Ambisome and liver disorder Patient Reports February 12, 2012

Ambisome Side Effects Report #5572342-8
Ambisome side effect was reported by a Physician from JAPAN on Dec 06, 2007. Female patient, 72 years of age, was diagnosed with systemic candida and was treated with Ambisome. After drug was administered, patient experienced the following side effects: anaemia, condition aggravated, hepatic function abnormal, juvenile arthritis, liver disorder, renal disorder, renal failure. Ambisome dosage: 250 MG, UID/QD, IV DRIP. During the same period patient was treated with PREDONINE, BENAMBAX, MAXIPIME, CEFTRIAXONE. Patient died on 08/03/2007.

Ambisome Side Effects Report #5739691-1
Ambisome side effect was reported by a Health Professional from JAPAN on Apr 24, 2008. Male patient, 59 years of age, was diagnosed with febrile neutropenia and was treated with Ambisome. After drug was administered, patient experienced the following side effects: anaemia, blood bilirubin increased, blood creatinine decreased, blood urea increased, body temperature increased, hypokalaemia, liver disorder, platelet count decreased. Ambisome dosage: 50 MG, UID/QD IV NOS; 100 MG, UID/QD; IV NOS. During the same period patient was treated with VANCOMYCIN HYDROCHLORIDE, MAXIPIME, PROGRAF, POTASSIUM CHLORIDE, INTRALIPOS, MEROPEN, PRIMAXIN. Patient recovered.

Ambisome Side Effects Report #5691892-7
Ambisome side effect was reported by a Health Professional from JAPAN on Mar 14, 2008. Male patient, 58 years of age, was diagnosed with febrile neutropenia and was treated with Ambisome. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, anaemia, aspartate aminotransferase increased, blood bilirubin increased, blood urea increased, c-reactive protein increased, hypokalaemia, liver disorder, platelet count decreased. Ambisome dosage: 50 MG, UID/QD, IV NOS; 100 MG, UID/QD, IV NOS. During the same period patient was treated with VANCOMYCIN HYDROCHLORIDE, MAXIPIME, PROGRAF, POTASSIUM CHLORIDE, INTRALIPOS, MEROPEN. Patient recovered.

Ambisome Side Effects Report #5584674-8
Ambisome side effect was reported by a Health Professional from JAPAN on Dec 18, 2007. Female patient, 79 years of age, was diagnosed with bronchopulmonary aspergillosis and was treated with Ambisome. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, liver disorder. Ambisome dosage: 76 MG, UID/QD, IV NOS. During the same period patient was treated with CEFAZOLIN. Patient recovered.


Ambisome Side Effects Report #5594020-1
Ambisome side effect was reported by a Health Professional from JAPAN on Dec 28, 2007. Female patient, 79 years of age, was diagnosed with bronchopulmonary aspergillosis and was treated with Ambisome. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, aspiration, blood alkaline phosphatase increased, hypokalaemia, liver disorder, pyrexia. Ambisome dosage: 76 MG, UID/QD, IV NOS. During the same period patient was treated with CEFAZOLIN. Patient recovered.

Ambisome Side Effects Report #5632034-3
Ambisome side effect was reported by a Health Professional from JAPAN on Jan 28, 2008. Female patient, 79 years of age, was diagnosed with bronchopulmonary aspergillosis and was treated with Ambisome. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, aspiration, blood alkaline phosphatase increased, haematocrit decreased, haemoglobin decreased, hypokalaemia, liver disorder, pyrexia. Ambisome dosage: 76 MG, UID/QD, IV NOS. During the same period patient was treated with CEFAZOLIN. Patient recovered.

Ambisome Side Effects Report #5635678-8
Ambisome side effect was reported by a Health Professional from JAPAN on Feb 06, 2008. Female patient, 79 years of age, was diagnosed with bronchopulmonary aspergillosis and was treated with Ambisome. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, haematocrit decreased, haemoglobin decreased, hypokalaemia, liver disorder, pyrexia, white blood cell count increased. Ambisome dosage: 76 MG, UID/QD, IV NOS. During the same period patient was treated with CEFAZOLIN. Patient recovered.

Ambisome Side Effects Report #5859031-7
Ambisome side effect was reported by a Health Professional from JAPAN on Dec 18, 2007. Female patient, 79 years of age, was diagnosed with bronchopulmonary aspergillosis and was treated with Ambisome. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood creatinine decreased, haemoglobin decreased, hypokalaemia, liver disorder, pyrexia, red blood cell count decreased. Ambisome dosage: 76 MG, UID/QD, IV NOS. During the same period patient was treated with CEFAZOLIN. Patient recovered.

