Busulfan and disseminated intravascular coagulation Patient Reports February 12, 2012

Busulfan Side Effects Report #5586040-8
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 21, 2007. Female patient, 64 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, acute respiratory distress syndrome, bone marrow transplant , candidiasis, convulsion, disseminated intravascular coagulation, neutropenia, pancreatitis acute. Busulfan dosage: 10 ML; IV, 20 ML; IV. Patient died.

Busulfan Side Effects Report #5281145-3
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Mar 09, 2007. Male patient, 59 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: azotaemia, cardiac failure, disseminated intravascular coagulation, infection , multi-organ failure, oedema mouth, pyrexia, renal failure, stomatitis. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE. Patient was hospitalized. Patient died on 03/01/2007.

Busulfan Side Effects Report #5332531-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on May 07, 2007. Male patient, 59 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, antibody test positive, blood pressure decreased, capillary leak syndrome, cardiac arrest , cardiac failure, crossmatch incompatible, disseminated intravascular coagulation. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, HEPARIN. Patient was hospitalized. Patient died on 03/01/2007.

Busulfan Side Effects Report #5391672-6
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on July 02, 2007. Male patient, 59 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, capillary leak syndrome, cardiac failure, diarrhoea, disseminated intravascular coagulation, gastroenteritis staphylococcal, haemolysis, haemorrhoids, liver disorder. Busulfan dosage: 46 MG;QID;IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, HEPARIN. Patient was hospitalized. Patient died on 03/01/2007.


Busulfan Side Effects Report #5503591-2
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 15, 2007. Male patient, 59 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: azotaemia, capillary leak syndrome, cardiac arrest , cardiac failure, disseminated intravascular coagulation, gastroenteritis staphylococcal, gastrointestinal haemorrhage. Busulfan dosage: 46 MG; QID; IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, HEPARIN. Patient was hospitalized. Patient died on 03/01/2007.

Busulfan Side Effects Report #5608390-9
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Jan 11, 2008. Female patient, child 5 years of age, weighting 35.27 lb, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: coagulopathy, diarrhoea, disseminated intravascular coagulation, febrile neutropenia, hyperchloraemia, hypernatraemia, hypokalaemia, multi-organ failure, refractoriness to platelet transfusion. Busulfan dosage: 8.4 ML;X1;IV; 11.2 ML;X1;IV; 2.8 ML;X1;IV. During the same period patient was treated with CLONAZEPAM. Patient was hospitalized. Patient died on 08/27/2007.

Busulfan Side Effects Report #5585749-X
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 21, 2007. Male patient, 43 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: brain stem haemorrhage, cystitis haemorrhagic, disseminated intravascular coagulation, gastrointestinal haemorrhage, infection , pulmonary haemorrhage, sepsis . Busulfan dosage: 29.32 ML; QD; IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE. Patient died on 12/17/2006.

Busulfan Side Effects Report #5496982-X
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 09, 2007. Female patient, child 4 years of age, weighting 35.27 lb, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, coagulopathy, diarrhoea, disseminated intravascular coagulation, febrile neutropenia, haematemesis, malaise, multi-organ failure, shock. Busulfan dosage: 4.4 MG/KG; QD; IV. Patient was hospitalized. Patient died.

Busulfan Side Effects Report #5363111-2
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on June 01, 2007. Female patient, 21 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, multi-organ failure, neutrophil count decreased, staphylococcal sepsis. Busulfan dosage: unknown. During the same period patient was treated with PHENYTOIN, CYCLOPHOSPHAMIDE, METHOTREXATE, CYCLOSPORINE. Patient died on 05/05/2007.


Busulfan Side Effects Report #5447579-9
Busulfan side effect was reported by a Health Professional from JAPAN on Aug 22, 2007. Female patient, 21 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: cystitis haemorrhagic, diarrhoea, disseminated intravascular coagulation, malaise, multi-organ failure, nausea , neutropenia, staphylococcal sepsis, stem cell transplant. Busulfan dosage: 6.2 ML;BID;IV; 6.2 ML;QID;IV; 6.2 ML;X1;IV. During the same period patient was treated with PHENYTOIN, CYCLOPHOSPHAMIDE, METHOTREXATE, CYCLOSPORINE. Patient died on 05/05/2007.

Busulfan Side Effects Report #5235928-6
Busulfan side effect was reported by a Health Professional from GERMANY on Jan 30, 2007. Female patient was diagnosed with bone marrow conditioning regimen, bone marrow transplant  and was treated with Busulfan. After drug was administered, patient experienced the following side effects: blood bilirubin increased, disseminated intravascular coagulation, hepatic function abnormal, life support, oliguria, renal failure, respiratory failure, thrombocytopenic purpura, venoocclusive disease. Busulfan dosage: 16 MG/KG/D. During the same period patient was treated with CYCLOPHOSPHAMIDE, ATGAM, METHOTREXATE, CYCLOSPORINE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5082672-4
Busulfan side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 16, 2006. Female patient, weighting 160.9 lb, was treated with Busulfan. After drug was administered, patient experienced the following side effects: bronchopneumonia, diffuse alveolar damage, disseminated intravascular coagulation, gamma-glutamyltransferase increased, haemorrhage, hyperglycaemia, hypoxia, renal failure, sepsis . Busulfan dosage: 1.6 MG. During the same period patient was treated with FLUDARABINE PHOSPHATE. Patient was hospitalized. Patient recovered.