Busulfan and malaise Patient Reports February 12, 2012

Busulfan Side Effects Report #5663403-3
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Feb 22, 2008. Male patient, 62 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: diarrhoea, malaise, pneumonia staphylococcal, stomatitis, viraemia. Busulfan dosage: 32 ML. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5468653-7
Busulfan side effect was reported by a Health Professional from JAPAN on Sept 11, 2007. Female patient, child 6 years of age, was diagnosed with stem cell transplant, prophylaxis against graft versus host disease and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, cytomegalovirus antigen positive, diabetes mellitus, diarrhoea, febrile neutropenia, malaise, oedema mouth, pharyngolaryngeal pain. Busulfan dosage: 10.2 ML; QD; IV; 13.6 ML; QD; IV; 3.4 ML; QD; IV. During the same period patient was treated with MELPHALAN, TACROLIMUS, PHENYTOIN, LENOGRASTIM, METHOTREXATE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5570086-X
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 03, 2007. Female patient, 58 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, aspergillosis, diarrhoea, gastrointestinal haemorrhage, infection , malaise, nausea , stomatitis. Busulfan dosage: 24.4 ML;QD;IV 18.3 ML;QD;IV. Patient died on 04/11/2007.

Busulfan Side Effects Report #5585755-5
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 21, 2007. Male patient, 56 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, adenoviral haemorrhagic cystitis, anorexia, cytomegalovirus viraemia, diarrhoea, enterococcal infection, hepatic function abnormal, malaise, nausea . Busulfan dosage: 36 ML; QD; IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, PHENYTOIN. Patient was hospitalized. Patient recovered.


Busulfan Side Effects Report #5447577-5
Busulfan side effect was reported by a Health Professional from JAPAN on Aug 22, 2007. Male patient, 55 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, cytomegalovirus infection , diarrhoea, malaise, nausea , sepsis , stomatitis. Busulfan dosage: 32.8 ML;. During the same period patient was treated with METHOTREXATE, CYCLOSPORINE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5308978-9
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Apr 06, 2007. Female patient, 54 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acinetobacter infection, anorexia, depressed level of consciousness, graft versus host disease, inappropriate antidiuretic hormone secretion, malaise, nausea , sepsis , thrombotic microangiopathy. Busulfan dosage: unknown. During the same period patient was treated with NEUPOGEN, NEUTROGIN, IMATINIB MESYLATE, VALPROATE, CYCLOPHOSPHAMIDE, METHOTREXATE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5356576-3
Busulfan side effect was reported by a Health Professional from JAPAN on May 29, 2007. Female patient, 54 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, depressed level of consciousness, graft versus host disease, inappropriate antidiuretic hormone secretion, malaise, nausea , sepsis , stem cell transplant, thrombotic microangiopathy. Busulfan dosage: unknown. During the same period patient was treated with NEUPOGEN, NEUTROGIN, IMATINIB MESYLATE, VALPROATE, CYCLOPHOSPHAMIDE, METHOTREXATE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5663405-7
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Feb 22, 2008. Female patient, 54 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant rejection, diarrhoea, malaise, nausea , stomatitis. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, VALPROATE, FILGRASTIM, METHOTREXATE, CYCLOSPORINE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5573171-1
Busulfan side effect was reported by a Health Professional from JAPAN on Dec 06, 2007. Male patient, 53 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, gamma-glutamyltransferase increased, malaise, pneumonia , venoocclusive liver disease. Busulfan dosage: 40 MG; QID; IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, PHENYTOIN, FILGRASTIM, METHOTREXATE, CYCLOSPORINE. Patient was hospitalized and became disabled. Patient recovered.


Busulfan Side Effects Report #5608395-8
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Jan 11, 2008. Male patient, 53 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, malaise, nausea , off label use, pneumonia , staphylococcal sepsis, stomatitis. Busulfan dosage: 7.5 MG;X1;IV. During the same period patient was treated with VALPROATE, FLUDARABINE PHOSPHATE. Patient died on 08/15/2007.

