Aranesp and bone marrow failure Patient Reports February 11, 2012
Aranesp Side Effects Report #5190331-2
Aranesp side effect was reported by a Physician from UNITED STATES on Apr 11, 2006. Female patient, weighting 161.2 lb, was diagnosed with renal transplant and was treated with Aranesp. After drug was administered, patient experienced the following side effects: bone marrow failure, therapeutic response decreased. Aranesp dosage: unknown. During the same period patient was treated with PREDNISONE, PROGRAF, SENSIPAR, ASPIRIN, ACTONEL, MAGNESIUM OXIDE, VALCYTET, ATENOLOL. Patient recovered.
Aranesp Side Effects Report #4866154-8
Aranesp side effect was reported by a Physician from UNITED STATES on Dec 15, 2005. Male patient, weighting 224.2 lb, was diagnosed with renal transplant and was treated with Aranesp. After drug was administered, patient experienced the following side effects: aplasia pure red cell, atrial fibrillation
, atrial flutter, bone marrow failure, cellulitis
, coombs negative haemolytic anaemia, haemoptysis, klebsiella infection, lymphocytic leukaemia. Aranesp dosage: unknown. During the same period patient was treated with AMIODARONE, NEXIUM, SURFAK, CELEXA, ALLOPURINOL, LASIX, HYTRIN, TUSSIONEX. Patient was hospitalized. Patient recovered.Aranesp Side Effects Report #4832085-2
Aranesp side effect was reported by a Pharmacist from UNITED STATES on Nov 02, 2005. Male patient, 79 years of age, weighting 220.5 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: blood immunoglobulin m increased, bone marrow failure, chest pain
, parvovirus b19 serology positive, red blood cell sedimentation rate increased, therapeutic response decreased. Aranesp dosage: unknown. During the same period patient was treated with PROCRIT, CYCLOSPORINE, PREDNISONE, WARFARIN, CLOPIDOGREL BISULPHATE, PANTOPRAZOLE, METOPROLOL SUCCINATE, AMLODIPINE BESYLATE. Patient was hospitalized. Patient recovered.Aranesp Side Effects Report #5112448-0
Aranesp side effect was reported by a Health Professional from CANADA on Sept 11, 2006. Male patient, 69 years of age, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: anaemia, bone marrow failure, condition aggravated. Aranesp dosage: unknown. Patient recovered.
Aranesp Side Effects Report #5099960-8
Aranesp side effect was reported by a Physician from UNITED STATES on May 24, 2006. Male patient, 16 years of age, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: anaemia, aplasia, bone marrow failure. Aranesp dosage: unknown. Patient recovered.
Aranesp Side Effects Report #5236070-0
Aranesp side effect was reported by a Health Professional from UNITED STATES on Feb 05, 2007. Male patient, weighting 180.1 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, anaemia, aspartate aminotransferase increased, asthenia, bone marrow failure, burns second degree, candiduria, fall
, herpes zoster. Aranesp dosage: unknown. During the same period patient was treated with ACETAMINOPHEN, ACTONEL, ALBUTEROL, ALDACTONE, ALLOPURINOL, ASPIRIN, BECONASE AQUA, BUMEX. Patient was hospitalized. Patient recovered.Aranesp Side Effects Report #5278495-3
Aranesp side effect was reported by a Health Professional from UNITED STATES on Mar 21, 2007. Male patient, weighting 180.1 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, anaemia, aspartate aminotransferase increased, asthenia, bone marrow failure, burns second degree, candiduria, fall
, herpes zoster. Aranesp dosage: unknown. During the same period patient was treated with ACETAMINOPHEN, ACTONEL, ALBUTEROL, ALDACTONE, ALLOPURINOL, ASPIRIN, BECONASE AQUA, BUMEX. Patient was hospitalized. Patient recovered.Aranesp Side Effects Report #5295341-2
Aranesp side effect was reported by a Physician from UNITED STATES on Apr 03, 2007. Male patient, weighting 181.2 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: anaemia, bone marrow failure, decreased appetite, hepatitis b antibody, leukocytosis. Aranesp dosage: unknown. During the same period patient was treated with FOLIC ACID, VITAMIN B, PLAVIX, METOPROLOL SUCCINATE, INSULIN, ALLOPURINOL, TEMAZEPAM, LISINOPRIL. Patient was hospitalized. Patient recovered.
