Aldurazyme and respiratory failure Patient Reports February 12, 2012

Aldurazyme Side Effects Report #5500334-3
Aldurazyme side effect was reported by a Physician from GERMANY on Oct 10, 2007. Female patient, child 6 years of age, weighting 39.68 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: ascites, pneumonia , respiratory failure. Aldurazyme dosage: unknown. Patient was hospitalized. Patient died on 09/27/2007.

Aldurazyme Side Effects Report #6020710-2
Aldurazyme side effect was reported by a Physician from MEXICO on Dec 08, 2008. Male patient, child 6 years of age, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: adenoidal hypertrophy, cardiomyopathy , respiratory failure, sleep apnoea syndrome. Aldurazyme dosage: 0.58 MG/KG, 1X/W, INTRAVENOUS. During the same period patient was treated with CAPTOPRIL, FUROSEMIDE, ESPIRONOLACTONA. Patient died on 12/07/2008.

Aldurazyme Side Effects Report #6065428-5
Aldurazyme side effect was reported by a Physician from BRAZIL on Jan 19, 2009. Male patient, child 6 years of age, weighting 44.09 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: gastroenteritis , respiratory failure, sinusitis , tachycardia. Aldurazyme dosage: unknown. Patient was hospitalized. Patient recovered.

Aldurazyme Side Effects Report #5390730-X
Aldurazyme side effect was reported by a Physician from UNITED STATES on Dec 20, 2005. Female patient, child 5 years of age, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: dyspnoea, pyrexia, respiratory failure, speech disorder, viral infection , vomiting. Aldurazyme dosage: 0.6 MG/KG QWK IV. Patient was hospitalized. Patient died on 12/19/2005.


Aldurazyme Side Effects Report #4673960-1
Aldurazyme side effect was reported by a Physician from on May 09, 2005. Male patient, child 5 years of age, weighting 47.18 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: bronchopneumonia, respiratory failure. Aldurazyme dosage: unknown. During the same period patient was treated with ENARENAL, BERODUAL, PULMICORT. Patient was hospitalized. Patient recovered.

Aldurazyme Side Effects Report #4874096-7
Aldurazyme side effect was reported by a Physician from UNITED STATES on Dec 20, 2005. Female patient, child 5 years of age, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: dyspnoea, pyrexia, respiratory failure, speech disorder, viral infection , vomiting. Aldurazyme dosage: 0.6 MG/KG QWK IV. Patient was hospitalized. Patient died on 12/19/2005.

Aldurazyme Side Effects Report #5912126-1
Aldurazyme side effect was reported by a Physician from BRAZIL on Sept 20, 2008. Male patient, 42 years of age, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: blood pressure decreased, cardiac disorder, endotracheal intubation complication, influenza, renal failure, respiratory failure. Aldurazyme dosage: unknown. Patient was hospitalized. Patient died on 09/15/2008.

Aldurazyme Side Effects Report #5390761-X
Aldurazyme side effect was reported by a Physician from BRAZIL on Apr 20, 2005. Female patient, child 4 years of age, weighting 31.31 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: respiratory failure. Aldurazyme dosage: 1.2 MG/KG QWK IV. During the same period patient was treated with DIFENIDIRAMINE, ACETAMINOPHEN, AMOXICILLIN, PHENOTEROL, AMBROSAL, DIPIRONE. Patient died on 04/14/2005.

Aldurazyme Side Effects Report #6050039-8
Aldurazyme side effect was reported by a Physician from UNITED STATES on Jan 12, 2009. Male patient, 31 years of age, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: abdominal hernia, abdominal hernia gangrenous, apnoea, intestinal perforation, post procedural complication, respiratory failure, small intestinal obstruction. Aldurazyme dosage: 31 MG, INTRAVENOUS. During the same period patient was treated with PREDTE. Patient was hospitalized. Patient recovered.


Aldurazyme Side Effects Report #6058006-5
Aldurazyme side effect was reported by a Physician from UNITED STATES on Jan 15, 2009. Male patient, 31 years of age, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: abdominal hernia, inguinal hernia, intestinal perforation, respiratory failure, small intestinal obstruction, small intestine gangrene. Aldurazyme dosage: 31 MG, UNK, INTRAVENOUS. During the same period patient was treated with PREDTE. Patient was hospitalized. Patient recovered.

