Alteplase and brain oedema Patient Reports February 12, 2012

Alteplase Side Effects Report #4716953-8
Alteplase side effect was reported by a Consumer or non-health professional from UNITED STATES on June 29, 2005. Male patient, 47 years of age, was diagnosed with thrombosis in device, clonus and was treated with Alteplase. After drug was administered, patient experienced the following side effects: basilar artery thrombosis, brain herniation, brain oedema, brain stem syndrome, carotid artery occlusion, cerebral haemorrhage, cerebral infarction, coma, corneal reflex decreased. Alteplase dosage: INTERMITTENT THROMBOLYSIS DOSES RANGING FROM 50 TO 100 MG (NR, INTERMITTENT THROMBOLYSIS), IV. During the same period patient was treated with ASPIRIN, MIDAZOLAM, WARFARIN, CLOPIDOGREL BISULPHATE, HEPARIN, PHOSPHENYTOIN. Patient died.

Alteplase Side Effects Report #5004057-9
Alteplase side effect was reported by a Pharmacist from UNITED STATES on May 15, 2006. Female patient, 86 years of age, weighting 194.7 lb, was diagnosed with ischaemic stroke and was treated with Alteplase. After drug was administered, patient experienced the following side effects: apnoea, atrial fibrillation , blood pressure increased, brain oedema, disease progression, haemorrhage intracranial, haemorrhagic stroke, loss of consciousness, pneumonia aspiration. Alteplase dosage: 71.2 MG 1 TIME IV. During the same period patient was treated with AMITRIPTYLINE, LEVOXYL, NIFEDIPINE, AMBIEN, LASIX. Patient died on 04/25/2006.

Alteplase Side Effects Report #5940712-1
Alteplase side effect was reported by a Physician from UNITED STATES on Nov 03, 2008. Female patient, weighting 17.64 lb, was diagnosed with catheter related complication and was treated with Alteplase. After drug was administered, patient experienced the following side effects: brain abscess, brain oedema, brain stem infarction, cerebellar infarction, cerebral infarction, meningitis , subdural empyema. Alteplase dosage: 0.77 MG, Q 1 HR, IV. During the same period patient was treated with FOSPHENYTOIN, MAGNESIUM SULPHATE, COLACE, FAMOTIDINE, HEPARIN, CEFOTAXIME. Patient died on 10/28/2008.