Busulfan and blood bilirubin increased Patient Reports February 12, 2012

Busulfan Side Effects Report #5313465-8
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Apr 11, 2007. Male patient, 60 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: blood bilirubin increased, blood glucose increased, mouth haemorrhage, sepsis , stem cell transplant, stomatitis. Busulfan dosage: unknown. Patient recovered.

Busulfan Side Effects Report #5324436-X
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Apr 25, 2007. Male patient, 60 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: blood bilirubin increased, blood glucose increased, mouth haemorrhage, staphylococcal sepsis, stomatitis. Busulfan dosage: unknown. During the same period patient was treated with CYTARABINE, VALPROATE, FILGRASTIM, ETOPOSIDE. Patient recovered.

Busulfan Side Effects Report #5570101-3
Busulfan side effect was reported by a Health Professional from JAPAN on Dec 03, 2007. Male patient, 58 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, acute graft versus host disease in skin, anorexia, ascites, bk virus infection, blister, blood bilirubin increased, cystitis haemorrhagic, diarrhoea. Busulfan dosage: 31.72 ML;QD;IV. During the same period patient was treated with FLUDARABINE PHOSPHATE. Patient died on 09/11/2007.

Busulfan Side Effects Report #5385416-1
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on June 26, 2007. Male patient, 54 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: abdominal pain upper, ascites, blood bilirubin increased, blood lactate dehydrogenase increased, cystitis haemorrhagic, cytomegalovirus antibody positive, cytomegalovirus infection , diarrhoea, graft versus host disease. Busulfan dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, CYCLOSPORINE, VALPROATE. Patient died on 12/19/2006.


Busulfan Side Effects Report #5523823-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Nov 05, 2007. Female patient, 54 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: blood bilirubin increased, bronchopulmonary aspergillosis, diarrhoea, hepatic function abnormal, hypokalaemia, pancytopenia, stomatitis, streptococcal sepsis. Busulfan dosage: 24.4 ML;QD;IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, PHENYTOIN, NEUPOGEN, LENOGRASTIM, METHOTREXATE, TACROLIMUS. Patient recovered.

Busulfan Side Effects Report #5363113-6
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on June 01, 2007. Female patient, 48 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: abdominal pain , blood bilirubin increased, bone marrow transplant , cardiac failure, engraftment syndrome, haematemesis, hepatic function abnormal, infusion related reaction, interstitial lung disease. Busulfan dosage: 5.3 ML; QID; IV. During the same period patient was treated with HEPARIN, CYCLOPHOSPHAMIDE, PHENYTOIN. Patient recovered.

Busulfan Side Effects Report #5391671-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on July 03, 2007. Female patient, 48 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: abdominal pain , acute graft versus host disease, anorexia, blood bilirubin increased, bone marrow transplant , cardiac failure, diarrhoea, engraftment syndrome, gastrointestinal haemorrhage. Busulfan dosage: 5.3 ML;QID;IV. During the same period patient was treated with HEPARIN, CYCLOPHOSPHAMIDE, PHENYTOIN. Patient recovered.

Busulfan Side Effects Report #5466200-7
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Sept 10, 2007. Female patient, 48 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, blood bilirubin increased, bone marrow transplant , cardiac failure, engraftment syndrome, gastrointestinal haemorrhage, hepatic function abnormal, hypernatraemia, interstitial lung disease. Busulfan dosage: 5.3 ML;QID;IV. During the same period patient was treated with HEPARIN, CYCLOPHOSPHAMIDE, PHENYTOIN. Patient was hospitalized. Patient died.

Busulfan Side Effects Report #5564609-4
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Dec 03, 2007. Female patient, 48 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: anorexia, blood bilirubin increased, cellulitis , diarrhoea, hepatomegaly, malaise, nausea , respiratory disorder. Busulfan dosage: 30.8 ML; QD; IV. During the same period patient was treated with FLUDARABINE PHOSPHATE. Patient died on 06/05/2007.


