Busulfan and graft versus host disease Patient Reports February 12, 2012

Busulfan Side Effects Report #5293766-2
Busulfan side effect was reported by a Consumer or non-health professional from FRANCE on Mar 26, 2007. Male patient, 63 years of age, was diagnosed with stem cell transplant, chronic myelomonocytic leukaemia, graft versus host disease and was treated with Busulfan. After drug was administered, patient experienced the following side effects: cerebral toxoplasmosis, convulsion, graft versus host disease, hemiparesis, leukaemia recurrent. Busulfan dosage: unknown. During the same period patient was treated with CAMPATH, FLUDARABINE PHOSPHATE, CYCLOSPORINE, CYTARABINE, NEUPOGEN, IDARUBICIN, TRIMETOPRIM. Patient died.

Busulfan Side Effects Report #5506440-1
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 23, 2007. Male patient, 63 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, blood lactate dehydrogenase increased, diarrhoea, febrile neutropenia, haemodialysis, haemorrhagic cerebral infarction, intestinal functional disorder, liver disorder. Busulfan dosage: unknown. Patient was hospitalized and became disabled. Patient died.

Busulfan Side Effects Report #5269623-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Mar 08, 2007. Male patient, 54 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: cystitis haemorrhagic, graft versus host disease, thrombotic microangiopathy, venoocclusive liver disease, weight increased. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, CYCLOSPORINE, VALPROATE. Patient died on 12/19/2006.

Busulfan Side Effects Report #5299878-1
Busulfan side effect was reported by a Health Professional from JAPAN on Mar 27, 2007. Male patient, 54 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: cystitis haemorrhagic, diarrhoea, graft versus host disease, hepatic function abnormal, pyrexia, thrombotic microangiopathy, venoocclusive liver disease. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, CYCLOSPORINE, VALPROATE. Patient died on 12/19/2006.


Busulfan Side Effects Report #5308978-9
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Apr 06, 2007. Female patient, 54 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acinetobacter infection, anorexia, depressed level of consciousness, graft versus host disease, inappropriate antidiuretic hormone secretion, malaise, nausea , sepsis , thrombotic microangiopathy. Busulfan dosage: unknown. During the same period patient was treated with NEUPOGEN, NEUTROGIN, IMATINIB MESYLATE, VALPROATE, CYCLOPHOSPHAMIDE, METHOTREXATE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5356576-3
Busulfan side effect was reported by a Health Professional from JAPAN on May 29, 2007. Female patient, 54 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, depressed level of consciousness, graft versus host disease, inappropriate antidiuretic hormone secretion, malaise, nausea , sepsis , stem cell transplant, thrombotic microangiopathy. Busulfan dosage: unknown. During the same period patient was treated with NEUPOGEN, NEUTROGIN, IMATINIB MESYLATE, VALPROATE, CYCLOPHOSPHAMIDE, METHOTREXATE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5308953-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Apr 11, 2007. Male patient, 52 years of age, was diagnosed with stem cell transplant, prophylaxis against graft versus host disease and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bladder hypertrophy, diarrhoea, dysuria, graft versus host disease, liver disorder, malaise, nausea , pollakiuria. Busulfan dosage: 7.7 ML; QID; IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, TACROLIMUS, PHENYTOIN, METHOTREXATE, GRANISETRON. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5324437-1
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Apr 24, 2007. Male patient, 52 years of age, was diagnosed with stem cell transplant, prophylaxis against graft versus host disease and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bladder hypertrophy, cytomegalovirus antigen positive, diarrhoea, dysuria, erythema, graft versus host disease, interstitial lung disease, liver disorder. Busulfan dosage: 7.7 ML; QID; IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, TACROLIMUS, PHENYTOIN, METHOTREXATE, GRANISETRON. Patient died on 04/20/2007.

Busulfan Side Effects Report #5369891-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on June 07, 2007. Male patient, 52 years of age, was diagnosed with stem cell transplant, prophylaxis against graft versus host disease and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, cytomegalovirus antigen positive, diarrhoea, dysuria, erythema, graft versus host disease, interstitial lung disease, liver disorder, malaise. Busulfan dosage: 7.7 ML; QID; IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, TACROLIMUS, PHENYTOIN, METHOTREXATE, GRANISETRON. Patient died on 04/22/2007.


