Alteplase and coma Patient Reports February 12, 2012

Alteplase Side Effects Report #4716953-8
Alteplase side effect was reported by a Consumer or non-health professional from UNITED STATES on June 29, 2005. Male patient, 47 years of age, was diagnosed with thrombosis in device, clonus and was treated with Alteplase. After drug was administered, patient experienced the following side effects: basilar artery thrombosis, brain herniation, brain oedema, brain stem syndrome, carotid artery occlusion, cerebral haemorrhage, cerebral infarction, coma, corneal reflex decreased. Alteplase dosage: INTERMITTENT THROMBOLYSIS DOSES RANGING FROM 50 TO 100 MG (NR, INTERMITTENT THROMBOLYSIS), IV. During the same period patient was treated with ASPIRIN, MIDAZOLAM, WARFARIN, CLOPIDOGREL BISULPHATE, HEPARIN, PHOSPHENYTOIN. Patient died.

Alteplase Side Effects Report #5732784-4
Alteplase side effect was reported by a Pharmacist from UNITED STATES on May 07, 2008. Female patient, 80 years of age, was diagnosed with cerebrovascular accident and was treated with Alteplase. After drug was administered, patient experienced the following side effects: agitation, aphasia , apnoeic attack, areflexia, cerebral haemorrhage, cerebrovascular accident, coma, hypertension. Alteplase dosage: unknown. During the same period patient was treated with CLOPIDOGREL, ASPIRIN. Patient died.

Alteplase Side Effects Report #4636553-8
Alteplase side effect was reported by a Health Professional from on Apr 14, 2005. Male patient, 75 years of age, weighting 149.9 lb, was diagnosed with cerebrovascular accident and was treated with Alteplase. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, coma, hypoxia, injury, interstitial lung disease, ischaemia, lung disorder, movement disorder , respiratory failure. Alteplase dosage: 61.2MG ONE HOUR INTRAVENOU. Patient was hospitalized and became disabled. Patient recovered.