Bosentan and blood bilirubin increased Patient Reports February 11, 2012

Bosentan Side Effects Report #4692174-2
Bosentan side effect was reported by a Consumer or non-health professional from on June 03, 2005. Male patient, 55 years of age, was diagnosed with pulmonary hypertension  and was treated with Bosentan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood bilirubin increased, decreased appetite, gamma-glutamyltransferase increased, hepatic function abnormal, nasopharyngitis, pyrexia. Bosentan dosage: unknown. During the same period patient was treated with WARFARIN, LANIRAPID, MARZULENE, PROTECADIN. Patient was hospitalized. Patient recovered.

Bosentan Side Effects Report #4766525-4
Bosentan side effect was reported by a Physician from NETHERLANDS on Aug 29, 2005. Female patient, 23 years of age, was diagnosed with pulmonary hypertension  and was treated with Bosentan. After drug was administered, patient experienced the following side effects: abdominal pain , alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood bilirubin increased, haematemesis, international normalised ratio increased, pneumonia , retroperitoneal haematoma. Bosentan dosage: unknown. During the same period patient was treated with MARCUMAR, IMURAN, ALENDRONATE, CALCICHEW, SINTROM MITIS, HYDROCORT. Patient was hospitalized. Patient recovered.