Aranesp Side Effects Report #5309830-5
Aranesp side effect was reported by a Physician from UNITED STATES on Apr 19, 2007. Male patient, weighting 180.1 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, anaemia, aspartate aminotransferase increased, asthenia, bone marrow failure, burns second degree, candiduria, fall
, herpes zoster. Aranesp dosage: unknown. During the same period patient was treated with ACETAMINOPHEN, ACTONEL, ALBUTEROL, ALDACTONE, ALLOPURINOL, ASPIRIN, BECONASE AQUA, BUMEX. Patient was hospitalized. Patient recovered.Aranesp Side Effects Report #5336989-6
Aranesp side effect was reported by a Physician from UNITED STATES on May 22, 2007. Male patient, weighting 181.2 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: anaemia, bone marrow failure, hepatitis b antibody, leukocytosis. Aranesp dosage: unknown. During the same period patient was treated with FOLIC ACID, VITAMIN B, PLAVIX, METOPROLOL SUCCINATE, INSULIN, ALLOPURINOL, TEMAZEPAM, LISINOPRIL. Patient was hospitalized. Patient recovered.
Aranesp Side Effects Report #5447409-5
Aranesp side effect was reported by a Physician from UNITED STATES on Aug 28, 2007. Male patient, weighting 221.1 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: anaemia, bone marrow failure. Aranesp dosage: unknown. During the same period patient was treated with PROCRIT, LASIX, DARVOCET, DOXAZOSIN MESYLATE, POTASSIUM CHLORIDE, CARDURA. Patient was hospitalized. Patient recovered.
Aranesp Side Effects Report #5598250-4
Aranesp side effect was reported by a Physician from UNITED STATES on Jan 08, 2008. Male patient, weighting 221.1 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: anaemia, bone marrow failure. Aranesp dosage: unknown. During the same period patient was treated with PROCRIT, LASIX, DARVOCET, DOXAZOSIN, POTASSIUM CHLORIDE, CARDURA. Patient was hospitalized. Patient recovered.
Aranesp Side Effects Report #5742370-8
Aranesp side effect was reported by a Physician from UNITED STATES on May 08, 2008. Male patient, weighting 181.2 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: anaemia, bone marrow failure, hepatitis b antibody, hospitalisation, leukocytosis. Aranesp dosage: unknown. During the same period patient was treated with FOLIC ACID, VITAMIN B, PLAVIX, METOPROLOL TARTRATE, INSULIN, ALLOPURINOL, TEMAZEPAM, LISINOPRIL. Patient was hospitalized. Patient recovered.
Aranesp Side Effects Report #5756931-3
Aranesp side effect was reported by a Physician from ISRAEL on May 25, 2008. Female patient, weighting 149.9 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: anaemia, bone marrow failure. Aranesp dosage: unknown. During the same period patient was treated with ACTRAPID, FUSIDIC ACID, FOLIC ACID, VENOFER, LERCANIDIPINE, LANTUS, FUROSEMIDE. Patient was hospitalized. Patient recovered.
Aranesp Side Effects Report #5839891-6
Aranesp side effect was reported by a Physician from ISRAEL on July 29, 2008. Female patient, weighting 149.9 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: anaemia, bone marrow failure. Aranesp dosage: unknown. During the same period patient was treated with ACTRAPID, FUSIDIC ACID, FOLIC ACID, VENOFER, LERCANIDIPINE, LANTUS, FRUSEMIDE. Patient was hospitalized. Patient recovered.