Busulfan Side Effects Report #5385508-7
Busulfan side effect was reported by a Health Professional from JAPAN on June 26, 2007. Male patient, 31 years of age, was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, blood bilirubin increased, blood lactate dehydrogenase increased, cystitis haemorrhagic, thrombotic microangiopathy, viraemia. Busulfan dosage: unknown. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5663696-2
Busulfan side effect was reported by a Consumer or non-health professional from JAPAN on Feb 22, 2008. Male patient was diagnosed with stem cell transplant and was treated with Busulfan. After drug was administered, patient experienced the following side effects: acute graft versus host disease, alanine aminotransferase increased, altered state of consciousness, blood bilirubin increased, gamma-glutamyltransferase increased, hyperglycaemia, pleural effusion, pneumonia , renal failure. Busulfan dosage: 28 ML; IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, TACROLIMUS. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5509985-3
Busulfan side effect was reported by a Health Professional from UNITED STATES on Nov 07, 2007. Female patient, weighting 196.4 lb, was diagnosed with myeloid leukaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: abdominal pain upper, alanine aminotransferase abnormal, ammonia increased, anorexia, ascites, aspartate aminotransferase abnormal, blood bilirubin increased, confusional state, gastritis. Busulfan dosage: .08 MG/KG -56.5 MG- Q 8 H FPR 16 DOSES IV BOLUS. During the same period patient was treated with CLOFARABINE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5235918-3
Busulfan side effect was reported by a Health Professional from GERMANY on Jan 30, 2007. Female patient was diagnosed with bone marrow conditioning regimen, bone marrow transplant  and was treated with Busulfan. After drug was administered, patient experienced the following side effects: blood bilirubin increased, hepatic function abnormal, renal impairment, venoocclusive disease. Busulfan dosage: 16 MG/KG/D. During the same period patient was treated with CYCLOPHOSPHAMIDE, ATGAM, METHOTREXATE, DEFIBROTIDE, CYCLOSPORINE. Patient was hospitalized. Patient recovered.

Busulfan Side Effects Report #5235928-6
Busulfan side effect was reported by a Health Professional from GERMANY on Jan 30, 2007. Female patient was diagnosed with bone marrow conditioning regimen, bone marrow transplant  and was treated with Busulfan. After drug was administered, patient experienced the following side effects: blood bilirubin increased, disseminated intravascular coagulation, hepatic function abnormal, life support, oliguria, renal failure, respiratory failure, thrombocytopenic purpura, venoocclusive disease. Busulfan dosage: 16 MG/KG/D. During the same period patient was treated with CYCLOPHOSPHAMIDE, ATGAM, METHOTREXATE, CYCLOSPORINE. Patient was hospitalized. Patient recovered.


Busulfan Side Effects Report #5977591-2
Busulfan side effect was reported by a Consumer or non-health professional from UNITED STATES on Dec 01, 2008. Female patient, weighting 157.0 lb, was diagnosed with acute myeloid leukaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood bilirubin increased, chest discomfort, continuous haemodiafiltration, hepatic function abnormal, hypoxia, renal failure acute. Busulfan dosage: 50 MG 16X Q6HR IV. During the same period patient was treated with CYCLOPHOSPHAMIDE. Patient died on 11/27/2008.

Busulfan Side Effects Report #4744402-2
Busulfan side effect was reported by a Health Professional from UNITED STATES on Aug 11, 2005. Female patient, weighting 154.3 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Busulfan. After drug was administered, patient experienced the following side effects: asthenia, blood bilirubin increased, blood culture positive, fatigue, graft versus host disease, hypotension, nausea , neutropenia, oxygen saturation decreased. Busulfan dosage: unknown. During the same period patient was treated with CAMPATH, FLUDARABINE PHOSPHATE, PREDNISONE, ANTIBIOTICS, MORPHINE. Patient died on 08/05/2005.

Busulfan Side Effects Report #6099358-X
Busulfan side effect was reported by a Consumer or non-health professional from UNITED STATES on Feb 26, 2009. Male patient, weighting 201.3 lb, was treated with Busulfan. After drug was administered, patient experienced the following side effects: blood bilirubin increased, blood lactate dehydrogenase increased, haemolysis. Busulfan dosage: 528 MG. During the same period patient was treated with FLUDARABINE PHOSPHATE. Patient was hospitalized. Patient recovered.