Busulfan Side Effects Report #5608392-2
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Jan 11, 2008. Female patient, 51 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: bone marrow transplant , graft versus host disease, haemorrhage, herpes virus infection, liver disorder, myelodysplastic syndrome, pneumonia , respiratory depression, stomatitis. Busulfan dosage: 27.68 ML;X1;IV. During the same period patient was treated with VALPROATE, FLUDARABINE PHOSPHATE. Patient died on 07/26/2007.

Busulfan Side Effects Report #5196208-0
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 14, 2006. Male patient, 49 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: diarrhoea, duodenal ulcer, graft versus host disease, renal impairment. Busulfan dosage: 3.2 MG/KG;QID;IV. During the same period patient was treated with CYCLOSPORINE. Patient died on 12/05/2006.

Busulfan Side Effects Report #5259876-0
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Feb 20, 2007. Male patient, 44 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: graft versus host disease, septic shock, stem cell transplant. Busulfan dosage: 5 ML; IV. During the same period patient was treated with PHENYTOIN, CYCLOPHOSPHAMIDE. Patient died.

Busulfan Side Effects Report #5369892-6
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on June 07, 2007. Male patient, 40 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, bone marrow transplant rejection, peritonitis, tumour lysis syndrome, venoocclusive liver disease. Busulfan dosage: 216 MG; QD; IV. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5523800-3
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Nov 05, 2007. Male patient, child 4 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia recurrent, graft versus host disease, sepsis , stomatitis. Busulfan dosage: 9.63 ML; QD; IV, 12.84 ML; QD; IV, 3.21 ML; QD; IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, CYTARABINE, CLONAZEPAM, NEUPOGEN, METHOTREXATE. Patient was hospitalized. Patient died on 07/26/2007.


Busulfan Side Effects Report #5413016-3
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on July 26, 2007. Male patient, 30 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, cerebellar ataxia, cytomegalovirus antigen positive, diarrhoea, gastrointestinal candidiasis, graft versus host disease, herpes zoster, malaise, small intestinal haemorrhage. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, METHOTREXATE. Patient recovered.

Busulfan Side Effects Report #4626768-7
Busulfan side effect was reported by a Consumer or non-health professional from on Mar 16, 2005. Female patient, child 3 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: clostridium colitis, graft versus host disease, pneumocystis jiroveci pneumonia, skin disorder. Busulfan dosage: 4 MG/KG IV. Patient recovered.

Busulfan Side Effects Report #5024190-5
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Mar 18, 2005. Female patient, child 3 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: graft versus host disease, pneumocystis jiroveci pneumonia. Busulfan dosage: 4 MG/KG; QD; PO. During the same period patient was treated with CYCLOPHOSPHAMIDE, METHOTREXATE, CYCLOSPORINE. Patient recovered.

Busulfan Side Effects Report #4627429-0
Busulfan side effect was reported by a Physician from on Mar 16, 2005. Female patient, 19 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: graft versus host disease, thrombotic microangiopathy. Busulfan dosage: 4 MG/KG IV. Patient recovered.

Busulfan Side Effects Report #4627430-7
Busulfan side effect was reported by a Physician from on Mar 16, 2005. Female patient, 18 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: disease recurrence, graft versus host disease, pneumocystis jiroveci pneumonia, pneumothorax, thrombotic microangiopathy. Busulfan dosage: 4 MG/KG IV. Patient recovered.


Busulfan Side Effects Report #5503593-6
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 15, 2007. Male patient, 15 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, cystitis, cystitis haemorrhagic, diarrhoea, graft versus host disease, nausea , pneumonia , sepsis , stomatitis haemorrhagic. Busulfan dosage: 27.48 ML;QD;IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, PHENYTOIN, NEUPOGEN, TACROLIMUS. Patient recovered.

Busulfan Side Effects Report #4626767-5
Busulfan side effect was reported by a Consumer or non-health professional from on Mar 16, 2005. Female patient, 15 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, bronchopneumonia, bronchopulmonary aspergillosis, gastrointestinal candidiasis, graft versus host disease, lung infection pseudomonal, transplant failure, venoocclusive disease. Busulfan dosage: 4 MG/KG IV. Patient died.

