Asparaginase and grand mal convulsion Patient Reports February 13, 2012

Asparaginase Side Effects Report #5839425-6
Asparaginase side effect was reported by a Consumer or non-health professional from UNITED STATES on July 22, 2008. Male patient, child 9 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Asparaginase. After drug was administered, patient experienced the following side effects: blood creatinine increased, blood urea increased, febrile neutropenia, grand mal convulsion, ileus paralytic, paraesthesia, reversible posterior leukoencephalopathy syndrome, tumour lysis syndrome, visual impairment. Asparaginase dosage: unknown. During the same period patient was treated with VINCRISTINE, DAUNORUBICIN, PREDNISONE, METHOTREXATE. Patient was hospitalized. Patient recovered.

Asparaginase Side Effects Report #5869358-0
Asparaginase side effect was reported by a Consumer or non-health professional from LEBANON on Aug 15, 2008. Male patient, 14 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Asparaginase. After drug was administered, patient experienced the following side effects: aphasia , depressed level of consciousness, disorientation, grand mal convulsion, reversible posterior leukoencephalopathy syndrome, septic shock. Asparaginase dosage: unknown. During the same period patient was treated with DEXAMETHASONE, VINCRISTINE. Patient was hospitalized. Patient recovered.

Asparaginase Side Effects Report #5839424-4
Asparaginase side effect was reported by a Consumer or non-health professional from UNITED STATES on July 22, 2008. Female patient, child 11 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Asparaginase. After drug was administered, patient experienced the following side effects: atonic urinary bladder, febrile neutropenia, grand mal convulsion, ileus paralytic, lower motor neurone lesion, neuropathy peripheral, reversible posterior leukoencephalopathy syndrome, tardive dyskinesia. Asparaginase dosage: unknown. During the same period patient was treated with VINCRISTINE, DAUNORUBICIN, PREDNISONE, METHOTREXATE. Patient was hospitalized. Patient recovered.

Asparaginase Side Effects Report #5869359-2
Asparaginase side effect was reported by a Consumer or non-health professional from LEBANON on Aug 15, 2008. Female patient, child 11 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Asparaginase. After drug was administered, patient experienced the following side effects: drooling, eye rolling, grand mal convulsion, loss of consciousness, reversible posterior leukoencephalopathy syndrome, urinary incontinence . Asparaginase dosage: unknown. During the same period patient was treated with PREDNISONE, METHOTREXATE, DEXAMETHASONE. Patient was hospitalized. Patient recovered.