Busulfan and diarrhoea Patient Reports February 12, 2012

Busulfan Side Effects Report #5586026-3
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 21, 2007. Male patient, child 8 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, blister, diabetes mellitus, diarrhoea, febrile neutropenia, haematochezia, hepatic function abnormal, malaise. Busulfan dosage: 12 ML; IV, 16 ML; IV, 4 ML; IV. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5607479-8
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Jan 11, 2008. Male patient, 64 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bacterial sepsis, blood lactate dehydrogenase increased, blood pressure decreased, cellulitis , diarrhoea, haemodialysis, hepatic function abnormal. Busulfan dosage: 2.4 ML; X1; I V, 3.2 ML; X1; IV, 0.8 ML; X1; IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, LORAZEPAM. Patient was hospitalized. Patient died on 11/27/2007.

Busulfan Side Effects Report #5422205-3
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Aug 03, 2007. Male patient, 63 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, blood lactate dehydrogenase increased, bone marrow transplant , diarrhoea, febrile neutropenia, gastrointestinal disorder, haemodialysis, haemorrhagic cerebral infarction, liver disorder. Busulfan dosage: unknown. Patient recovered.

Busulfan Side Effects Report #5506440-1
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 23, 2007. Male patient, 63 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, blood lactate dehydrogenase increased, diarrhoea, febrile neutropenia, haemodialysis, haemorrhagic cerebral infarction, intestinal functional disorder, liver disorder. Busulfan dosage: unknown. Patient was hospitalized and became disabled. Patient died.


Busulfan Side Effects Report #5663403-3
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Feb 22, 2008. Male patient, 62 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: diarrhoea, malaise, pneumonia staphylococcal, stomatitis, viraemia. Busulfan dosage: 32 ML. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5468640-9
Busulfan side effect was reported by a Health Professional from JAPAN on Sept 11, 2007. Male patient, 60 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: blood creatinine increased, blood culture positive, blood sodium increased, bone marrow transplant , decreased appetite, diarrhoea, escherichia infection, febrile neutropenia, haemodialysis. Busulfan dosage: 27 ML; QD; IV; 36 ML; QD; IV; 9 ML; QD; IV. During the same period patient was treated with NEUPOGEN, FLUDARABINE PHOSPHATE, CYTARABINE, VALPROATE, METHOTREXATE, TACROLIMUS. Patient died.

Busulfan Side Effects Report #5468653-7
Busulfan side effect was reported by a Health Professional from JAPAN on Sept 11, 2007. Female patient, child 6 years of age, was diagnosed with stem cell transplant, prophylaxis against graft versus host disease and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, cytomegalovirus antigen positive, diabetes mellitus, diarrhoea, febrile neutropenia, malaise, oedema mouth, pharyngolaryngeal pain. Busulfan dosage: 10.2 ML; QD; IV; 13.6 ML; QD; IV; 3.4 ML; QD; IV. During the same period patient was treated with MELPHALAN, TACROLIMUS, PHENYTOIN, LENOGRASTIM, METHOTREXATE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5391672-6
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on July 02, 2007. Male patient, 59 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, capillary leak syndrome, cardiac failure, diarrhoea, disseminated intravascular coagulation, gastroenteritis staphylococcal, haemolysis, haemorrhoids, liver disorder. Busulfan dosage: 46 MG;QID;IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, HEPARIN. Patient was hospitalized. Patient died on 03/01/2007.

Busulfan Side Effects Report #5570086-X
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 03, 2007. Female patient, 58 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, aspergillosis, diarrhoea, gastrointestinal haemorrhage, infection , malaise, nausea , stomatitis. Busulfan dosage: 24.4 ML;QD;IV 18.3 ML;QD;IV. Patient died on 04/11/2007.


Busulfan Side Effects Report #5466146-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Sept 10, 2007. Female patient, 56 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, diarrhoea, haemodialysis, pneumonia , renal failure acute, sepsis , stomatitis. Busulfan dosage: 26.4 ML; QD; IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, NEUPOGEN, VALPROATE, METHOTREXATE, TACROLIMUS, CYCLOSPORINE. Patient died on 06/15/2007.