Aranesp Side Effects Report #5964175-5
Aranesp side effect was reported by a Physician from UNITED STATES on Nov 14, 2008. Female patient, weighting 195.8 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: aplasia pure red cell, bone marrow failure. Aranesp dosage: unknown. During the same period patient was treated with NORTRIPTYLINE, ACTONEL, ASPIRIN, CALCIUM, FLOVENT, FLUDROCORTISONE ACETATE, FOLIC ACID, FUROSEMIDE. Patient recovered.
Aranesp Side Effects Report #6047788-4
Aranesp side effect was reported by a Physician from UNITED STATES on Jan 19, 2009. Female patient, weighting 195.8 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: aplasia pure red cell, bone marrow failure. Aranesp dosage: unknown. During the same period patient was treated with NORTRIPTYLINE, ACTONEL, ASPIRIN, CALCIUM, FLOVENT, FLUDROCORTISONE ACETATE, FOLIC ACID, FUROSEMIDE. Patient recovered.
Aranesp Side Effects Report #6069744-2
Aranesp side effect was reported by a Physician from CANADA on Jan 29, 2009. Female patient, weighting 121.3 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: anaemia, anti-erythropoietin antibody positive, bone marrow failure. Aranesp dosage: unknown. During the same period patient was treated with TACROLIMUS, CELLCEPT, CALCITONIN, PREDNISONE. Patient recovered.
Aranesp Side Effects Report #6073149-8
Aranesp side effect was reported by a Physician from UNITED STATES on Feb 03, 2009. Male patient, weighting 219.1 lb, was diagnosed with renal failure chronic, anaemia and was treated with Aranesp. After drug was administered, patient experienced the following side effects: anaemia, arthritis bacterial, bone marrow failure, deep vein thrombosis
, diabetes mellitus, epistaxis, erectile dysfunction
, fall
. Aranesp dosage: unknown. During the same period patient was treated with EPOGEN, FERROUS SULPHATE, COUMADIN, MEGACE, LIPITOR, HYDRALAZINE, ASPIRIN, SULFAMETHOXAZOLE AND TRIMETHOPRIM. Patient was hospitalized. Patient recovered.Aranesp Side Effects Report #4837626-7
Aranesp side effect was reported by a Physician from CANADA on Mar 01, 2005. Male patient, weighting 105.8 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: abdominal pain
, anti-erythropoietin antibody positive, aplasia pure red cell, bone marrow failure, bone marrow toxicity, chest pain
, oesophageal ulcer, renal osteodystrophy, therapeutic response decreased. Aranesp dosage: unknown. During the same period patient was treated with ATENOLOL, NIFEDIPINE, FERROUS GLUCONATE, KAYEXALATE, CALCIUM CARBONATE, ADALAT, DIURETICS. Patient was hospitalized. Patient died on 05/08/2005.Aranesp Side Effects Report #4923389-3
Aranesp side effect was reported by a Physician from BELGIUM on July 29, 2005. Female patient, weighting 123.5 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: anaemia, aplasia pure red cell, bone marrow failure, parvovirus b19 serology positive. Aranesp dosage: unknown. During the same period patient was treated with DOLANTIN, LAMICTAL, LIPITOR, RENITEC, CALCIUM CARBONATE, VITAMINS WITH MINERALS, PHENYTOIN. Patient recovered.