Busulfan Side Effects Report #5308953-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Apr 11, 2007. Male patient, 52 years of age, was diagnosed with stem cell transplant, prophylaxis against graft versus host disease and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bladder hypertrophy, diarrhoea, dysuria, graft versus host disease, liver disorder, malaise, nausea , pollakiuria. Busulfan dosage: 7.7 ML; QID; IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, TACROLIMUS, PHENYTOIN, METHOTREXATE, GRANISETRON. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5586027-5
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 21, 2007. Female patient, 52 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, cytomegalovirus viraemia, diarrhoea, hepatic function abnormal, malaise, nausea , stomatitis. Busulfan dosage: 25.2 ML; X1; IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, PHENYTOIN. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5391697-0
Busulfan side effect was reported by a Health Professional from JAPAN on July 03, 2007. Female patient, 50 years of age, was diagnosed with stem cell transplant, prophylaxis against graft versus host disease and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, cytomegalovirus infection , diarrhoea, malaise, nausea , pseudomembranous colitis, sepsis , stomatitis. Busulfan dosage: 26.4 ML;QD; IV. During the same period patient was treated with METHOTREXATE, FLUDARABINE PHOSPHATE, PHENYTOIN, NEUPOGEN. Patient recovered.

Busulfan Side Effects Report #5564486-1
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 03, 2007. Male patient, child 5 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: cytomegalovirus chorioretinitis, malaise, nausea , sepsis . Busulfan dosage: 9.8 ML; QD; IV. During the same period patient was treated with FLUDARABINE PHOSPHATE. Patient was hospitalized. Patient recovered.


Busulfan Side Effects Report #5391695-7
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on July 03, 2007. Male patient, 49 years of age, was diagnosed with stem cell transplant, graft versus host disease and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant rejection, cytomegalovirus infection , diarrhoea, graft complication, hyperbilirubinaemia, malaise, pain in extremity, pseudomembranous colitis. Busulfan dosage: 40 ML; QD; IV. During the same period patient was treated with NARTOGRASTIM, TRIMETHYLCETYLAMMONIUM PENTACHLOROPHENATE, CLADRIBINE, PHENYTOIN, LENOGRASTIM, FILGRASTIM, TACROLIMUS, MYCOPHENOLATE MOFETIL. Patient recovered.

Busulfan Side Effects Report #5497643-3
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 09, 2007. Male patient, 49 years of age, was diagnosed with stem cell transplant, graft versus host disease and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant rejection, central line infection, cytomegalovirus infection , diarrhoea, gamma-glutamyltransferase increased, hyperbilirubinaemia, malaise, pain in extremity. Busulfan dosage: 40 ML;QD;IV. During the same period patient was treated with NARTOGRASTIM, TRIMETHYLCETYLAMMONIUM PENTACHLOROPHENATE, CLADRIBINE, PHENYTOIN, LENOGRASTIM, NEUPOGEN, TACROLIMUS, MYCOPHENOLATE MOFETIL. Patient was hospitalized and became disabled. Patient recovered.

Busulfan Side Effects Report #5564609-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 03, 2007. Female patient, 48 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, blood bilirubin increased, cellulitis , diarrhoea, hepatomegaly, malaise, nausea , respiratory disorder. Busulfan dosage: 30.8 ML; QD; IV. During the same period patient was treated with FLUDARABINE PHOSPHATE. Patient died on 06/05/2007.

Busulfan Side Effects Report #5332528-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on May 07, 2007. Male patient, 47 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, cardiac failure, liver disorder, malaise, renal disorder, sepsis , staphylococcal sepsis, stem cell transplant, stomatitis. Busulfan dosage: 4 MG; QID; IV. During the same period patient was treated with MELPHALAN, CLADRIBINE, PHENYTOIN, LENOGRASTIM, CIDLOSPORIN. Patient recovered.

Busulfan Side Effects Report #5496982-X
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 09, 2007. Female patient, child 4 years of age, weighting 35.27 lb, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, coagulopathy, diarrhoea, disseminated intravascular coagulation, febrile neutropenia, haematemesis, malaise, multi-organ failure, shock. Busulfan dosage: 4.4 MG/KG; QD; IV. Patient was hospitalized. Patient died.


Busulfan Side Effects Report #5391694-5
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on July 03, 2007. Female patient, 34 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, alanine aminotransferase increased, anorexia, aspartate aminotransferase increased, diarrhoea, enterococcal sepsis, liver disorder, malaise, nausea . Busulfan dosage: 26.8 MG;QD;IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, PHENYTOIN, FILGRASTIM, METHOTREXATE, TACROLIMUS. Patient recovered.

Busulfan Side Effects Report #5413016-3
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on July 26, 2007. Male patient, 30 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, cerebellar ataxia, cytomegalovirus antigen positive, diarrhoea, gastrointestinal candidiasis, graft versus host disease, herpes zoster, malaise, small intestinal haemorrhage. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, METHOTREXATE. Patient recovered.