Busulfan Side Effects Report #5585755-5
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 21, 2007. Male patient, 56 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, adenoviral haemorrhagic cystitis, anorexia, cytomegalovirus viraemia, diarrhoea, enterococcal infection, hepatic function abnormal, malaise, nausea . Busulfan dosage: 36 ML; QD; IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, PHENYTOIN. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5447577-5
Busulfan side effect was reported by a Health Professional from JAPAN on Aug 22, 2007. Male patient, 55 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, cytomegalovirus infection , diarrhoea, malaise, nausea , sepsis , stomatitis. Busulfan dosage: 32.8 ML;. During the same period patient was treated with METHOTREXATE, CYCLOSPORINE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5497678-0
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 09, 2007. Female patient, 55 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, arthritis bacterial, cardiac failure, cytomegalovirus viraemia, diarrhoea, febrile neutropenia, hyponatraemia. Busulfan dosage: 10.6 ML;X1;IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, CYCLOSPORINE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5299878-1
Busulfan side effect was reported by a Health Professional from JAPAN on Mar 27, 2007. Male patient, 54 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: cystitis haemorrhagic, diarrhoea, graft versus host disease, hepatic function abnormal, pyrexia, thrombotic microangiopathy, venoocclusive liver disease. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, CYCLOSPORINE, VALPROATE. Patient died on 12/19/2006.


Busulfan Side Effects Report #5385416-1
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on June 26, 2007. Male patient, 54 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: abdominal pain upper, ascites, blood bilirubin increased, blood lactate dehydrogenase increased, cystitis haemorrhagic, cytomegalovirus antibody positive, cytomegalovirus infection , diarrhoea, graft versus host disease. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, CYCLOSPORINE, VALPROATE. Patient died on 12/19/2006.

Busulfan Side Effects Report #5523823-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Nov 05, 2007. Female patient, 54 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: blood bilirubin increased, bronchopulmonary aspergillosis, diarrhoea, hepatic function abnormal, hypokalaemia, pancytopenia, stomatitis, streptococcal sepsis. Busulfan dosage: 24.4 ML;QD;IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, PHENYTOIN, NEUPOGEN, LENOGRASTIM, METHOTREXATE, TACROLIMUS. Patient recovered.

Busulfan Side Effects Report #5663405-7
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Feb 22, 2008. Female patient, 54 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant rejection, diarrhoea, malaise, nausea , stomatitis. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, VALPROATE, FILGRASTIM, METHOTREXATE, CYCLOSPORINE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5308953-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Apr 11, 2007. Male patient, 52 years of age, was diagnosed with stem cell transplant, prophylaxis against graft versus host disease and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bladder hypertrophy, diarrhoea, dysuria, graft versus host disease, liver disorder, malaise, nausea , pollakiuria. Busulfan dosage: 7.7 ML; QID; IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, TACROLIMUS, PHENYTOIN, METHOTREXATE, GRANISETRON. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5324437-1
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Apr 24, 2007. Male patient, 52 years of age, was diagnosed with stem cell transplant, prophylaxis against graft versus host disease and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bladder hypertrophy, cytomegalovirus antigen positive, diarrhoea, dysuria, erythema, graft versus host disease, interstitial lung disease, liver disorder. Busulfan dosage: 7.7 ML; QID; IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, TACROLIMUS, PHENYTOIN, METHOTREXATE, GRANISETRON. Patient died on 04/20/2007.


Busulfan Side Effects Report #5369891-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on June 07, 2007. Male patient, 52 years of age, was diagnosed with stem cell transplant, prophylaxis against graft versus host disease and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, cytomegalovirus antigen positive, diarrhoea, dysuria, erythema, graft versus host disease, interstitial lung disease, liver disorder, malaise. Busulfan dosage: 7.7 ML; QID; IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, TACROLIMUS, PHENYTOIN, METHOTREXATE, GRANISETRON. Patient died on 04/22/2007.

Busulfan Side Effects Report #5496980-6
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 09, 2007. Female patient, 52 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , diarrhoea, enterococcal sepsis, nausea , pathogen resistance, respiratory failure, staphylococcal sepsis, stomatitis. Busulfan dosage: 26.8 ML; X1; IV. During the same period patient was treated with FLUDARABINE PHOSPHATE. Patient was hospitalized and became disabled. Patient died on 08/11/2007.

