Bosentan and international normalised ratio increased Patient Reports February 11, 2012

Bosentan Side Effects Report #4586772-4
Bosentan side effect was reported by a Pharmacist from on Feb 17, 2005. Male patient, 79 years of age, weighting 200.6 lb, was diagnosed with pulmonary hypertension , heart valve replacement and was treated with Bosentan. After drug was administered, patient experienced the following side effects: asthenia, decreased appetite, fluid retention, international normalised ratio increased, liver function test abnormal, malaise, pneumonia . Bosentan dosage: unknown. During the same period patient was treated with WARFARIN NOT DOCUMENTED NOT DOCUMENTED. Patient was hospitalized. Patient recovered.

Bosentan Side Effects Report #5792697-9
Bosentan side effect was reported by a Physician from UNITED STATES on June 11, 2008. Female patient, 57 years of age, weighting 110.0 lb, was diagnosed with pulmonary hypertension , cardiac valve prosthesis user and was treated with Bosentan. After drug was administered, patient experienced the following side effects: anaemia, dizziness , fatigue, illogical thinking, international normalised ratio increased, muscle spasms, palpitations, prothrombin time prolonged. Bosentan dosage: 62.5 MG, BID, ORAL. During the same period patient was treated with COUMADIN, ASPIRIN, NEXIUM, TRIAZOLAM, FERROUS SULPHATE, REQUIP, SPIRONOLACTONE, LEVOTHYROXINE. Patient was hospitalized. Patient recovered.

Bosentan Side Effects Report #4758559-0
Bosentan side effect was reported by a Physician from NETHERLANDS on Aug 22, 2005. Female patient, 23 years of age, was diagnosed with pulmonary hypertension  and was treated with Bosentan. After drug was administered, patient experienced the following side effects: gastrointestinal haemorrhage, international normalised ratio increased, liver function test abnormal. Bosentan dosage: 62.5 + 125 MG, BID, ORAL SEE IMAGE. During the same period patient was treated with MARCUMAR, IMURAN, ALENDRONATE, CALCICHEW, SINTROM MITIS, HYDROCORT. Patient was hospitalized. Patient recovered.

Bosentan Side Effects Report #4766525-4
Bosentan side effect was reported by a Physician from NETHERLANDS on Aug 29, 2005. Female patient, 23 years of age, was diagnosed with pulmonary hypertension  and was treated with Bosentan. After drug was administered, patient experienced the following side effects: abdominal pain , alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood bilirubin increased, haematemesis, international normalised ratio increased, pneumonia , retroperitoneal haematoma. Bosentan dosage: unknown. During the same period patient was treated with MARCUMAR, IMURAN, ALENDRONATE, CALCICHEW, SINTROM MITIS, HYDROCORT. Patient was hospitalized. Patient recovered.


Bosentan Side Effects Report #4777919-5
Bosentan side effect was reported by a Physician from NETHERLANDS on Sept 05, 2005. Female patient, 23 years of age, was treated with Bosentan. After drug was administered, patient experienced the following side effects: blood albumin decreased, cholangiolitis, haematocrit decreased, haemoglobin decreased, hepatitis , international normalised ratio increased, pneumonia viral, retroperitoneal haematoma, upper gastrointestinal haemorrhage. Bosentan dosage: unknown. During the same period patient was treated with MARCUMAR, ALENDRONATE, CALCICHEW, SINTROM MITIS, HYDROCORT, PREDNISOLONE. Patient was hospitalized. Patient recovered.