Aldurazyme and graft versus host disease Patient Reports February 12, 2012

Aldurazyme Side Effects Report #5390712-8
Aldurazyme side effect was reported by a Physician from SPAIN on Apr 17, 2007. Female patient, child 5 years of age, weighting 30.86 lb, was diagnosed with mucopolysaccharidosis ih and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: graft versus host disease, stem cell transplant. Aldurazyme dosage: unknown. During the same period patient was treated with STEROIDS, ANTIBIOTICS, ANTIFUNGALS, DOPAMINE, CYCLOSPORINE, MYCOPHENOLATE MOFETIL. Patient died on 10/18/2006.

Aldurazyme Side Effects Report #5390954-1
Aldurazyme side effect was reported by a Health Professional from UNITED STATES on Sept 11, 2006. Female patient, child 3 years of age, weighting 31.75 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: graft versus host disease, respiratory failure. Aldurazyme dosage: 0.25 MG/KG QWK IV. Patient died on 09/04/2006.

Aldurazyme Side Effects Report #5390724-4
Aldurazyme side effect was reported by a Physician from NETHERLANDS on Mar 24, 2006. Female patient was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: bone marrow transplant , graft versus host disease, transplant failure. Aldurazyme dosage: unknown. Patient died.

Aldurazyme Side Effects Report #5390758-X
Aldurazyme side effect was reported by a Physician from NETHERLANDS on Mar 24, 2006. Male patient was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: candida sepsis, graft versus host disease. Aldurazyme dosage: unknown. Patient died on 05/15/2005.


Aldurazyme Side Effects Report #5390762-1
Aldurazyme side effect was reported by a Physician from CANADA on July 15, 2005. Female patient, weighting 24.00 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: acute graft versus host disease in intestine, acute graft versus host disease in skin, bronchopulmonary aspergillosis, dystrophic calcification, fungal infection , obliterative bronchiolitis, pancreatitis, pneumonia . Aldurazyme dosage: unknown. During the same period patient was treated with PREDNISONE. Patient died on 11/21/2004.

Aldurazyme Side Effects Report #5775436-7
Aldurazyme side effect was reported by a Health Professional from UNITED STATES on May 29, 2008. Female patient, weighting 31.75 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: graft versus host disease, renal failure acute, respiratory failure. Aldurazyme dosage: 0.58 MG/KG, QW, INTRAVENOUS. Patient died on 09/04/2006.

Aldurazyme Side Effects Report #4622679-1
Aldurazyme side effect was reported by a Physician from on Mar 04, 2005. Female patient was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: graft versus host disease. Aldurazyme dosage: 0.58 MG/KG QWK IV. During the same period patient was treated with BUSULFAN, CYCLOPHOSPHAMIDE, FLUDARABINE PHOSPHATE. Patient was hospitalized. Patient recovered.

Aldurazyme Side Effects Report #4629255-5
Aldurazyme side effect was reported by a Health Professional from on Mar 22, 2005. Male patient, weighting 24.25 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: constipation , graft versus host disease. Aldurazyme dosage: 5.8 MG QWK IV. Patient was hospitalized. Patient recovered.

Aldurazyme Side Effects Report #4685191-X
Aldurazyme side effect was reported by a Physician from on May 18, 2005. Male patient was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: graft versus host disease, stem cell transplant. Aldurazyme dosage: unknown. Patient died on 05/15/2005.


Aldurazyme Side Effects Report #4848747-7
Aldurazyme side effect was reported by a Physician from SPAIN on Oct 20, 2005. Female patient was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: bacteraemia, graft versus host disease, hepatotoxicity, hyperthermia, therapeutic agent toxicity, urinary tract infection . Aldurazyme dosage: unknown. During the same period patient was treated with ANTIHISTAMINE SEDATIVE, ANTIPYRETIC. Patient was hospitalized. Patient recovered.