Aranesp Side Effects Report #4954683-8
Aranesp side effect was reported by a Physician from GERMANY on Jan 25, 2006. Female patient, weighting 187.4 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: anaemia, bone marrow failure, nausea
, renal osteodystrophy. Aranesp dosage: unknown. During the same period patient was treated with OMEPRAL, SIMVASTATIN, FERROUS SULPHATE, TORSEMIDE, BISOPROLOL, ATACAND, ROXITHROMYCIN. Patient recovered.Aranesp Side Effects Report #4962954-4
Aranesp side effect was reported by a Physician from GERMANY on Jan 25, 2006. Female patient, weighting 187.4 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: anaemia, aplasia pure red cell, biopsy bone marrow abnormal, bone disorder, bone marrow failure, nausea
, procedural complication, renal disorder. Aranesp dosage: unknown. During the same period patient was treated with OMEPRAL, SIMVASTATIN, FERROUS SULPHATE, TORSEMIDE, BISOPROLOL, ATACAND, ROXITHROMYCIN. Patient recovered.Aranesp Side Effects Report #4993494-4
Aranesp side effect was reported by a Physician from CANADA on Mar 01, 2005. Male patient, weighting 105.8 lb, was diagnosed with renal failure chronic and was treated with Aranesp. After drug was administered, patient experienced the following side effects: abdominal pain
, anti-erythropoietin antibody positive, aplasia pure red cell, bone marrow failure, chest pain
, haemoglobin decreased, oesophageal ulcer, parvovirus b19 serology positive, therapeutic response decreased. Aranesp dosage: unknown. During the same period patient was treated with ATENOLOL, NIFEDIPINE, FERROUS GLUCONATE, KAYEXALATE, CALCIUM CARBONATE, ADALAT, DIURETICS. Patient was hospitalized. Patient died on 05/08/2005.Aranesp Side Effects Report #4874524-7
Aranesp side effect was reported by a Physician from UNITED STATES on Dec 20, 2005. Male patient, weighting 200.2 lb, was diagnosed with myelodysplastic syndrome and was treated with Aranesp. After drug was administered, patient experienced the following side effects: bone marrow failure, normochromic normocytic anaemia, treatment noncompliance. Aranesp dosage: unknown. During the same period patient was treated with HYDROXYUREA, ZYLOPRIM. Patient recovered.
Aranesp Side Effects Report #4892172-X
Aranesp side effect was reported by a Physician from UNITED STATES on Dec 20, 2005. Male patient, weighting 200.2 lb, was diagnosed with myelodysplastic syndrome and was treated with Aranesp. After drug was administered, patient experienced the following side effects: bone marrow failure. Aranesp dosage: unknown. During the same period patient was treated with HYDROXYUREA, ZYLOPRIM. Patient recovered.
Aranesp Side Effects Report #4921385-3
Aranesp side effect was reported by a Physician from UNITED STATES on Dec 20, 2005. Male patient, weighting 200.2 lb, was diagnosed with myelodysplastic syndrome and was treated with Aranesp. After drug was administered, patient experienced the following side effects: bone marrow failure, normochromic normocytic anaemia, parvovirus infection, red blood cell abnormality, refractory anaemia with an excess of blasts, thrombocythaemia, thymoma. Aranesp dosage: unknown. During the same period patient was treated with HYDROXYUREA, ZYLOPRIM. Patient recovered.
Aranesp Side Effects Report #4949396-2
Aranesp side effect was reported by a Physician from UNITED STATES on Feb 16, 2006. Female patient, weighting 126.1 lb, was diagnosed with hepatitis c
and was treated with Aranesp. After drug was administered, patient experienced the following side effects: anaemia, anti-erythropoietin antibody positive, bone marrow failure, parvovirus b19 serology positive. Aranesp dosage: unknown. During the same period patient was treated with PROCRIT, FOLIC ACID, PREMARIN, INTERFERON, VITAMIN B. Patient was hospitalized. Patient recovered.Aranesp Side Effects Report #6123120-2
Aranesp side effect was reported by a Health Professional from UNITED STATES on Mar 09, 2009. Male patient, 66 years of age, was diagnosed with dialysis
and was treated with Aranesp. After drug was administered, patient experienced the following side effects: bone marrow failure, therapeutic response decreased. Aranesp dosage: unknown. During the same period patient was treated with ASPIRIN, COUMADIN, IMURAN. Patient recovered.Aranesp Side Effects Report #5057105-4