Ambisome Side Effects Report #5903382-4
Ambisome side effect was reported by a Physician from JAPAN on Sept 18, 2008. Male patient, 77 years of age, weighting 142.6 lb, was diagnosed with bronchopulmonary aspergillosis, thrombocytopenic purpura and was treated with Ambisome. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, antithrombin iii deficiency, aspartate aminotransferase increased, bronchopulmonary aspergillosis, cytomegalovirus infection , haemodialysis, hyperkalaemia, liver disorder, pneumonia . Ambisome dosage: 3.9 MGKG, UID/QD, IV NOS; 200 MG, UID/QD, IV NOS. During the same period patient was treated with DECADRON, DIFLUCAN, FUNGUARD, MAXIPIME, VFEND, GANCICLOVIR, POLYGLOBIN. Patient was hospitalized. Patient died on 10/14/2007.


Ambisome Side Effects Report #6029357-5
Ambisome side effect was reported by a Consumer or non-health professional from JAPAN on Dec 22, 2008. Male patient, 76 years of age, weighting 121.7 lb, was diagnosed with bronchopulmonary aspergillosis and was treated with Ambisome. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, anaemia, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood lactate dehydrogenase increased, blood potassium decreased, creatinine renal clearance decreased, liver disorder, pyrexia. Ambisome dosage: 125 MG, UID/QD, IV NOS; 250 MG, UID/QD,IV NOS; 200 MG, UID/QD, IV NOS;. During the same period patient was treated with FUNGUARD, GANCICLOVIR, HARNAL, LAC B, MAGNESIUM OXIDE. Patient recovered.

Ambisome Side Effects Report #6055087-X
Ambisome side effect was reported by a Health Professional from JAPAN on Jan 09, 2009. Male patient, 76 years of age, weighting 121.7 lb, was diagnosed with bronchopulmonary aspergillosis and was treated with Ambisome. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, anaemia, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood lactate dehydrogenase increased, blood potassium decreased, creatinine renal clearance decreased, liver disorder, pyrexia. Ambisome dosage: 125 MG, UID/QD, IV NOS; 250 MG, UID/QD, IV NOS; 200 MG, UID/QD, IV NOS; 250 MG, UID/QD, IV NOS. During the same period patient was treated with FUNGUARD, GANCICLOVIR, HARNAL, LAC B, MAGNESIUM OXIDE. Patient recovered.

Ambisome Side Effects Report #5766316-1
Ambisome side effect was reported by a Physician from JAPAN on May 22, 2008. Male patient, 45 years of age, was diagnosed with bronchopulmonary aspergillosis and was treated with Ambisome. After drug was administered, patient experienced the following side effects: hypocalcaemia, hypokalaemia, liver disorder, rhabdomyolysis, tuberculosis . Ambisome dosage: 200 MG, UID/QD, IV NOS. During the same period patient was treated with RIFAMPICIN, ITRAZOL, CODEINE SUL, MUCODYNE. Patient was hospitalized. Patient recovered.

Ambisome Side Effects Report #5792672-4
Ambisome side effect was reported by a Physician from JAPAN on June 13, 2008. Male patient, 45 years of age, was diagnosed with bronchopulmonary aspergillosis and was treated with Ambisome. After drug was administered, patient experienced the following side effects: hypocalcaemia, hypokalaemia, liver disorder, rhabdomyolysis. Ambisome dosage: 200 MG, UID/QD, IV NOS. During the same period patient was treated with RIFAMPICIN, ITRAZOL, CODEINE SUL, MUCODYNE. Patient was hospitalized. Patient recovered.

Ambisome Side Effects Report #5874624-9
Ambisome side effect was reported by a Physician from JAPAN on Aug 20, 2008. Male patient, 45 years of age, was diagnosed with bronchopulmonary aspergillosis and was treated with Ambisome. After drug was administered, patient experienced the following side effects: hypokalaemia, liver disorder, rhabdomyolysis. Ambisome dosage: 200 MG, UID/QD, IV NOS. During the same period patient was treated with RIFAMPICIN, ITRAZOL, CODEINE PHOSPHATE, MUCODYNE. Patient was hospitalized. Patient recovered.


Ambisome Side Effects Report #5468150-9
Ambisome side effect was reported by a Health Professional from JAPAN on Sept 10, 2007. Male patient, 33 years of age, was diagnosed with bronchopulmonary aspergillosis and was treated with Ambisome. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, cardio-respiratory arrest, liver disorder. Ambisome dosage: 140 MG, UID/QD, IV DRIP. During the same period patient was treated with VFEND, DECADRON, ERYTHROCIN, CELLCEPT, BAKTAR, LASIX, AMIKACIN SULPHATE, MAXIPME. Patient died on 06/30/2007.

Ambisome Side Effects Report #5491414-X
Ambisome side effect was reported by a Physician from JAPAN on Oct 02, 2007. Male patient, 33 years of age, was diagnosed with bronchopulmonary aspergillosis and was treated with Ambisome. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood lactate dehydrogenase increased, cardio-respiratory arrest, condition aggravated, depressed level of consciousness, liver disorder, lung infiltration. Ambisome dosage: 140 MG, UID/QD, IV DRIP. During the same period patient was treated with VFEND, DECADRON, ERYTHROCIN, CELLCEPT, BAKTAR, LASIX, AMIKACIN SULPHATE, MAKIPIME. Patient died on 06/30/2007.

