Aldurazyme and dyspnoea Patient Reports February 12, 2012

Aldurazyme Side Effects Report #6065420-0
Aldurazyme side effect was reported by a Physician from ARGENTINA on Jan 16, 2009. Female patient, child 9 years of age, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: cyanosis, dyspnoea, face oedema, infusion related reaction, oxygen saturation decreased, rash , tongue oedema. Aldurazyme dosage: 11.6 MG, 1X/W, INTRAVENOUS. Patient recovered.

Aldurazyme Side Effects Report #5832244-6
Aldurazyme side effect was reported by a Physician from CHILE on July 17, 2008. Male patient, child 7 years of age, weighting 39.68 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: dyspnoea, erythema, face oedema, tongue oedema. Aldurazyme dosage: 0.58 MG/KG, 1X/W, INTRAVENOUS. Patient recovered.

Aldurazyme Side Effects Report #6081440-4
Aldurazyme side effect was reported by a Physician from UNITED STATES on Feb 05, 2009. Female patient, child 6 years of age, weighting 40.12 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: asthenia, bradycardia, cardio-respiratory arrest, catheter related complication, cough, dyspnoea, hydrocephalus , hypoxia, infusion site oedema. Aldurazyme dosage: 8.7 MG, 1X/W, INTRAVENOUS. During the same period patient was treated with DIPHENHYDRAMINE, ACETAMINOPHNE, HEPARIN. Patient died.

Aldurazyme Side Effects Report #5292543-6
Aldurazyme side effect was reported by a Health Professional from UNITED STATES on Mar 19, 2007. Male patient, child 5 years of age, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: abdominal pain , blood pressure diastolic decreased, cough, dyspnoea, eye swelling, face oedema, infusion related reaction, oxygen saturation decreased. Aldurazyme dosage: 8.7 MG QWK IV. During the same period patient was treated with HYDROCORTISONE, BENADRYL. Patient recovered.


Aldurazyme Side Effects Report #5297533-5
Aldurazyme side effect was reported by a Physician from COLOMBIA on Mar 21, 2007. Male patient, child 5 years of age, weighting 33.07 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: cyanosis, diarrhoea, dyspnoea, pyrexia, tachypnoea, tremor, vomiting. Aldurazyme dosage: 0.58 MG/KG QWK IV. During the same period patient was treated with LEVOTIROXINE, LORATADINE. Patient recovered.

Aldurazyme Side Effects Report #5390730-X
Aldurazyme side effect was reported by a Physician from UNITED STATES on Dec 20, 2005. Female patient, child 5 years of age, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: dyspnoea, pyrexia, respiratory failure, speech disorder, viral infection , vomiting. Aldurazyme dosage: 0.6 MG/KG QWK IV. Patient was hospitalized. Patient died on 12/19/2005.

Aldurazyme Side Effects Report #4848119-5
Aldurazyme side effect was reported by a Physician from UNITED STATES on Nov 15, 2005. Female patient, child 5 years of age, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: dyspnoea, malaise, po2 decreased, pyrexia, viral infection , vomiting. Aldurazyme dosage: unknown. Patient was hospitalized. Patient recovered.

Aldurazyme Side Effects Report #4874096-7
Aldurazyme side effect was reported by a Physician from UNITED STATES on Dec 20, 2005. Female patient, child 5 years of age, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: dyspnoea, pyrexia, respiratory failure, speech disorder, viral infection , vomiting. Aldurazyme dosage: 0.6 MG/KG QWK IV. Patient was hospitalized. Patient died on 12/19/2005.

Aldurazyme Side Effects Report #5390241-1
Aldurazyme side effect was reported by a Physician from FRANCE on Oct 19, 2006. Male patient, child 4 years of age, weighting 37.48 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: agitation, dyspnoea, erythema, oxygen saturation decreased, urticaria, wheezing. Aldurazyme dosage: unknown. During the same period patient was treated with TELFAST. Patient was hospitalized. Patient recovered.


Aldurazyme Side Effects Report #5390989-9
Aldurazyme side effect was reported by a Physician from UNITED STATES on Mar 01, 2007. Female patient, 39 years of age, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: dyspnoea, infusion related reaction, oxygen saturation decreased, pyrexia, wheezing. Aldurazyme dosage: 0.58 MG/KG QWK IV. During the same period patient was treated with TYLENOL, CLARITIN. Patient recovered.

Aldurazyme Side Effects Report #5390194-6
Aldurazyme side effect was reported by a Physician from BRAZIL on Nov 30, 2006. Male patient, 13 years of age, weighting 55.89 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: dyspnoea, hypersensitivity, urticaria. Aldurazyme dosage: 25.5 ML QWK IV. Patient was hospitalized. Patient recovered.

Aldurazyme Side Effects Report #5920980-2
Aldurazyme side effect was reported by a Physician from BRAZIL on Oct 01, 2008. Male patient, child 11 years of age, weighting 101.4 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: dyspnoea, infusion related reaction, tachycardia, tachypnoea, urticaria. Aldurazyme dosage: 23.2 MG, 1X/W, INTRAVENOUS. Patient recovered.

Aldurazyme Side Effects Report #4666358-3
Aldurazyme side effect was reported by a Health Professional from on Apr 26, 2005. Male patient, weighting 77.16 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: arthralgia, cardio-respiratory distress, dyspnoea, hypoxia, knee deformity, wheezing. Aldurazyme dosage: 0.58 MG/KG QWK IV. During the same period patient was treated with SALBUTAMOL, BUDESONIDE, IBUPROFEN. Patient was hospitalized. Patient recovered.

Aldurazyme Side Effects Report #4680237-7
Aldurazyme side effect was reported by a Health Professional from on May 17, 2005. Female patient, weighting 68.78 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: asthenia, dyspnoea, hydrocephalus . Aldurazyme dosage: 8.7 MG QWK IV. Patient was hospitalized. Patient recovered.


Aldurazyme Side Effects Report #4707219-0
Aldurazyme side effect was reported by a Health Professional from on June 14, 2005. Female patient, weighting 68.78 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: asthenia, dyspnoea, hydrocephalus . Aldurazyme dosage: 8.7 MG QWK IV. Patient was hospitalized. Patient recovered.

Aldurazyme Side Effects Report #6071856-4
Aldurazyme side effect was reported by a Health Professional from UNITED STATES on Jan 23, 2009. Female patient, child 6 years of age, weighting 30.42 lb, was diagnosed with mucopolysaccharidosis and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: asthenia, catheter related complication, catheter site swelling, dyspnoea, hydrocephalus , hypoxia, pneumonia , respiratory arrest, respiratory distress. Aldurazyme dosage: 8.6 MG, 1X/W, INTRAVENOUS. During the same period patient was treated with DIPHENHYDRAMINE, ACETAMINOPHEN, HEPARIN. Patient died.

Aldurazyme Side Effects Report #4764193-9
Aldurazyme side effect was reported by a Health Professional from UNITED STATES on July 19, 2005. Female patient, 30 years of age, weighting 68.00 lb, was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: dyspnoea, oedema peripheral. Aldurazyme dosage: 17.4 MG IV. During the same period patient was treated with LASIX. Patient recovered.