Busulfan and febrile neutropenia Patient Reports February 12, 2012

Busulfan Side Effects Report #5586026-3
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 21, 2007. Male patient, child 8 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, blister, diabetes mellitus, diarrhoea, febrile neutropenia, haematochezia, hepatic function abnormal, malaise. Busulfan dosage: 12 ML; IV, 16 ML; IV, 4 ML; IV. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5608393-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Jan 11, 2008. Male patient, child 7 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, coagulopathy, continuous haemodiafiltration, febrile neutropenia, gastritis, haemosiderosis, hepatic function abnormal, hyperbilirubinaemia, hypoproteinaemia. Busulfan dosage: 6 ML; IV. Patient was hospitalized. Patient died on 11/29/2007.

Busulfan Side Effects Report #5422205-3
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Aug 03, 2007. Male patient, 63 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, blood lactate dehydrogenase increased, bone marrow transplant , diarrhoea, febrile neutropenia, gastrointestinal disorder, haemodialysis, haemorrhagic cerebral infarction, liver disorder. Busulfan dosage: unknown. Patient recovered.

Busulfan Side Effects Report #5506440-1
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 23, 2007. Male patient, 63 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, blood lactate dehydrogenase increased, diarrhoea, febrile neutropenia, haemodialysis, haemorrhagic cerebral infarction, intestinal functional disorder, liver disorder. Busulfan dosage: unknown. Patient was hospitalized and became disabled. Patient died.


Busulfan Side Effects Report #5468640-9
Busulfan side effect was reported by a Health Professional from JAPAN on Sept 11, 2007. Male patient, 60 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: blood creatinine increased, blood culture positive, blood sodium increased, bone marrow transplant , decreased appetite, diarrhoea, escherichia infection, febrile neutropenia, haemodialysis. Busulfan dosage: 27 ML; QD; IV; 36 ML; QD; IV; 9 ML; QD; IV. During the same period patient was treated with NEUPOGEN, FLUDARABINE PHOSPHATE, CYTARABINE, VALPROATE, METHOTREXATE, TACROLIMUS. Patient died.

Busulfan Side Effects Report #5468653-7
Busulfan side effect was reported by a Health Professional from JAPAN on Sept 11, 2007. Female patient, child 6 years of age, was diagnosed with stem cell transplant, prophylaxis against graft versus host disease and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, cytomegalovirus antigen positive, diabetes mellitus, diarrhoea, febrile neutropenia, malaise, oedema mouth, pharyngolaryngeal pain. Busulfan dosage: 10.2 ML; QD; IV; 13.6 ML; QD; IV; 3.4 ML; QD; IV. During the same period patient was treated with MELPHALAN, TACROLIMUS, PHENYTOIN, LENOGRASTIM, METHOTREXATE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5497678-0
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 09, 2007. Female patient, 55 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, arthritis bacterial, cardiac failure, cytomegalovirus viraemia, diarrhoea, febrile neutropenia, hyponatraemia. Busulfan dosage: 10.6 ML;X1;IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, CYCLOSPORINE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5608390-9
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Jan 11, 2008. Female patient, child 5 years of age, weighting 35.27 lb, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: coagulopathy, diarrhoea, disseminated intravascular coagulation, febrile neutropenia, hyperchloraemia, hypernatraemia, hypokalaemia, multi-organ failure, refractoriness to platelet transfusion. Busulfan dosage: 8.4 ML;X1;IV; 11.2 ML;X1;IV; 2.8 ML;X1;IV. During the same period patient was treated with CLONAZEPAM. Patient was hospitalized. Patient died on 08/27/2007.

Busulfan Side Effects Report #5570090-1
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 04, 2007. Female patient, 43 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bacterial sepsis, cytomegalovirus viraemia, diarrhoea, febrile neutropenia, hepatic function abnormal, hyperglycaemia, nausea , platelet count decreased. Busulfan dosage: 18.9 ML; 25.2 ML; 6.3 ML; QD; IV. During the same period patient was treated with VALPROATE. Patient was hospitalized. Patient recovered.