Aranesp side effect was reported by a Physician from CANADA on Mar 22, 2006. Male patient, weighting 17.42 lb, was diagnosed with dialysis
and was treated with Aranesp. After drug was administered, patient experienced the following side effects: anaemia, bacterial infection
, blood pressure increased, bone marrow failure, catheter related complication, cough, haemodialysis, indwelling catheter management, respiratory syncytial virus infection
. Aranesp dosage: unknown. During the same period patient was treated with CALCITRIOL, FERROUS SULPHATE, CHLORIDE, RANITIDINE. Patient was hospitalized. Patient recovered.Aranesp Side Effects Report #5276959-X
Aranesp side effect was reported by a Physician from UNITED STATES on Mar 14, 2007. Male patient, weighting 156.3 lb, was diagnosed with anaemia of malignant disease and was treated with Aranesp. After drug was administered, patient experienced the following side effects: bone marrow failure, enterocolitis, escherichia bacteraemia, febrile neutropenia, multiple myeloma
, neuropathy, therapeutic response decreased. Aranesp dosage: unknown. During the same period patient was treated with FLUCONAZOLE, DAPSONE, VALTREX, BLOOD CELLS, PLATELETS, ZOMETA, ELAVIL, NEUPOGEN. Patient was hospitalized. Patient recovered.Aranesp Side Effects Report #5113704-2
Aranesp side effect was reported by a Physician from UNITED STATES on Sept 12, 2006. Male patient, weighting 191.1 lb, was diagnosed with anaemia of malignant disease and was treated with Aranesp. After drug was administered, patient experienced the following side effects: aplasia pure red cell, bone marrow failure, thrombocytopenia. Aranesp dosage: unknown. During the same period patient was treated with RITUXIMAB, BACTRIM DS, CYCLOPHOSPHAMIDE, ACYCLOVIR, ALLOPURINOL, NEURONTIN. Patient recovered.
Aranesp Side Effects Report #5135477-X
Aranesp side effect was reported by a Physician from UNITED STATES on Sept 12, 2006. Male patient, weighting 191.1 lb, was diagnosed with anaemia of malignant disease and was treated with Aranesp. After drug was administered, patient experienced the following side effects: anaemia, aplasia pure red cell, blood product transfusion dependent, bone marrow failure, chronic lymphocytic leukaemia, disease progression, reticulocytopenia, serum ferritin increased, thrombocytopenia. Aranesp dosage: unknown. During the same period patient was treated with RITUXIMAB, BACTRIM DS, CYCLOPHOSPHAMIDE, ACYCLOVIR, ALLOPURINOL, NEURONTIN. Patient recovered.
Aranesp Side Effects Report #5808578-8
Aranesp side effect was reported by a Physician from UNITED STATES on July 07, 2008. Female patient, weighting 173.1 lb, was diagnosed with anaemia of malignant disease and was treated with Aranesp. After drug was administered, patient experienced the following side effects: bone marrow failure. Aranesp dosage: unknown. During the same period patient was treated with TOPROL, ZYRTEC, TAXOTERE. Patient was hospitalized. Patient recovered.
Aranesp Side Effects Report #5825526-5
Aranesp side effect was reported by a Physician from UNITED STATES on July 22, 2008. Female patient, weighting 173.1 lb, was diagnosed with anaemia of malignant disease and was treated with Aranesp. After drug was administered, patient experienced the following side effects: bone marrow failure. Aranesp dosage: unknown. During the same period patient was treated with TOPROL, ZYRTEC, TAXOTERE. Patient was hospitalized. Patient recovered.
Aranesp Side Effects Report #5879963-3
Aranesp side effect was reported by a Physician from UNITED STATES on Sept 05, 2008. Male patient, weighting 209.2 lb, was diagnosed with anaemia of malignant disease and was treated with Aranesp. After drug was administered, patient experienced the following side effects: accelerated hypertension, anaemia, asthenia, bone marrow failure, fatigue, pancytopenia, therapeutic response decreased, ventricular tachycardia, vitamin b12 deficiency. Aranesp dosage: unknown. During the same period patient was treated with ALLOPURINOL, EXCEDRIN, NAPROXEN, METOPROLOL TARTRATE, LISINOPRIL, PEPCID, THIOTHIXENE, RITUXAN. Patient was hospitalized. Patient recovered.