Busulfan Side Effects Report #5406807-6
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Aug 01, 2007. Male patient, child 3 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant rejection, diarrhoea, hyponatraemia, malaise, nausea . Busulfan dosage: 12 ML;QD;IV. During the same period patient was treated with ETOPOSIDE, CYCLOPHOSPHAMIDE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5564485-X
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 03, 2007. Male patient, 25 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, bone marrow failure, bone marrow transplant , cystitis haemorrhagic, cytomegalovirus infection , diarrhoea, malaise, nausea . Busulfan dosage: 16 ML; QD;IV, 32 ML; QD; IV. Patient recovered.

Busulfan Side Effects Report #5447579-9
Busulfan side effect was reported by a Health Professional from JAPAN on Aug 22, 2007. Female patient, 21 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: cystitis haemorrhagic, diarrhoea, disseminated intravascular coagulation, malaise, multi-organ failure, nausea , neutropenia, staphylococcal sepsis, stem cell transplant. Busulfan dosage: 6.2 ML;BID;IV; 6.2 ML;QID;IV; 6.2 ML;X1;IV. During the same period patient was treated with PHENYTOIN, CYCLOPHOSPHAMIDE, METHOTREXATE, CYCLOSPORINE. Patient died on 05/05/2007.


Busulfan Side Effects Report #5369362-5
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on June 08, 2007. Female patient, child 2 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, febrile neutropenia, herpes zoster, interstitial lung disease, malaise, nausea . Busulfan dosage: 1.2 MG/KG; QID; IV. During the same period patient was treated with FILGRASTIM, CYCLOSPORINE, CYCLOPHOSPHAMIDE. Patient died on 03/19/2007.

Busulfan Side Effects Report #5523802-7
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Nov 05, 2007. Female patient, 18 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, malaise, nausea , nystagmus, staphylococcal sepsis, vertigo. Busulfan dosage: 20 ML; QD; IV. During the same period patient was treated with PHENYTOIN, CYCLOPHOSPHAMIDE, NEUPOGEN, METHOTREXATE, TACROLIMUS. Patient recovered.

Busulfan Side Effects Report #5663691-3
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Feb 22, 2008. Female patient, 16 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , malaise, nausea , nystagmus, staphylococcal sepsis, stomatitis, vertigo. Busulfan dosage: 20 ML;QD;IV. During the same period patient was treated with PHENYTOIN, CYCLOPHOSPHAMIDE, FILGRASTIM, METHOTREXATE, TRACOLIMUS. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5564610-0
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 03, 2007. Male patient, 13 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , malaise, nausea , sepsis , stomatitis. Busulfan dosage: 24.8 ML; QD; IV. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5663402-1
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on June 18, 2007. Male patient, child .5 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anaemia, anorexia, cytomegalovirus viraemia, diarrhoea, gastric haemorrhage, lymphocyte count decreased, malaise, nausea . Busulfan dosage: 1.05 ML; 2.0 ML; 2.4 ML; 0.6 ML. Patient recovered.


Busulfan Side Effects Report #5607486-5
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Jan 11, 2008. Male patient was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, cellulitis , diarrhoea, escherichia sepsis, ileus, malaise, nausea , pneumonia . Busulfan dosage: 27 ML; X1; IV, 6 ML; X1; IV, 9 ML; X1, IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #4830118-0
Busulfan side effect was reported by a Consumer or non-health professional from UNITED STATES on Nov 15, 2005. Male patient, weighting 167.6 lb, was diagnosed with acute myeloid leukaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia recurrent, dysarthria, erythema, haemorrhage intracranial, malaise. Busulfan dosage: unknown. During the same period patient was treated with ETOPOSIDE. Patient was hospitalized. Patient died on 11/13/2005.

Busulfan Side Effects Report #4608622-X
Busulfan side effect was reported by a Consumer or non-health professional from on Mar 11, 2005. Male patient, weighting 280.0 lb, was treated with Busulfan. After drug was administered, patient experienced the following side effects: ascites, blood iron increased, fatigue, hepatic cirrhosis, hepatic failure, hepatorenal syndrome, malaise, pleural effusion, transplant rejection. Busulfan dosage: 1MG/KG PO Q6H X 16 DOSES ON DAYS -7 TO -4.. During the same period patient was treated with ETOPOSIDE, NEUPOGEN. Patient died on 02/17/2005.