLCEPT USA. Patient died on 07/16/2007.

Busulfex Side Effects Report #6092946-6
Busulfex side effect was reported by a Consumer or non-health professional from KOREA, REPUBLIC OF on Feb 11, 2009. Female patient, 43 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: cytomegalovirus infection , disease progression, disease recurrence, pancytopenia, sepsis , stem cell transplant. Busulfex dosage: unknown. During the same period patient was treated with FLUDARABINE PHOSPHATE, THYMOGLOBULIN. Patient died.

Busulfex Side Effects Report #5819426-4
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on July 08, 2008. Male patient, 42 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia recurrent, nausea , sepsis , stomatitis. Busulfex dosage: 150 ML, INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, TACROLIMUS. Patient was hospitalized. Patient recovered.

Busulfex Side Effects Report #6016160-5
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Dec 09, 2008. Male patient, 42 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: nausea , sepsis , stomatitis. Busulfex dosage: 150 ML INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, TACROLIMUS. Patient was hospitalized. Patient recovered.


Busulfex Side Effects Report #6091277-8
Busulfex side effect was reported by a Consumer or non-health professional from KOREA, REPUBLIC OF on Feb 11, 2009. Male patient, 40 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: sepsis . Busulfex dosage: unknown. During the same period patient was treated with FLUDARABINE PHOSPHATE, THYMOGLOBULIN. Patient died.

Busulfex Side Effects Report #5979845-2
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Nov 13, 2008. Male patient, 35 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: enterococcal sepsis, hyperkalaemia, liver disorder, renal failure, stenotrophomonas sepsis, stomatitis, ventricular fibrillation. Busulfex dosage: 34 ML, DAILY DOSE, INTRAVENOUS. During the same period patient was treated with CYCLOSPORINE, FLUDARABINE PHOSPHATE, VALPROATE, FILGRASTIM. Patient died.

Busulfex Side Effects Report #5698234-1
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Mar 21, 2008. Female patient, 33 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: blood bilirubin increased, hepatic function abnormal, sepsis , stem cell transplant. Busulfex dosage: 147.2 ML, INTRAVENOUS. Patient died.

Busulfex Side Effects Report #5907721-X
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Sept 19, 2008. Female patient, child 2 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: cardiac failure, conjunctivitis, ileus, pulmonary oedema, renal failure, sepsis , urethritis, urinary tract infection , venoocclusive liver disease. Busulfex dosage: 0.9 MG/KG, DAILY DOSE INTRAVENOUS. During the same period patient was treated with MELPHALAN, METHYLPREDNISOLONE. Patient recovered.

Busulfex Side Effects Report #5920079-5
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Sept 30, 2008. Female patient, child 2 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: cardiac failure, conjunctivitis, ileus, pulmonary oedema, renal failure, sepsis , venoocclusive liver disease. Busulfex dosage: 0.9 MG/KG, DAILY DOSE, INTRAVENOUS. During the same period patient was treated with MELPHALAN, METHYLPREDNISOLONE. Patient was hospitalized. Patient recovered.


Busulfex Side Effects Report #6092947-8
Busulfex side effect was reported by a Consumer or non-health professional from KOREA, REPUBLIC OF on Feb 11, 2009. Female patient, 19 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: cytomegalovirus infection , disease progression, disease recurrence, pancytopenia, pneumocystis jiroveci pneumonia, rash , sepsis , stem cell transplant. Busulfex dosage: unknown. During the same period patient was treated with FLUDARABINE PHOSPHATE, THYMOGLOBULIN. Patient died.

Busulfex Side Effects Report #5811550-5
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on July 01, 2008. Female patient, 18 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, diarrhoea, malaise, sepsis , stem cell transplant, stomatitis, thrombotic microangiopathy, venoocclusive liver disease. Busulfex dosage: 13 ML, DAILY DOSE; 26 ML, DAILY DOSE. During the same period patient was treated with VALPROATE, MELPHALAN, FILGRASTIM, CYCLOSPORINE. Patient recovered.

Busulfex Side Effects Report #5782932-5
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on June 11, 2008. Male patient, 17 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , diarrhoea, malaise, nausea , sepsis , stomatitis. Busulfex dosage: 40 ML, INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, LENOGRASTIM, METHOTREXATE, TACROLIMUS. Patient recovered.

Busulfex Side Effects Report #5803066-7
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on June 23, 2008. Male patient, 16 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, blood lactate dehydrogenase increased, diarrhoea, hepatic enzyme increased, malaise, nausea , sepsis . Busulfex dosage: 20.1 ML; INTRAVENOUS; 26.8 ML, DAILY DOSE; INTRAVENOUS; 6.7 ML, DAILY DOSE; INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, PHENYTOIN, NEUPOGEN, METHOTREXATE, TACROLIMUS. Patient recovered.

Busulfex Side Effects Report #5920078-3
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Sept 29, 2008. Male patient, 16 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , diarrhoea, hyperglycaemia, liver disorder, nausea , sepsis , sialoadenitis, stomatitis. Busulfex dosage: unknown. During the same period patient was treated with ALKERAN, VALPROATE, NEUTROGIN, METHOTREXATE, TACROLIMUS. Patient was hospitalized. Patient recovered.


Busulfex Side Effects Report #5862338-0
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Aug 12, 2008. Female patient was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, convulsion, diarrhoea, encephalitis viral, graft versus host disease, human herpesvirus 6 infection, malaise, sepsis , stomatitis. Busulfex dosage: 6 ML 46.8 ML, DAILY DOSE; INTRAVENOUS 4.2 ML, DAILY DOSE; INTRAVENOUS. During the same period patient was treated with MELPHALAN, PHENYTOIN, FILGRASTIM, METHOTREXATE, TACROLIMUS. Patient recovered.

Busulfex Side Effects Report #5989260-3
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Nov 25, 2008. Female patient was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute lymphocytic leukaemia recurrent, bone marrow transplant , nausea , neutropenia, pyrexia, respiratory disorder, sepsis , stomatitis, venoocclusive liver disease. Busulfex dosage: 2.4 ML, INTRAVENOUS. During the same period patient was treated with CLONAZEPAM, ZONISAMIDE, ETOPOSIDE, CYCLOPHOSPHAMIDE, FILGRASTIM, METHOTREXATE, TACROLIMUS. Patient recovered.

Busulfex Side Effects Report #5990193-7
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Nov 25, 2008. Female patient was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute lymphocytic leukaemia recurrent, nausea , neutropenia, pyrexia, respiratory disorder, sepsis , stomatitis, venoocclusive liver disease. Busulfex dosage: 2.4 ML. During the same period patient was treated with CLONAZEPAM, ZONISAMIDE, ETOPOSIDE, CYCLOPHOSPHAMIDE, FILGRASTIM, METHOTREXATE, TACROLIMUS. Patient recovered.

Busulfex Side Effects Report #4585874-6
Busulfex side effect was reported by a Physician from on Feb 03, 2005. Male patient, 59 years of age, was diagnosed with multiple myeloma  and was treated with Busulfex. After drug was administered, patient experienced the following side effects: bone marrow transplant , cardiac failure congestive, sepsis , staphylococcal bacteraemia. Busulfex dosage: 264MG/DAY (66MG/DOSE X 4 TIMES)-IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, ATGAM, PHENYTOIN, ZOFRAN, ALLOPURINOL. Patient died on 12/05/2003.