Bosentan and aspartate aminotransferase increased Patient Reports February 11, 2012

Bosentan Side Effects Report #4913394-5
Bosentan side effect was reported by a Physician from SPAIN on Jan 31, 2006. Female patient, 73 years of age, was diagnosed with pulmonary hypertension , osteoporosis  and was treated with Bosentan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, cholangitis, jaundice cholestatic, wound . Bosentan dosage: 125 MG, BID, ORAL. During the same period patient was treated with LOSARTAN POTASSIUM, ACENOCOUMAROL, RISEDRONIC ACID. Patient was hospitalized. Patient recovered.

Bosentan Side Effects Report #4924542-5
Bosentan side effect was reported by a Physician from SPAIN on Feb 08, 2006. Female patient, 73 years of age, was diagnosed with pulmonary hypertension  and was treated with Bosentan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, bile duct obstruction, bile duct stone, biliary dilatation, blood alkaline phosphatase increased, cholangitis, jaundice cholestatic. Bosentan dosage: 125 MG, BID, ORAL. During the same period patient was treated with LOSARTAN POTASSIUM, ACENOCOUMAROL, RISEDRONIC ACID, DOMPERIDONE, FLUOXETINE, CALCIUM, OMEPRAZOLE, HYDROCHLOROTHIAZIDE. Patient was hospitalized. Patient recovered.

Bosentan Side Effects Report #4692174-2
Bosentan side effect was reported by a Consumer or non-health professional from on June 03, 2005. Male patient, 55 years of age, was diagnosed with pulmonary hypertension  and was treated with Bosentan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood bilirubin increased, decreased appetite, gamma-glutamyltransferase increased, hepatic function abnormal, nasopharyngitis, pyrexia. Bosentan dosage: unknown. During the same period patient was treated with WARFARIN, LANIRAPID, MARZULENE, PROTECADIN. Patient was hospitalized. Patient recovered.

Bosentan Side Effects Report #5211793-8
Bosentan side effect was reported by a Physician from KOREA, REPUBLIC OF on Jan 05, 2007. Female patient, 51 years of age, weighting 130.1 lb, was diagnosed with pulmonary hypertension  and was treated with Bosentan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, constipation , fatigue, gamma-glutamyltransferase increased. Bosentan dosage: unknown. Patient was hospitalized. Patient recovered.


Bosentan Side Effects Report #5196466-2
Bosentan side effect was reported by a Health Professional from KOREA, REPUBLIC OF on Dec 13, 2006. Female patient, 51 years of age, weighting 130.1 lb, was diagnosed with pulmonary hypertension  and was treated with Bosentan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, constipation , fatigue. Bosentan dosage: unknown. Patient was hospitalized. Patient recovered.

Bosentan Side Effects Report #4693817-X
Bosentan side effect was reported by a Physician from on June 08, 2005. Female patient, 39 years of age, weighting 127.9 lb, was diagnosed with pulmonary hypertension  and was treated with Bosentan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood creatine phosphokinase increased, blood lactate dehydrogenase increased, body temperature decreased, chest pain , dermatitis, disease progression, malaise. Bosentan dosage: unknown. During the same period patient was treated with PREDNISONE, DIPYRIDAMOLE, ENALAPRIL, FAMOTIDINE, JUVELA NICOTINATE, NIFEDIPINE. Patient was hospitalized. Patient recovered.

Bosentan Side Effects Report #4766525-4
Bosentan side effect was reported by a Physician from NETHERLANDS on Aug 29, 2005. Female patient, 23 years of age, was diagnosed with pulmonary hypertension  and was treated with Bosentan. After drug was administered, patient experienced the following side effects: abdominal pain , alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood bilirubin increased, haematemesis, international normalised ratio increased, pneumonia , retroperitoneal haematoma. Bosentan dosage: unknown. During the same period patient was treated with MARCUMAR, IMURAN, ALENDRONATE, CALCICHEW, SINTROM MITIS, HYDROCORT. Patient was hospitalized. Patient recovered.

Bosentan Side Effects Report #5763794-9
Bosentan side effect was reported by a Pharmacist from UNITED STATES on June 04, 2008. Male patient, weighting 15.21 lb, was diagnosed with pulmonary hypertension  and was treated with Bosentan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, pulmonary hypertension . Bosentan dosage: 15.6 MG Q12 HOURS PO. Patient recovered.