Busulfan and bone marrow transplant Patient Reports February 12, 2012

Busulfan Side Effects Report #5585758-0
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 21, 2007. Male patient, 64 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, acute myeloid leukaemia recurrent, anorexia, atrial tachycardia, atrioventricular block, bone marrow transplant , cytomegalovirus antigen positive, dysgeusia, hepatic function abnormal. Busulfan dosage: unknown. During the same period patient was treated with PHENYTOIN, NARTOGRASTIM, METHOTREXATE, TACROLIMUS, CYLOCIDE, NOVANTRONE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5586040-8
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 21, 2007. Female patient, 64 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, acute respiratory distress syndrome, bone marrow transplant , candidiasis, convulsion, disseminated intravascular coagulation, neutropenia, pancreatitis acute. Busulfan dosage: 10 ML; IV, 20 ML; IV. Patient died.

Busulfan Side Effects Report #5422205-3
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Aug 03, 2007. Male patient, 63 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, blood lactate dehydrogenase increased, bone marrow transplant , diarrhoea, febrile neutropenia, gastrointestinal disorder, haemodialysis, haemorrhagic cerebral infarction, liver disorder. Busulfan dosage: unknown. Patient recovered.

Busulfan Side Effects Report #5468640-9
Busulfan side effect was reported by a Health Professional from JAPAN on Sept 11, 2007. Male patient, 60 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: blood creatinine increased, blood culture positive, blood sodium increased, bone marrow transplant , decreased appetite, diarrhoea, escherichia infection, febrile neutropenia, haemodialysis. Busulfan dosage: 27 ML; QD; IV; 36 ML; QD; IV; 9 ML; QD; IV. During the same period patient was treated with NEUPOGEN, FLUDARABINE PHOSPHATE, CYTARABINE, VALPROATE, METHOTREXATE, TACROLIMUS. Patient died.


Busulfan Side Effects Report #5496980-6
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 09, 2007. Female patient, 52 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , diarrhoea, enterococcal sepsis, nausea , pathogen resistance, respiratory failure, staphylococcal sepsis, stomatitis. Busulfan dosage: 26.8 ML; X1; IV. During the same period patient was treated with FLUDARABINE PHOSPHATE. Patient was hospitalized and became disabled. Patient died on 08/11/2007.

Busulfan Side Effects Report #5608392-2
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Jan 11, 2008. Female patient, 51 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: bone marrow transplant , graft versus host disease, haemorrhage, herpes virus infection, liver disorder, myelodysplastic syndrome, pneumonia , respiratory depression, stomatitis. Busulfan dosage: 27.68 ML;X1;IV. During the same period patient was treated with VALPROATE, FLUDARABINE PHOSPHATE. Patient died on 07/26/2007.

Busulfan Side Effects Report #5468658-6
Busulfan side effect was reported by a Health Professional from JAPAN on Sept 11, 2007. Male patient, 50 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: bone marrow transplant , oedema, staphylococcal sepsis. Busulfan dosage: 24.6 ML; QD; IV; 32.8 ML;QD;IV; 8.2 ML;QD;IV. During the same period patient was treated with CYTARABINE, VALPROATE, CYCLOPHOSPHAMIDE, NARTOGRASTIM, METHOTREXATE, TACROLIMUS. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5363113-6
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on June 01, 2007. Female patient, 48 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: abdominal pain , blood bilirubin increased, bone marrow transplant , cardiac failure, engraftment syndrome, haematemesis, hepatic function abnormal, infusion related reaction, interstitial lung disease. Busulfan dosage: 5.3 ML; QID; IV. During the same period patient was treated with HEPARIN, CYCLOPHOSPHAMIDE, PHENYTOIN. Patient recovered.

Busulfan Side Effects Report #5391671-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on July 03, 2007. Female patient, 48 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: abdominal pain , acute graft versus host disease, anorexia, blood bilirubin increased, bone marrow transplant , cardiac failure, diarrhoea, engraftment syndrome, gastrointestinal haemorrhage. Busulfan dosage: 5.3 ML;QID;IV. During the same period patient was treated with HEPARIN, CYCLOPHOSPHAMIDE, PHENYTOIN. Patient recovered.


Busulfan Side Effects Report #5466200-7
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Sept 10, 2007. Female patient, 48 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, blood bilirubin increased, bone marrow transplant , cardiac failure, engraftment syndrome, gastrointestinal haemorrhage, hepatic function abnormal, hypernatraemia, interstitial lung disease. Busulfan dosage: 5.3 ML;QID;IV. During the same period patient was treated with HEPARIN, CYCLOPHOSPHAMIDE, PHENYTOIN. Patient was hospitalized. Patient died.