Aldurazyme Side Effects Report #5389824-4
Aldurazyme side effect was reported by a Physician from BRAZIL on Jan 24, 2007. Male patient, child 3 years of age, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: anaesthetic complication pulmonary, ear infection , respiratory failure, sinusitis . Aldurazyme dosage: unknown. Patient was hospitalized. Patient recovered.

Aldurazyme Side Effects Report #5390954-1
Aldurazyme side effect was reported by a Health Professional from UNITED STATES on Sept 11, 2006. Female patient, child 3 years of age, weighting 31.75 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: graft versus host disease, respiratory failure. Aldurazyme dosage: 0.25 MG/KG QWK IV. Patient died on 09/04/2006.

Aldurazyme Side Effects Report #4673957-1
Aldurazyme side effect was reported by a Health Professional from on May 06, 2005. Male patient, 23 years of age, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: chronic sinusitis, pulmonary hypertension , respiratory failure, right ventricular failure, sleep apnoea syndrome. Aldurazyme dosage: 23.2 MG/KG 1XW IV. During the same period patient was treated with ALBUTEROL. Patient was hospitalized. Patient recovered.

Aldurazyme Side Effects Report #5704295-3
Aldurazyme side effect was reported by a Physician from BRAZIL on Mar 26, 2008. Female patient, child 11 years of age, weighting 48.50 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: cor pulmonale, pneumonia aspiration, respiratory failure. Aldurazyme dosage: 58 MG, Q4W, INTRAVENOUS; 58 MG, Q4W, INTRAVENOUS. During the same period patient was treated with FUROSEMIDE, DIGOXIN, CAPTOPRIL. Patient died on 01/29/2008.


Aldurazyme Side Effects Report #5294481-1
Aldurazyme side effect was reported by a Physician from UNITED STATES on Mar 23, 2007. Male patient was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: post procedural complication, respiratory failure. Aldurazyme dosage: 8.7 MG QWK IV. Patient died on 03/22/2007.

Aldurazyme Side Effects Report #5480861-8
Aldurazyme side effect was reported by a Physician from UKRAINE on Sept 20, 2007. Female patient, weighting 33.07 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: bronchitis chronic, condition aggravated, cyanosis, loss of consciousness, neurological symptom, pneumonia , procedural complication, respiratory failure. Aldurazyme dosage: 1 MG/KG 1XW IV. During the same period patient was treated with SUMAMED. Patient died on 09/18/2007.

Aldurazyme Side Effects Report #5603252-5
Aldurazyme side effect was reported by a Physician from BRAZIL on Jan 07, 2008. Male patient was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: cardio-respiratory arrest, ear infection , no therapeutic response, refusal of treatment by relative, respiratory disorder, respiratory failure, sinusitis . Aldurazyme dosage: 1.2 MG/KG, QW, INTRAVENOUS; 0.58 MG/KG, QW, INTRAVENOUS. Patient was hospitalized. Patient died on 06/01/2007.

Aldurazyme Side Effects Report #5775436-7
Aldurazyme side effect was reported by a Health Professional from UNITED STATES on May 29, 2008. Female patient, weighting 31.75 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: graft versus host disease, renal failure acute, respiratory failure. Aldurazyme dosage: 0.58 MG/KG, QW, INTRAVENOUS. Patient died on 09/04/2006.

Aldurazyme Side Effects Report #5941650-0
Aldurazyme side effect was reported by a Physician from UNITED STATES on Oct 20, 2008. Male patient, weighting 21.38 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: cytomegalovirus infection , pneumonitis, respiratory failure. Aldurazyme dosage: 0.58 MG/KG, Q2W. Patient died on 09/25/2008.


Aldurazyme Side Effects Report #5776069-9
Aldurazyme side effect was reported by a Physician from PORTUGAL on May 30, 2008. Female patient, 18 years of age, weighting 70.55 lb, was diagnosed with mucopolysaccharidosis and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: cardiac failure, cardio-respiratory arrest, disease progression, pulmonary hypertension , respiratory failure. Aldurazyme dosage: unknown. During the same period patient was treated with FUROSEMIDE, ESPIRONOLACTONA. Patient died on 05/23/2008.