Busulfan Side Effects Report #5608391-0
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Jan 11, 2008. Male patient, child .4 years of age, weighting 9.04 lb, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood pressure decreased, cardiac arrest , delayed engraftment, diarrhoea, graft versus host disease, hypoglycaemia. Busulfan dosage: 1.0 MG/KG;QID;IV. During the same period patient was treated with POLYMYXIN B SULPHATE, VANCOMYCIN HYDROCHLORIDE, TAUROURSODESOXYCHOLIC ACID, FLUCONAZOLE, FLUDARABINE PHOSPHATE. Patient died on 12/02/2007.

Busulfan Side Effects Report #5679929-2
Busulfan side effect was reported by a Consumer or non-health professional from CANADA on Mar 13, 2008. Female patient was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: graft versus host disease, lymphoproliferative disorder. Busulfan dosage: 3.2 MG/KG; X1; IV. During the same period patient was treated with FLUDARABINE. Patient died.

Busulfan Side Effects Report #5679930-9
Busulfan side effect was reported by a Consumer or non-health professional from CANADA on Mar 13, 2008. Female patient was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: graft versus host disease, lymphoproliferative disorder. Busulfan dosage: 3.2 MG/KG; X1; IV. During the same period patient was treated with FLUDARABINE. Patient died.


Busulfan Side Effects Report #5827104-0
Busulfan side effect was reported by a Consumer or non-health professional from UNITED STATES on July 29, 2008. Male patient, weighting 156.1 lb, was diagnosed with myelofibrosis and was treated with Busulfan. After drug was administered, patient experienced the following side effects: abdominal pain , clostridium difficile toxin test positive, graft versus host disease, haematemesis. Busulfan dosage: 66MG 16X Q6HR ORAL. During the same period patient was treated with CYCLOPHOSPHAMIDE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5024192-9
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Mar 23, 2005. Female patient, 50 years of age, was diagnosed with bone marrow conditioning regimen and was treated with Busulfan. After drug was administered, patient experienced the following side effects: graft versus host disease. Busulfan dosage: 170.4 MG; QD; IV. During the same period patient was treated with TRIMETHOPRIM, FAMOTIDINE, PREDNISOLONE, CYCLOSPORINE, ACYCLOVIR, FLUCONAZOLE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5024200-5
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Apr 01, 2005. Male patient, 32 years of age, was diagnosed with bone marrow conditioning regimen and was treated with Busulfan. After drug was administered, patient experienced the following side effects: graft versus host disease. Busulfan dosage: 184 MG; QD. During the same period patient was treated with CYCLOPHOSPHAMIDE, MESNA, PHENYTOIN, ZOFRAN, VANCOMYCIN, MEROPENEM, CEFTAZIDIME, CIPROFLOXACIN. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5024198-X
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Apr 01, 2005. Male patient, 31 years of age, was diagnosed with bone marrow conditioning regimen and was treated with Busulfan. After drug was administered, patient experienced the following side effects: graft versus host disease. Busulfan dosage: 300 MG; QD;. During the same period patient was treated with CYCLOPHOSPHAMIDE, MESNA, PHENYTOIN, ZOFRAN, HEPARIN, GRASIN, ANTIBIOTICS, ANTIFUNGALS. Patient died on 03/28/2003.

Busulfan Side Effects Report #5024195-4
Busulfan side effect was reported by a Consumer or non-health professional from UNITED STATES on Mar 24, 2005. Male patient, 29 years of age, was diagnosed with bone marrow conditioning regimen and was treated with Busulfan. After drug was administered, patient experienced the following side effects: graft versus host disease. Busulfan dosage: 184.8 MG; QD. During the same period patient was treated with CYCLOPHOSPHAMIDE, MESNA. Patient died on 08/19/2003.