Aranesp Side Effects Report #6055735-4
Aranesp side effect was reported by a Physician from UNITED STATES on Jan 23, 2009. Male patient, weighting 209.2 lb, was diagnosed with anaemia of malignant disease and was treated with Aranesp. After drug was administered, patient experienced the following side effects: accelerated hypertension, anaemia, asthenia, bone marrow failure, fatigue, pancytopenia, therapeutic response decreased, ventricular tachycardia, vitamin b12 deficiency. Aranesp dosage: unknown. During the same period patient was treated with ALLOPURINOL, EXCEDRIN, NAPROXEN, METOPROLOL TARTRATE, LISINOPRIL, PEPCID, THIOTHIXENE, RITUXAN. Patient was hospitalized. Patient recovered.
Aranesp Side Effects Report #4881943-1
Aranesp side effect was reported by a Physician from UNITED STATES on Dec 06, 2005. Female patient, weighting 160.9 lb, was diagnosed with anaemia of malignant disease and was treated with Aranesp. After drug was administered, patient experienced the following side effects: aplasia pure red cell, bone marrow failure, lung disorder, pleural effusion. Aranesp dosage: unknown. During the same period patient was treated with BACTRIM, CIPROFLOXACIN, PREDNISONE, FOLIC ACID, HEXAVITAMIN, PROTONIX, PENTAMIDINE, VORICONAZOLE. Patient was hospitalized. Patient recovered.
Aranesp Side Effects Report #5346510-4
Aranesp side effect was reported by a Physician from UNITED STATES on May 29, 2007. Male patient, weighting 75.62 lb, was diagnosed with anaemia and was treated with Aranesp. After drug was administered, patient experienced the following side effects: bone marrow failure, ocular icterus, pancytopenia, therapeutic response decreased, urine copper increased. Aranesp dosage: unknown. Patient recovered.
Aranesp Side Effects Report #5377455-1
Aranesp side effect was reported by a Physician from UNITED STATES on June 25, 2007. Male patient, weighting 75.62 lb, was diagnosed with anaemia and was treated with Aranesp. After drug was administered, patient experienced the following side effects: bone marrow failure, ocular icterus, pancytopenia, therapeutic response decreased, urine copper increased. Aranesp dosage: unknown. Patient recovered.
Aranesp Side Effects Report #4870463-6
Aranesp side effect was reported by a Physician from CANADA on Nov 15, 2005. Female patient, weighting 107.4 lb, was diagnosed with anaemia and was treated with Aranesp. After drug was administered, patient experienced the following side effects: bone marrow failure, eye allergy, infection
, mouth ulceration, therapeutic response decreased. Aranesp dosage: unknown. During the same period patient was treated with EPREX, CELLCEPT, CANDESARTAN, ACTONEL, CALCIUM GLUCONATE, AMLODIPINE, BICARBONATE, PANTOPRAZOLE. Patient was hospitalized. Patient recovered.Aranesp Side Effects Report #4917029-7
Aranesp side effect was reported by a Physician from CANADA on Nov 15, 2005. Female patient, weighting 107.4 lb, was diagnosed with anaemia and was treated with Aranesp. After drug was administered, patient experienced the following side effects: bone marrow failure, eye allergy, fungal oesophagitis, infection
, oesophageal candidiasis, therapeutic response decreased. Aranesp dosage: unknown. During the same period patient was treated with EPREX, CELLCEPT, CANDESARTAN, ACTONEL, CALCIUM GLUCONATE, AMLODIPINE, BICARBONATE, PANTOPRAZOLE. Patient was hospitalized. Patient recovered.
Aranesp and bone marrow failure 