Busulfan and cardiac failure Patient Reports February 12, 2012

Busulfan Side Effects Report #5259878-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Feb 28, 2007. Male patient, 59 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: cardiac failure, oedema mouth, pyrexia, renal failure, stomatitis. Busulfan dosage: unknown. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5281145-3
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Mar 09, 2007. Male patient, 59 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: azotaemia, cardiac failure, disseminated intravascular coagulation, infection , multi-organ failure, oedema mouth, pyrexia, renal failure, stomatitis. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE. Patient was hospitalized. Patient died on 03/01/2007.

Busulfan Side Effects Report #5332531-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on May 07, 2007. Male patient, 59 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, antibody test positive, blood pressure decreased, capillary leak syndrome, cardiac arrest , cardiac failure, crossmatch incompatible, disseminated intravascular coagulation. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, HEPARIN. Patient was hospitalized. Patient died on 03/01/2007.

Busulfan Side Effects Report #5391672-6
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on July 02, 2007. Male patient, 59 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, capillary leak syndrome, cardiac failure, diarrhoea, disseminated intravascular coagulation, gastroenteritis staphylococcal, haemolysis, haemorrhoids, liver disorder. Busulfan dosage: 46 MG;QID;IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, HEPARIN. Patient was hospitalized. Patient died on 03/01/2007.


Busulfan Side Effects Report #5503591-2
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 15, 2007. Male patient, 59 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: azotaemia, capillary leak syndrome, cardiac arrest , cardiac failure, disseminated intravascular coagulation, gastroenteritis staphylococcal, gastrointestinal haemorrhage. Busulfan dosage: 46 MG; QID; IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, HEPARIN. Patient was hospitalized. Patient died on 03/01/2007.

Busulfan Side Effects Report #5374098-0
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on June 18, 2007. Male patient, 55 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: cardiac failure, cerebral haemorrhage, convulsion, haematoma, hypothalamo-pituitary disorder, mitral valve incompetence, nausea , oedema, pneumonia . Busulfan dosage: unknown. During the same period patient was treated with FLUDARABINE PHOSPHATE. Patient recovered.

Busulfan Side Effects Report #5497678-0
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 09, 2007. Female patient, 55 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, arthritis bacterial, cardiac failure, cytomegalovirus viraemia, diarrhoea, febrile neutropenia, hyponatraemia. Busulfan dosage: 10.6 ML;X1;IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, CYCLOSPORINE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5564611-2
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 03, 2007. Female patient, 52 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: cardiac failure, enteritis, hepatic congestion, no therapeutic response, peritonitis, pseudomembranous colitis, staphylococcal sepsis, weight increased. Busulfan dosage: 12 ML; QD; IV; 24 ML; QD; IV. Patient recovered.

Busulfan Side Effects Report #5363113-6
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on June 01, 2007. Female patient, 48 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: abdominal pain , blood bilirubin increased, bone marrow transplant , cardiac failure, engraftment syndrome, haematemesis, hepatic function abnormal, infusion related reaction, interstitial lung disease. Busulfan dosage: 5.3 ML; QID; IV. During the same period patient was treated with HEPARIN, CYCLOPHOSPHAMIDE, PHENYTOIN. Patient recovered.


Busulfan Side Effects Report #5391671-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on July 03, 2007. Female patient, 48 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: abdominal pain , acute graft versus host disease, anorexia, blood bilirubin increased, bone marrow transplant , cardiac failure, diarrhoea, engraftment syndrome, gastrointestinal haemorrhage. Busulfan dosage: 5.3 ML;QID;IV. During the same period patient was treated with HEPARIN, CYCLOPHOSPHAMIDE, PHENYTOIN. Patient recovered.

Busulfan Side Effects Report #5466200-7
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Sept 10, 2007. Female patient, 48 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, blood bilirubin increased, bone marrow transplant , cardiac failure, engraftment syndrome, gastrointestinal haemorrhage, hepatic function abnormal, hypernatraemia, interstitial lung disease. Busulfan dosage: 5.3 ML;QID;IV. During the same period patient was treated with HEPARIN, CYCLOPHOSPHAMIDE, PHENYTOIN. Patient was hospitalized. Patient died.

Busulfan Side Effects Report #5332528-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on May 07, 2007. Male patient, 47 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, cardiac failure, liver disorder, malaise, renal disorder, sepsis , staphylococcal sepsis, stem cell transplant, stomatitis. Busulfan dosage: 4 MG; QID; IV. During the same period patient was treated with MELPHALAN, CLADRIBINE, PHENYTOIN, LENOGRASTIM, CIDLOSPORIN. Patient recovered.

Busulfan Side Effects Report #5352384-8
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on May 24, 2007. Male patient, 47 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: cardiac failure, liver disorder, renal disorder, staphylococcal sepsis, stomatitis. Busulfan dosage: 4 ML; QID; IV. During the same period patient was treated with MELPHALAN, CLADRIBINE, PHENYTOIN, LENOGRASTIM, CYCLOSPORINE. Patient recovered.

Busulfan Side Effects Report #5391627-1
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on July 02, 2007. Male patient, 47 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: cardiac failure, liver disorder, renal disorder, staphylococcal sepsis, stomatitis, transplant failure. Busulfan dosage: 4 ML; QID; IV. During the same period patient was treated with MELPHALAN, CLADRIBINE, PHENYTOIN, LENOGRASTIM, CYCLOSPORINE, METHOTREXATE. Patient recovered.


Busulfan Side Effects Report #5332532-6
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on May 07, 2007. Female patient, 39 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: ascites, blood pressure decreased, cardiac failure, coagulopathy, fluid retention, hypovolaemia, pathogen resistance, pleural effusion, pseudomonas infection. Busulfan dosage: 9.5 ML; QID; IV. During the same period patient was treated with VALPROATE, CYCLOPHOSPHAMIDE, LENOGRASTIM, METHOTREXATE, TACROLIMUS, PREDNISOLONE. Patient died on 03/27/2007.