Busulfan Side Effects Report #5024197-8
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Apr 01, 2005. Male patient, 28 years of age, was diagnosed with bone marrow conditioning regimen and was treated with Busulfan. After drug was administered, patient experienced the following side effects: graft versus host disease. Busulfan dosage: 236 MG; QD. During the same period patient was treated with MESNA, CYCLOPHOSPHAMIDE, PHENYTOIN, ZOFRAN, VANCOMYCIN, MEROPENEM, CEFTAZIDIME, CIPROFLOXACIN. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5108881-3
Busulfan side effect was reported by a Health Professional from UNITED STATES on Sept 15, 2006. Male patient, 55 years of age, weighting 191.6 lb, was diagnosed with acute myeloid leukaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: amnesia, blood bilirubin abnormal, gastrointestinal haemorrhage, graft versus host disease, post procedural complication. Busulfan dosage: 50 MG /PO. During the same period patient was treated with BUSULFAN MUD TRANSPLANT, CYTOXAN, TACROLIMUS, METHYLPREDNISOLONE, REMICADE, TRIAMCINOLONE, DESONIDE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5859263-8
Busulfan side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 26, 2008. Female patient, weighting 219.8 lb, was diagnosed with acute myeloid leukaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: diarrhoea, graft versus host disease, nausea , weight decreased. Busulfan dosage: 52 MG 16 DOSES /6 HR ORAL. During the same period patient was treated with CYCLOPHOSPHAMIDE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #4744402-2
Busulfan side effect was reported by a Health Professional from UNITED STATES on Aug 11, 2005. Female patient, weighting 154.3 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: asthenia, blood bilirubin increased, blood culture positive, fatigue, graft versus host disease, hypotension, nausea , neutropenia, oxygen saturation decreased. Busulfan dosage: unknown. During the same period patient was treated with CAMPATH, FLUDARABINE PHOSPHATE, PREDNISONE, ANTIBIOTICS, MORPHINE. Patient died on 08/05/2005.

Busulfan Side Effects Report #4735884-0
Busulfan side effect was reported by a Health Professional from UNITED STATES on Aug 04, 2005. Female patient, weighting 0.15 lb, was diagnosed with acute leukaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: graft versus host disease, hyperbilirubinaemia, rash . Busulfan dosage: 35 MG ONCE INTRAVENOUS. Patient was hospitalized. Patient recovered.


Busulfan Side Effects Report #4685905-9
Busulfan side effect was reported by a Health Professional from on June 01, 2005. Male patient, 56 years of age, weighting 190.9 lb, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: bacteraemia, blood bilirubin abnormal, gastrointestinal haemorrhage, graft versus host disease, infection , liver disorder, loss of consciousness, skin disorder. Busulfan dosage: unknown. During the same period patient was treated with CYTOXAN, ACYCLOVIR, CIPROFLOXACIN, VANCOMYCIN, ABELCET, NADOLOL, ACTIGALL, TACROLIMUS. Patient was hospitalized. Patient died on 06/01/2005.

Busulfan Side Effects Report #5630595-1
Busulfan side effect was reported by a Physician from SLOVAKIA (Slovak Republic) on Feb 15, 2008. Female patient, 52 years of age, weighting 132.3 lb, was treated with Busulfan. After drug was administered, patient experienced the following side effects: convulsion, gastrointestinal haemorrhage, graft versus host disease, subarachnoid haemorrhage. Busulfan dosage: 120MG PER DAY. During the same period patient was treated with CYCLOPHOSPHAMIDE, ALDESLEUKIN, CYCLOSPORINE, METHOTREXATE, FRAXIPARINE. Patient recovered.

Busulfan Side Effects Report #4760149-0
Busulfan side effect was reported by a Health Professional from UNITED STATES on Aug 31, 2005. Male patient, 32 years of age, weighting 192.2 lb, was diagnosed with chronic myeloid leukaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: graft complication, graft versus host disease. Busulfan dosage: 52MG. During the same period patient was treated with CYTOXAN. Patient died on 08/05/2005.

Busulfan Side Effects Report #4883156-6
Busulfan side effect was reported by a Health Professional from UNITED STATES on Jan 17, 2006. Female patient, 31 years of age, weighting 217.6 lb, was treated with Busulfan. After drug was administered, patient experienced the following side effects: cholecystitis acute, gastrointestinal disorder, graft versus host disease. Busulfan dosage: 56 MG/IV. During the same period patient was treated with CYTOXAN, VANCOMYCIN, ACYCLOVIR, CYCLOSPORINE, CIPROFLOXACIN, CASPOFUNGIN, IMIPENEM. Patient died on 01/13/2006.