Busulfan Side Effects Report #5586032-9
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 21, 2007. Female patient, 43 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: altered state of consciousness, febrile neutropenia, grand mal convulsion, pruritus, stomatitis, thrombotic microangiopathy, venoocclusive liver disease. Busulfan dosage: 26.68 ML; IV. Patient recovered.

Busulfan Side Effects Report #5496982-X
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 09, 2007. Female patient, child 4 years of age, weighting 35.27 lb, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, coagulopathy, diarrhoea, disseminated intravascular coagulation, febrile neutropenia, haematemesis, malaise, multi-organ failure, shock. Busulfan dosage: 4.4 MG/KG; QD; IV. Patient was hospitalized. Patient died.

Busulfan Side Effects Report #5468657-4
Busulfan side effect was reported by a Health Professional from JAPAN on Sept 11, 2007. Female patient, 30 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: febrile neutropenia, haptoglobin decreased, platelet count decreased, red blood cell schistocytes present, thrombotic microangiopathy. Busulfan dosage: 26.12 ML;QD;IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, VALPROATE, NEUPOGEN, METHOTREXATE, CICLOSPORIN. Patient died.

Busulfan Side Effects Report #5585760-9
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 21, 2007. Male patient, 24 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, bone marrow transplant rejection, cytomegalovirus infection , febrile neutropenia, liver disorder, nausea , pancytopenia, stomatitis. Busulfan dosage: 8.13 ML; ; IV. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5369362-5
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on June 08, 2007. Female patient, child 2 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, febrile neutropenia, herpes zoster, interstitial lung disease, malaise, nausea . Busulfan dosage: 1.2 MG/KG; QID; IV. During the same period patient was treated with FILGRASTIM, CYCLOSPORINE, CYCLOPHOSPHAMIDE. Patient died on 03/19/2007.


Busulfan Side Effects Report #4718327-2
Busulfan side effect was reported by a Health Professional from UNITED STATES on July 18, 2005. Female patient was diagnosed with chronic myeloid leukaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: dyspnoea, febrile neutropenia. Busulfan dosage: 0.5 MG/KG 1 DOSE IV. Patient recovered.

Busulfan Side Effects Report #4703124-4
Busulfan side effect was reported by a Consumer or non-health professional from on Apr 19, 2004. Male patient was diagnosed with bone marrow transplant  and was treated with Busulfan. After drug was administered, patient experienced the following side effects: bone marrow depression, febrile neutropenia, gastrointestinal toxicity, mucosal inflammation, pain , sepsis . Busulfan dosage: 4MGK PER DAY. During the same period patient was treated with MELPHALAN. Patient died.

Busulfan Side Effects Report #4893403-2
Busulfan side effect was reported by a Consumer or non-health professional from UNITED STATES on Jan 25, 2006. Female patient, weighting 130.1 lb, was diagnosed with acute myeloid leukaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: abdominal pain , abdominal tenderness, diarrhoea, febrile neutropenia, rash pustular, stem cell transplant, tonsillar disorder, white blood cell count decreased. Busulfan dosage: unknown. During the same period patient was treated with ETOPOSIDE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5408208-3
Busulfan side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 06, 2007. Female patient, weighting 127.9 lb, was treated with Busulfan. After drug was administered, patient experienced the following side effects: clostridium difficile colitis, enterocutaneous fistula, febrile neutropenia, metabolic disorder , sepsis , stem cell transplant. Busulfan dosage: 640 MG. During the same period patient was treated with CYTARABINE, ETOPOSIDE. Patient died on 07/14/2007.

Busulfan Side Effects Report #5474509-6
Busulfan side effect was reported by a Consumer or non-health professional from UNITED STATES on Sept 28, 2007. Female patient, weighting 201.1 lb, was treated with Busulfan. After drug was administered, patient experienced the following side effects: atelectasis, febrile neutropenia, haemoglobin decreased, mucosal inflammation, platelet count decreased, white blood cell count decreased, white blood cell count increased. Busulfan dosage: 864 MG. During the same period patient was treated with ETOPOSIDE. Patient was hospitalized. Patient recovered.