Busulfan Side Effects Report #5586027-5
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 21, 2007. Female patient, 52 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, cytomegalovirus viraemia, diarrhoea, hepatic function abnormal, malaise, nausea , stomatitis. Busulfan dosage: 25.2 ML; X1; IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, PHENYTOIN. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5391696-9
Busulfan side effect was reported by a Health Professional from JAPAN on July 03, 2007. Female patient, 51 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, blood pressure decreased, bone marrow transplant rejection, cardiac arrest , condition aggravated, diarrhoea, respiratory arrest, sepsis . Busulfan dosage: 26.68 ML;QD;IV. During the same period patient was treated with VALPROATE, CYCLOPHOSPHAMIDE, METHOTREXATE, CYCLOSPORINE. Patient was hospitalized. Patient died on 04/09/2007.

Busulfan Side Effects Report #5391697-0
Busulfan side effect was reported by a Health Professional from JAPAN on July 03, 2007. Female patient, 50 years of age, was diagnosed with stem cell transplant, prophylaxis against graft versus host disease and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, cytomegalovirus infection , diarrhoea, malaise, nausea , pseudomembranous colitis, sepsis , stomatitis. Busulfan dosage: 26.4 ML;QD; IV. During the same period patient was treated with METHOTREXATE, FLUDARABINE PHOSPHATE, PHENYTOIN, NEUPOGEN. Patient recovered.


Busulfan Side Effects Report #5608390-9
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Jan 11, 2008. Female patient, child 5 years of age, weighting 35.27 lb, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: coagulopathy, diarrhoea, disseminated intravascular coagulation, febrile neutropenia, hyperchloraemia, hypernatraemia, hypokalaemia, multi-organ failure, refractoriness to platelet transfusion. Busulfan dosage: 8.4 ML;X1;IV; 11.2 ML;X1;IV; 2.8 ML;X1;IV. During the same period patient was treated with CLONAZEPAM. Patient was hospitalized. Patient died on 08/27/2007.

Busulfan Side Effects Report #5196208-0
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 14, 2006. Male patient, 49 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: diarrhoea, duodenal ulcer, graft versus host disease, renal impairment. Busulfan dosage: 3.2 MG/KG;QID;IV. During the same period patient was treated with CYCLOSPORINE. Patient died on 12/05/2006.

Busulfan Side Effects Report #5391695-7
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on July 03, 2007. Male patient, 49 years of age, was diagnosed with stem cell transplant, graft versus host disease and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant rejection, cytomegalovirus infection , diarrhoea, graft complication, hyperbilirubinaemia, malaise, pain in extremity, pseudomembranous colitis. Busulfan dosage: 40 ML; QD; IV. During the same period patient was treated with NARTOGRASTIM, TRIMETHYLCETYLAMMONIUM PENTACHLOROPHENATE, CLADRIBINE, PHENYTOIN, LENOGRASTIM, FILGRASTIM, TACROLIMUS, MYCOPHENOLATE MOFETIL. Patient recovered.

Busulfan Side Effects Report #5497643-3
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 09, 2007. Male patient, 49 years of age, was diagnosed with stem cell transplant, graft versus host disease and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant rejection, central line infection, cytomegalovirus infection , diarrhoea, gamma-glutamyltransferase increased, hyperbilirubinaemia, malaise, pain in extremity. Busulfan dosage: 40 ML;QD;IV. During the same period patient was treated with NARTOGRASTIM, TRIMETHYLCETYLAMMONIUM PENTACHLOROPHENATE, CLADRIBINE, PHENYTOIN, LENOGRASTIM, NEUPOGEN, TACROLIMUS, MYCOPHENOLATE MOFETIL. Patient was hospitalized and became disabled. Patient recovered.

Busulfan Side Effects Report #5391671-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on July 03, 2007. Female patient, 48 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: abdominal pain , acute graft versus host disease, anorexia, blood bilirubin increased, bone marrow transplant , cardiac failure, diarrhoea, engraftment syndrome, gastrointestinal haemorrhage. Busulfan dosage: 5.3 ML;QID;IV. During the same period patient was treated with HEPARIN, CYCLOPHOSPHAMIDE, PHENYTOIN. Patient recovered.


Busulfan Side Effects Report #5564609-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 03, 2007. Female patient, 48 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, blood bilirubin increased, cellulitis , diarrhoea, hepatomegaly, malaise, nausea , respiratory disorder. Busulfan dosage: 30.8 ML; QD; IV. During the same period patient was treated with FLUDARABINE PHOSPHATE. Patient died on 06/05/2007.