Ambisome Side Effects Report #5928847-0
Ambisome side effect was reported by a Consumer or non-health professional from JAPAN on Oct 09, 2008. Female patient, 32 years of age, was diagnosed with bronchopulmonary aspergillosis and was treated with Ambisome. After drug was administered, patient experienced the following side effects: haemorrhage, ileus paralytic, liver disorder. Ambisome dosage: 150 MG, UID/QD, IV NOS. During the same period patient was treated with FAMOTIDINE, CIPROFLOXACIN, VANCOMYCIN HYDROCHLORIDE, LENDORM, BIOFERMIN R, SULFAMETHOXAZOLE AND TRIMETHOPRIM, ITRACONAZOLE, MEDICON. Patient died on 09/03/2007.

Ambisome Side Effects Report #5939493-7
Ambisome side effect was reported by a Health Professional from JAPAN on Oct 21, 2008. Female patient, 32 years of age, was diagnosed with bronchopulmonary aspergillosis and was treated with Ambisome. After drug was administered, patient experienced the following side effects: blood bilirubin increased, blood urea decreased, haematocrit decreased, haemoglobin decreased, haemorrhage, liver disorder, platelet count decreased, red blood cell count decreased, white blood cell count decreased. Ambisome dosage: 150 MG, UID/QD, IV NOS. During the same period patient was treated with FAMOTIDINE, CIPROFLOXACIN, VANCOMYCIN HYDROCHLORIDE, LENDORM, BIOFERMIN R, SULFAMETHOXAZOLE AND TRIMETHOPRIM, ITRACONAZOLE, MEDICON. Patient died.

Ambisome Side Effects Report #5955715-0
Ambisome side effect was reported by a Health Professional from JAPAN on Oct 28, 2008. Female patient, 32 years of age, was diagnosed with bronchopulmonary aspergillosis and was treated with Ambisome. After drug was administered, patient experienced the following side effects: blood bilirubin increased, blood urea decreased, haemorrhage, liver disorder. Ambisome dosage: 150 MG, UID/QD, IV NOS. During the same period patient was treated with FAMOTIDINE, CIPROFLOXACIN, VANCOMYCIN HYDROCHLORIDE, LENDORM, BIOFERMIN R, SULFAMETHOXAZOLE AND TRIMETHOPRIM, ITRACONAZOLE, MEDICON. Patient died on 09/03/2007.


Ambisome Side Effects Report #5759318-2
Ambisome side effect was reported by a Health Professional from JAPAN on May 07, 2008. Male patient, 60 years of age, weighting 114.6 lb, was diagnosed with brain abscess, lymphoma  and was treated with Ambisome. After drug was administered, patient experienced the following side effects: central nervous system lymphoma, depressed level of consciousness, dysphagia, hypotension, liver disorder. Ambisome dosage: 150 MG, UID/QD, APPROX 28.7MG/KG. During the same period patient was treated with MEROPENEM TRIHYDRATE, VANCOMYCIN HYDROCHLORIDE, ANCOTIL, FAMOTIDINE, ENTERONON R, TEGRETOL, PROMAC, LOXONIN. Patient died on 08/26/2007.

Ambisome Side Effects Report #5827695-X
Ambisome side effect was reported by a Health Professional from JAPAN on July 10, 2008. Male patient, 60 years of age, weighting 114.6 lb, was diagnosed with brain abscess, lymphoma  and was treated with Ambisome. After drug was administered, patient experienced the following side effects: brain cancer metastatic, central nervous system lymphoma, dysphagia, hypotension, liver disorder. Ambisome dosage: 150 MG, UID/QD, APPROX 28.7MG/KG. During the same period patient was treated with MEROPENEM TRIHYDRATE, VANCOMYCIN HYDROCHLORIDE, ANCOTIL, FAMOTIDINE, ENTERONON R, TEGRETOL, PROMAC, LOXONIN. Patient died on 08/21/2007.

Ambisome Side Effects Report #5909752-2
Ambisome side effect was reported by a Health Professional from JAPAN on July 10, 2008. Male patient, 60 years of age, weighting 114.6 lb, was diagnosed with brain abscess, lymphoma  and was treated with Ambisome. After drug was administered, patient experienced the following side effects: brain neoplasm malignant, depressed level of consciousness, dysphagia, hypotension, liver disorder. Ambisome dosage: 150 MG, UID/QD, APPROX 28.7MG/KG, IV NOS. During the same period patient was treated with MEROPENEM TRIHYDRATE, VANCOMYCIN HYDROCHLORIDE, ANCOTIL, GASTER D, ENTERONON R, TEGRETOL, PROMAC, LOXONIN. Patient died on 08/21/2007.