Busulfan Side Effects Report #5497620-2
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 09, 2007. Female patient, 34 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, alanine aminotransferase increased, anorexia, aspartate aminotransferase increased, bone marrow transplant , diarrhoea, enteritis, enterococcal sepsis, gamma-glutamyltransferase increased. Busulfan dosage: 26.8 MG;QD;IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, PHENYTOIN, NEUPOGEN, METHOTREXATE, TACROLIMUS. Patient recovered.

Busulfan Side Effects Report #5663693-7
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Feb 22, 2008. Male patient, 31 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, adenoviral haemorrhagic cystitis, bacterial infection , bone marrow transplant , complications of transplant surgery, cytomegalovirus antigen positive, renal failure, staphylococcal sepsis, stomatitis. Busulfan dosage: 34.0 ML;QD;IV. During the same period patient was treated with TACROLIMUS HYDRATE, CYCLOPHOSPHAMIDE, PHENYTOIN, FILGRASTIM, METHOTREXATE. Patient was hospitalized. Patient died.

Busulfan Side Effects Report #5564485-X
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 03, 2007. Male patient, 25 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, bone marrow failure, bone marrow transplant , cystitis haemorrhagic, cytomegalovirus infection , diarrhoea, malaise, nausea . Busulfan dosage: 16 ML; QD;IV, 32 ML; QD; IV. Patient recovered.

Busulfan Side Effects Report #5503594-8
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Oct 15, 2007. Female patient, 21 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: bone marrow transplant , candida sepsis, cardiogenic shock, pneumonia , staphylococcal sepsis, stomatitis. Busulfan dosage: 26 ML;QD;IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, NEUPOGEN, METHOTREXATE, TACROLIMUS. Patient recovered.


Busulfan Side Effects Report #5663691-3
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Feb 22, 2008. Female patient, 16 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , malaise, nausea , nystagmus, staphylococcal sepsis, stomatitis, vertigo. Busulfan dosage: 20 ML;QD;IV. During the same period patient was treated with PHENYTOIN, CYCLOPHOSPHAMIDE, FILGRASTIM, METHOTREXATE, TRACOLIMUS. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5564610-0
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 03, 2007. Male patient, 13 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , malaise, nausea , sepsis , stomatitis. Busulfan dosage: 24.8 ML; QD; IV. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5496979-X
Busulfan side effect was reported by a Health Professional from JAPAN on Oct 09, 2007. Male patient, child .8 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, bone marrow transplant , cholecystitis, diarrhoea, hypoalbuminaemia, oral intake reduced, platelet count decreased, sepsis . Busulfan dosage: 0.45 ML; X1; IV, 5.08 ML; X1; IV. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #4704608-5
Busulfan side effect was reported by a Consumer or non-health professional from on June 19, 2005. Male patient, 27 years of age, was diagnosed with non-hodgkin's lymphoma and was treated with Busulfan. After drug was administered, patient experienced the following side effects: bone marrow transplant , multi-organ failure, sepsis . Busulfan dosage: 108.8 MG; QD; IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, PHENYTOIN, ACYCLOVIR, TARGOCID. Patient died on 09/24/2003.

Busulfan Side Effects Report #4704591-2
Busulfan side effect was reported by a Consumer or non-health professional from on June 19, 2005. Female patient, 26 years of age, was diagnosed with lymphoma  and was treated with Busulfan. After drug was administered, patient experienced the following side effects: bone marrow transplant , multi-organ failure, sepsis . Busulfan dosage: 176 MG; QD;IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, ETOPOSIDE, PHENYTOIN. Patient died on 09/25/2003.


Busulfan Side Effects Report #4704609-7
Busulfan side effect was reported by a Consumer or non-health professional from on June 19, 2005. Female patient, 25 years of age, was diagnosed with acute myeloid leukaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: bone marrow transplant , multi-organ failure, sepsis . Busulfan dosage: 84 MG; QD; IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, FLUDARABINE, PHENYTOIN. Patient died on 04/12/2003.

Busulfan Side Effects Report #5091195-8
Busulfan side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 25, 2006. Female patient, weighting 112.4 lb, was diagnosed with acute myeloid leukaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: bone marrow transplant . Busulfan dosage: 1270 MG. Patient was hospitalized. Patient recovered.