Busulfan Side Effects Report #5663404-5
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Feb 22, 2008. Male patient, 46 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, acute myeloid leukaemia recurrent, anorexia, convulsion, diarrhoea, nausea , staphylococcal sepsis, stomatitis. Busulfan dosage: 27 ML; 36 ML; 9 ML. Patient was hospitalized. Patient died.

Busulfan Side Effects Report #5466145-2
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Sept 10, 2007. Male patient, 45 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, diarrhoea, enterococcal sepsis, pneumonia parainfluenzae viral. Busulfan dosage: 28 ML; QD; IV. During the same period patient was treated with VALPROATE, FLUDARABINE PHOSPHATE, LENOGRASTIM, TACROLIMUS, MELPHALAN. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5341121-9
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Nov 27, 2006. Female patient, 44 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: diarrhoea. Busulfan dosage: unknown. During the same period patient was treated with FLUDARABINE PHOSPHATE. Patient recovered.

Busulfan Side Effects Report #5570090-1
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 04, 2007. Female patient, 43 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bacterial sepsis, cytomegalovirus viraemia, diarrhoea, febrile neutropenia, hepatic function abnormal, hyperglycaemia, nausea , platelet count decreased. Busulfan dosage: 18.9 ML; 25.2 ML; 6.3 ML; QD; IV. During the same period patient was treated with VALPROATE. Patient was hospitalized. Patient recovered.


Busulfan Side Effects Report #5397301-X
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on July 06, 2007. Female patient, 40 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, diarrhoea, pharyngeal erythema, sepsis , stomatitis. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, METHOTREXATE, VALPROATE, FILGRASTIM, CYCLOSPORINE. Patient recovered.

Busulfan Side Effects Report #5496982-X
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 09, 2007. Female patient, child 4 years of age, weighting 35.27 lb, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, coagulopathy, diarrhoea, disseminated intravascular coagulation, febrile neutropenia, haematemesis, malaise, multi-organ failure, shock. Busulfan dosage: 4.4 MG/KG; QD; IV. Patient was hospitalized. Patient died.

Busulfan Side Effects Report #5391694-5
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on July 03, 2007. Female patient, 34 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, alanine aminotransferase increased, anorexia, aspartate aminotransferase increased, diarrhoea, enterococcal sepsis, liver disorder, malaise, nausea . Busulfan dosage: 26.8 MG;QD;IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, PHENYTOIN, FILGRASTIM, METHOTREXATE, TACROLIMUS. Patient recovered.

Busulfan Side Effects Report #5497620-2
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 09, 2007. Female patient, 34 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, alanine aminotransferase increased, anorexia, aspartate aminotransferase increased, bone marrow transplant , diarrhoea, enteritis, enterococcal sepsis, gamma-glutamyltransferase increased. Busulfan dosage: 26.8 MG;QD;IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, PHENYTOIN, NEUPOGEN, METHOTREXATE, TACROLIMUS. Patient recovered.

Busulfan Side Effects Report #5585735-X
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 21, 2007. Female patient, 32 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, acute graft versus host disease in intestine, brain abscess, cytomegalovirus viraemia, diarrhoea, haemodynamic instability, no therapeutic response, stomatitis. Busulfan dosage: 19.2 ML; XL; IV, 25.6 ML; X1; IV, 6.4 ML; X1; IV. During the same period patient was treated with MELPHALAN, FLUDARABINE PHOSPHATE, VALPROATE, ATGAM, IMMUNOGLOBULIN. Patient died on 08/20/2007.


Busulfan Side Effects Report #5413016-3
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on July 26, 2007. Male patient, 30 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, cerebellar ataxia, cytomegalovirus antigen positive, diarrhoea, gastrointestinal candidiasis, graft versus host disease, herpes zoster, malaise, small intestinal haemorrhage. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, METHOTREXATE. Patient recovered.

Busulfan Side Effects Report #5406807-6
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Aug 01, 2007. Male patient, child 3 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant rejection, diarrhoea, hyponatraemia, malaise, nausea . Busulfan dosage: 12 ML;QD;IV. During the same period patient was treated with ETOPOSIDE, CYCLOPHOSPHAMIDE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5564485-X
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 03, 2007. Male patient, 25 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, bone marrow failure, bone marrow transplant , cystitis haemorrhagic, cytomegalovirus infection , diarrhoea, malaise, nausea . Busulfan dosage: 16 ML; QD;IV, 32 ML; QD; IV. Patient recovered.

