Allopurinol and hepatic failure Patient Reports February 10, 2012

Allopurinol Side Effects Report #4849707-2
Allopurinol side effect was reported by a Physician from SPAIN on Nov 22, 2005. Male patient, 80 years of age, was diagnosed with hyperuricaemia and was treated with Allopurinol. After drug was administered, patient experienced the following side effects: cholestasis, eosinophil percentage increased, granulomatous liver disease, hepatic encephalopathy, hepatic failure, hepatomegaly, incorrect dose administered. Allopurinol dosage: 300 MG QDAY. During the same period patient was treated with PREDNISONE, OMEPRAZOLE, FUROSEMIDE. Patient was hospitalized. Patient died.

Allopurinol Side Effects Report #4868588-4
Allopurinol side effect was reported by a Consumer or non-health professional from SPAIN on Dec 19, 2005. Male patient, 80 years of age, was diagnosed with hyperuricaemia and was treated with Allopurinol. After drug was administered, patient experienced the following side effects: hepatic encephalopathy, hepatic failure, hypersensitivity. Allopurinol dosage: unknown. During the same period patient was treated with OMEPRAZOLE, FUROSEMIDE. Patient died.

Allopurinol Side Effects Report #4911390-5
Allopurinol side effect was reported by a Physician from JAPAN on Jan 27, 2006. Male patient, 68 years of age, was diagnosed with hyperuricaemia and was treated with Allopurinol. After drug was administered, patient experienced the following side effects: hepatic enzyme increased, hepatic failure, lymphadenopathy, lymphocyte morphology abnormal, neutrophilia, pneumonia , proteinuria, renal impairment, toxic epidermal necrolysis. Allopurinol dosage: unknown. Patient was hospitalized. Patient died.

Allopurinol Side Effects Report #5907508-8
Allopurinol side effect was reported by a Health Professional from UNITED KINGDOM on Sept 17, 2008. Male patient, 84 years of age, was diagnosed with gout  and was treated with Allopurinol. After drug was administered, patient experienced the following side effects: hepatic failure. Allopurinol dosage: 100 MG, BID, ORAL. During the same period patient was treated with ASPIRIN, BISOPROLOL FUMARATE, FUROSEMIDE, OMEPRAZOLE, PREDNISONE. Patient was hospitalized. Patient recovered.


Allopurinol Side Effects Report #4980381-0
Allopurinol side effect was reported by a Pharmacist from UNITED STATES on Apr 21, 2006. Female patient, 80 years of age, weighting 122.0 lb, was diagnosed with gout  and was treated with Allopurinol. After drug was administered, patient experienced the following side effects: hepatic failure, jaundice , pruritus, pyrexia, rash erythematous, renal function test abnormal, tachycardia. Allopurinol dosage: 300MG ONCE DAILY? PO. Patient was hospitalized. Patient died on 04/18/2006.

Allopurinol Side Effects Report #4963489-5
Allopurinol side effect was reported by a Pharmacist from UNITED STATES on Apr 04, 2006. Female patient, 67 years of age, weighting 290.0 lb, was diagnosed with gout  and was treated with Allopurinol. After drug was administered, patient experienced the following side effects: asterixis, blood creatinine increased, exfoliative rash, fatigue, hepatic failure, hypotension, orthostatic hypotension. Allopurinol dosage: 400 MG QDAY. During the same period patient was treated with ADVAIR DISKUS, GLYBURIDE, ISOSORBID MONONITRATE, NYSTATIN, CLOPIDOGREL, ACARBOSE, LANSOPRAZOLE, FUROSEMIDE. Patient died on 03/30/2006.

Allopurinol Side Effects Report #4965709-X
Allopurinol side effect was reported by a Pharmacist from UNITED STATES on Apr 05, 2006. Female patient, 67 years of age, weighting 290.0 lb, was diagnosed with gout  and was treated with Allopurinol. After drug was administered, patient experienced the following side effects: asterixis, blood creatinine increased, exfoliative rash, fatigue, hepatic failure, orthostatic hypotension. Allopurinol dosage: 400 MG Q DAY. During the same period patient was treated with ADVAIR DISKUS, GLYBURIDE, ISOSORBIDE MONONOTRATE, NYSTATIN, CLOPIDOGREL, ACARBOSE, LANSOPRAZOLE, FUROSEMIDE. Patient died on 03/30/2006.

Allopurinol Side Effects Report #5513882-7
Allopurinol side effect was reported by a Consumer or non-health professional from UNITED STATES on Nov 09, 2007. Female patient, 34 years of age, weighting 219.0 lb, was diagnosed with gout  and was treated with Allopurinol. After drug was administered, patient experienced the following side effects: hepatic failure, renal failure. Allopurinol dosage: unknown. Patient was hospitalized. Patient recovered.

Allopurinol Side Effects Report #4639980-8
Allopurinol side effect was reported by a Consumer or non-health professional from on Apr 15, 2005. Female patient, 34 years of age, weighting 220.0 lb, was diagnosed with gout  and was treated with Allopurinol. After drug was administered, patient experienced the following side effects: dry skin, epistaxis, hepatic failure, influenza, malaise, renal failure. Allopurinol dosage: unknown. Patient was hospitalized. Patient recovered.


Allopurinol Side Effects Report #4677137-5
Allopurinol side effect was reported by a Consumer or non-health professional from on May 25, 2005. Female patient, weighting 210.1 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Allopurinol. After drug was administered, patient experienced the following side effects: abdominal distension, cholestasis, hepatic cirrhosis, hepatic failure, liver disorder, nausea , sepsis , urine output decreased. Allopurinol dosage: 300 MG PO QD ON DAYS 1 - 14. During the same period patient was treated with CYCLOPHOSPHAMIDE, DAUNORUBICIN, VINCRISTINE, DEXAMETHASONE, NEUPOGEN, METHOTREXATE, CYTARABINE. Patient recovered.

Allopurinol Side Effects Report #4673151-4
Allopurinol side effect was reported by a Consumer or non-health professional from on May 19, 2005. Male patient, 54 years of age, was diagnosed with stem cell transplant, pancytopenia and was treated with Allopurinol. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, ascites, blood alkaline phosphatase increased, blood bilirubin increased, blood cholinesterase decreased, haemosiderosis, hepatic atrophy, hepatic failure, hepatic function abnormal. Allopurinol dosage: unknown. During the same period patient was treated with SULFAMETHOXAZOLE AND TRIMETHOPRIM, CYCLOSPORINE, TRANSFUSIONS. Patient died.