Busulfan and cystitis haemorrhagic Patient Reports February 12, 2012

Busulfan Side Effects Report #5269529-0
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Mar 05, 2007. Female patient, child 7 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: blood stem cell transplant failure, cystitis haemorrhagic, erythema, flushing, pigmentation disorder, skin discolouration, swelling, vomiting. Busulfan dosage: 20 MG/KG/QD; IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, ETOPOSIDE, VALPROATE, METHOTREXATE, TACROLIMUS. Patient recovered.

Busulfan Side Effects Report #5422196-5
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Aug 03, 2007. Female patient, child 7 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: bone marrow transplant rejection, bronchopulmonary aspergillosis, cystitis haemorrhagic, erythema, flushing, pigmentation disorder, staphylococcal sepsis, swelling, venoocclusive liver disease. Busulfan dosage: 20 MG/KG; QD; IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, ETOPOSIDE, VALPROATE, METHOTREXATE, TACROLIMUS. Patient recovered.

Busulfan Side Effects Report #5570101-3
Busulfan side effect was reported by a Health Professional from JAPAN on Dec 03, 2007. Male patient, 58 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, acute graft versus host disease in skin, anorexia, ascites, bk virus infection, blister, blood bilirubin increased, cystitis haemorrhagic, diarrhoea. Busulfan dosage: 31.72 ML;QD;IV. During the same period patient was treated with FLUDARABINE PHOSPHATE. Patient died on 09/11/2007.

Busulfan Side Effects Report #5269623-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Mar 08, 2007. Male patient, 54 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: cystitis haemorrhagic, graft versus host disease, thrombotic microangiopathy, venoocclusive liver disease, weight increased. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, CYCLOSPORINE, VALPROATE. Patient died on 12/19/2006.


Busulfan Side Effects Report #5299878-1
Busulfan side effect was reported by a Health Professional from JAPAN on Mar 27, 2007. Male patient, 54 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: cystitis haemorrhagic, diarrhoea, graft versus host disease, hepatic function abnormal, pyrexia, thrombotic microangiopathy, venoocclusive liver disease. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, CYCLOSPORINE, VALPROATE. Patient died on 12/19/2006.

Busulfan Side Effects Report #5385416-1
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on June 26, 2007. Male patient, 54 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: abdominal pain upper, ascites, blood bilirubin increased, blood lactate dehydrogenase increased, cystitis haemorrhagic, cytomegalovirus antibody positive, cytomegalovirus infection , diarrhoea, graft versus host disease. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, CYCLOSPORINE, VALPROATE. Patient died on 12/19/2006.

Busulfan Side Effects Report #5585749-X
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 21, 2007. Male patient, 43 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: brain stem haemorrhage, cystitis haemorrhagic, disseminated intravascular coagulation, gastrointestinal haemorrhage, infection , pulmonary haemorrhage, sepsis . Busulfan dosage: 29.32 ML; QD; IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE. Patient died on 12/17/2006.

Busulfan Side Effects Report #5586034-2
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 21, 2007. Female patient, 40 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acinetobacter infection, acute graft versus host disease, bacterial sepsis, cystitis haemorrhagic, cytomegalovirus viraemia, liver disorder, pseudomembranous colitis, staphylococcal sepsis, stomatitis. Busulfan dosage: 31.2 ML; X1; IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, PHENYTOIN. Patient was hospitalized and became disabled. Patient recovered.

Busulfan Side Effects Report #5385508-7
Busulfan side effect was reported by a Health Professional from JAPAN on June 26, 2007. Male patient, 31 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, blood bilirubin increased, blood lactate dehydrogenase increased, cystitis haemorrhagic, thrombotic microangiopathy, viraemia. Busulfan dosage: unknown. Patient was hospitalized. Patient recovered.


Busulfan Side Effects Report #5564485-X
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 03, 2007. Male patient, 25 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, bone marrow failure, bone marrow transplant , cystitis haemorrhagic, cytomegalovirus infection , diarrhoea, malaise, nausea . Busulfan dosage: 16 ML; QD;IV, 32 ML; QD; IV. Patient recovered.

Busulfan Side Effects Report #5447579-9
Busulfan side effect was reported by a Health Professional from JAPAN on Aug 22, 2007. Female patient, 21 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: cystitis haemorrhagic, diarrhoea, disseminated intravascular coagulation, malaise, multi-organ failure, nausea , neutropenia, staphylococcal sepsis, stem cell transplant. Busulfan dosage: 6.2 ML;BID;IV; 6.2 ML;QID;IV; 6.2 ML;X1;IV. During the same period patient was treated with PHENYTOIN, CYCLOPHOSPHAMIDE, METHOTREXATE, CYCLOSPORINE. Patient died on 05/05/2007.

Busulfan Side Effects Report #5503593-6
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 15, 2007. Male patient, 15 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, cystitis, cystitis haemorrhagic, diarrhoea, graft versus host disease, nausea , pneumonia , sepsis , stomatitis haemorrhagic. Busulfan dosage: 27.48 ML;QD;IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, PHENYTOIN, NEUPOGEN, TACROLIMUS. Patient recovered.

Busulfan Side Effects Report #5663692-5
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Feb 22, 2008. Male patient, 15 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, cystitis haemorrhagic, diarrhoea, hepatitis b , hepatitis post transfusion, nausea , pneumonia , sepsis . Busulfan dosage: 27.48 MGL;QD;IV. During the same period patient was treated with FLUDARABINE, PHENYTOIN, FILGASTRIM, TRACROLIMUS. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5830253-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on July 25, 2008. Male patient, 56 years of age, was diagnosed with myelodysplastic syndrome and was treated with Busulfan. After drug was administered, patient experienced the following side effects: cystitis haemorrhagic. Busulfan dosage: 4MGK CYCLIC. During the same period patient was treated with FLUDARABINE PHOSPHATE, TOTAL BODY IRRADIATION, CYCLOSPORINE, METHOTREXATE. Patient recovered.


Busulfan Side Effects Report #5213938-2
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Jan 04, 2007. Male patient, 43 years of age, was diagnosed with acute myeloid leukaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: brain stem haemorrhage, cystitis haemorrhagic, gastrointestinal haemorrhage, pulmonary haemorrhage. Busulfan dosage: 2MG/KG. During the same period patient was treated with FLUDARABINE. Patient was hospitalized. Patient died.

Busulfan Side Effects Report #5024188-7
Busulfan side effect was reported by a Consumer or non-health professional from FRANCE on July 29, 2005. Male patient, 27 years of age, was treated with Busulfan. After drug was administered, patient experienced the following side effects: cystitis haemorrhagic. Busulfan dosage: .8 MG/KG; Q6H; IV. During the same period patient was treated with CYCLOPHOSPHAMIDE. Patient was hospitalized. Patient recovered.