Busulfan Side Effects Report #5324444-9
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Apr 24, 2007. Male patient, 23 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, continuous haemodiafiltration, convulsion, diarrhoea, encephalitis viral, engraftment syndrome, haemorrhage, human herpesvirus 6 infection, liver disorder. Busulfan dosage: 9.4 ML; QID; IV. During the same period patient was treated with VALPROATE, FLUDARABINE PHOSPHATE, CYCLOPHOSPHAMIDE. Patient recovered.

Busulfan Side Effects Report #5447579-9
Busulfan side effect was reported by a Health Professional from JAPAN on Aug 22, 2007. Female patient, 21 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: cystitis haemorrhagic, diarrhoea, disseminated intravascular coagulation, malaise, multi-organ failure, nausea , neutropenia, staphylococcal sepsis, stem cell transplant. Busulfan dosage: 6.2 ML;BID;IV; 6.2 ML;QID;IV; 6.2 ML;X1;IV. During the same period patient was treated with PHENYTOIN, CYCLOPHOSPHAMIDE, METHOTREXATE, CYCLOSPORINE. Patient died on 05/05/2007.

Busulfan Side Effects Report #5523798-8
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Nov 05, 2007. Male patient, 21 years of age, was diagnosed with stem cell transplant, hyperbilirubinaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: diarrhoea, hyperbilirubinaemia, staphylococcal sepsis, streptococcal sepsis. Busulfan dosage: 33.2 ML; QD; IV. During the same period patient was treated with MICAFUNGIN, CYCLOPHOSPHAMIDE, VALPROATE, NEUPOGEN, METHOTREXATE, CYCLOSPORINE. Patient recovered.

Busulfan Side Effects Report #5466154-3
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Sept 10, 2007. Male patient, 20 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: altered state of consciousness, diarrhoea, gastrointestinal perforation, stress ulcer, thrombotic microangiopathy, upper gastrointestinal haemorrhage. Busulfan dosage: 31.2 ML;QD;IV; 41.6 ML;QD;IV; 10.4 ML;QD;IV. During the same period patient was treated with NEUPOGEN, VALPROATE, CYCLOPHOSPHAMIDE, METHOTREXATE, TACROLIMUS. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5585745-2
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 21, 2007. Male patient, 20 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: altered state of consciousness, diarrhoea, gastrointestinal perforation, stress ulcer, thrombotic microangiopathy, upper gastrointestinal haemorrhage. Busulfan dosage: 31.2 ML; QD; IV, 41.6 ML; QD; IV, 10.4 ML; QD; IV. During the same period patient was treated with FILGRASTIM, VALPROATE, CYCLOPHOSPHAMIDE, METHOTREXATE, TACROLIMUS. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5663698-6
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Feb 22, 2008. Male patient, 20 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute pulmonary oedema, anorexia, bradycardia, cardiac arrest , diarrhoea, enterococcal sepsis, hyperbilirubinaemia, nausea , oxygen saturation decreased. Busulfan dosage: 42.64 ML;QD;IV. During the same period patient was treated with VALPROATE, FILGRASTIM, CYCLOSPORINE, METHYLPREDNISOLONE, SUCCINATE. Patient died on 08/04/2007.

Busulfan Side Effects Report #5503593-6
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 15, 2007. Male patient, 15 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, cystitis, cystitis haemorrhagic, diarrhoea, graft versus host disease, nausea , pneumonia , sepsis , stomatitis haemorrhagic. Busulfan dosage: 27.48 ML;QD;IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, PHENYTOIN, NEUPOGEN, TACROLIMUS. Patient recovered.


Busulfan Side Effects Report #5663692-5
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Feb 22, 2008. Male patient, 15 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, cystitis haemorrhagic, diarrhoea, hepatitis b , hepatitis post transfusion, nausea , pneumonia , sepsis . Busulfan dosage: 27.48 MGL;QD;IV. During the same period patient was treated with FLUDARABINE, PHENYTOIN, FILGASTRIM, TRACROLIMUS. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5496979-X
Busulfan side effect was reported by a Health Professional from JAPAN on Oct 09, 2007. Male patient, child .8 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, bone marrow transplant , cholecystitis, diarrhoea, hypoalbuminaemia, oral intake reduced, platelet count decreased, sepsis . Busulfan dosage: 0.45 ML; X1; IV, 5.08 ML; X1; IV. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5663402-1
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on June 18, 2007. Male patient, child .5 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anaemia, anorexia, cytomegalovirus viraemia, diarrhoea, gastric haemorrhage, lymphocyte count decreased, malaise, nausea . Busulfan dosage: 1.05 ML; 2.0 ML; 2.4 ML; 0.6 ML. Patient recovered.

Busulfan Side Effects Report #5608391-0
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Jan 11, 2008. Male patient, child .4 years of age, weighting 9.04 lb, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood pressure decreased, cardiac arrest , delayed engraftment, diarrhoea, graft versus host disease, hypoglycaemia. Busulfan dosage: 1.0 MG/KG;QID;IV. During the same period patient was treated with POLYMYXIN B SULPHATE, VANCOMYCIN HYDROCHLORIDE, TAUROURSODESOXYCHOLIC ACID, FLUCONAZOLE, FLUDARABINE PHOSPHATE. Patient died on 12/02/2007.

Busulfan Side Effects Report #5607486-5
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Jan 11, 2008. Male patient was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, cellulitis , diarrhoea, escherichia sepsis, ileus, malaise, nausea , pneumonia . Busulfan dosage: 27 ML; X1; IV, 6 ML; X1; IV, 9 ML; X1, IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5832346-4
Busulfan side effect was reported by a Consumer or non-health professional from UNITED STATES on July 23, 2008. Male patient, 25 years of age, was diagnosed with bone marrow transplant  and was treated with Busulfan. After drug was administered, patient experienced the following side effects: ascites, biliary tract disorder, cytomegalovirus infection , diarrhoea, encephalopathy, enterococcal sepsis, hepatic enzyme increased, hepatic function abnormal, hepatic vein thrombosis. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE. Patient died.

Busulfan Side Effects Report #4664281-1
Busulfan side effect was reported by a Consumer or non-health professional from on Mar 31, 2005. Male patient, 61 years of age, was diagnosed with acute myeloid leukaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: diarrhoea, dysphagia, dysphonia, gastrointestinal mucositis, pharyngeal ulceration. Busulfan dosage: 130 MG/M2 EVERY DAY INTRAVENOUS. During the same period patient was treated with FLUDARABINE, THYMOGLOBULIN, AMBISOME, PENTAMIDINE, FORTUM, VANCOMYCIN, ZOVIRAX, CLONT. Patient died.

Busulfan Side Effects Report #5859263-8
Busulfan side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 26, 2008. Female patient, weighting 219.8 lb, was diagnosed with acute myeloid leukaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: diarrhoea, graft versus host disease, nausea , weight decreased. Busulfan dosage: 52 MG 16 DOSES /6 HR ORAL. During the same period patient was treated with CYCLOPHOSPHAMIDE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5951442-4
Busulfan side effect was reported by a Consumer or non-health professional from UNITED STATES on Nov 11, 2008. Female patient, weighting 155.2 lb, was diagnosed with acute myeloid leukaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: diarrhoea. Busulfan dosage: 50 MG 16X Q6HR IV. During the same period patient was treated with CYCLOPHOSPHAMIDE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #4893403-2
Busulfan side effect was reported by a Consumer or non-health professional from UNITED STATES on Jan 25, 2006. Female patient, weighting 130.1 lb, was diagnosed with acute myeloid leukaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: abdominal pain , abdominal tenderness, diarrhoea, febrile neutropenia, rash pustular, stem cell transplant, tonsillar disorder, white blood cell count decreased. Busulfan dosage: unknown. During the same period patient was treated with ETOPOSIDE. Patient was hospitalized. Patient recovered.


Busulfan Side Effects Report #5663695-0
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Feb 22, 2008. Female patient, 65 years of age, was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, blood pressure decreased, bronchiectasis, depressed level of consciousness, diarrhoea, engraftment syndrome, heart rate decreased, hypoxia, interstitial lung disease. Busulfan dosage: unknown. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, METHOTREXATE, TACROLIMUS. Patient was hospitalized. Patient died.

Busulfan Side Effects Report #6089625-8
Busulfan side effect was reported by a Consumer or non-health professional from UNITED STATES on Feb 19, 2009. Female patient, weighting 207.2 lb, was treated with Busulfan. After drug was administered, patient experienced the following side effects: abdominal adhesions, abdominal pain , anorexia, diarrhoea, enteritis, hypophagia, ileus, small intestinal obstruction, vomiting. Busulfan dosage: 784 MG. During the same period patient was treated with ETOPOSIDE. Patient was hospitalized. Patient recovered.