Aldurazyme and disease progression Patient Reports February 12, 2012

Aldurazyme Side Effects Report #5920977-2
Aldurazyme side effect was reported by a Physician from GERMANY on Sept 30, 2008. Male patient, 46 years of age, weighting 141.1 lb, was diagnosed with mucopolysaccharidosis is and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: bedridden, condition aggravated, disease progression, pain , refusal of treatment by patient, spinal column stenosis. Aldurazyme dosage: unknown. During the same period patient was treated with AMIODARONE, MORPHINE, HALOPERIDOL. Patient died on 09/17/2008.

Aldurazyme Side Effects Report #5390725-6
Aldurazyme side effect was reported by a Physician from FRANCE on May 02, 2006. Male patient, child 4 years of age, weighting 35.94 lb, was diagnosed with mucopolysaccharidosis ih and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: bradycardia, bronchial disorder, cardiac arrest , condition aggravated, disease progression, ear congestion, ear disorder, hypercapnia. Aldurazyme dosage: 14.5 MG QWK IV. During the same period patient was treated with VENTOLIN. Patient was hospitalized. Patient died on 03/17/2006.

Aldurazyme Side Effects Report #5036467-8
Aldurazyme side effect was reported by a Physician from FRANCE on June 09, 2006. Male patient, child 4 years of age, weighting 35.94 lb, was diagnosed with mucopolysaccharidosis ih and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: bradycardia, bronchopneumonia, bronchopneumopathy, cardiac arrest , condition aggravated, disease progression, hypercapnia, mucopolysaccharidosis ih, obstructive airways disorder. Aldurazyme dosage: 14.5 MG QWK IV. During the same period patient was treated with VENTOLIN. Patient was hospitalized. Patient died on 03/17/2006.

Aldurazyme Side Effects Report #5390757-8
Aldurazyme side effect was reported by a Physician from BRAZIL on Nov 28, 2005. Female patient, child 6 years of age, weighting 28.97 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: abasia, disease progression, heart rate increased, respiratory rate increased. Aldurazyme dosage: 1.2 MG/KG QOW;IV. During the same period patient was treated with BACTRIM, TYENOL, DIPIRONE, CHAMOMILE, TRANSPULMIN. Patient recovered.


Aldurazyme Side Effects Report #4738225-8
Aldurazyme side effect was reported by a Physician from BRAZIL on July 06, 2005. Female patient, child 6 years of age, weighting 28.97 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: abasia, disease progression, mucopolysaccharidosis i. Aldurazyme dosage: 1.2 MG/KG QOW IV. During the same period patient was treated with BACTRIM, TYLENOL, DIPIRONE, CHAMOMILE, TRANSPULMIN. Patient recovered.

Aldurazyme Side Effects Report #5855986-5
Aldurazyme side effect was reported by a Physician from UNITED STATES on Aug 08, 2008. Male patient, 18 years of age, weighting 198.4 lb, was diagnosed with mucopolysaccharidosis i, headache , neck pain and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: congestive cardiomyopathy, disease progression, headache , hypersensitivity, infusion related reaction, intracranial pressure increased, myocardial fibrosis, neck pain. Aldurazyme dosage: 1.74 MG, ONCE, INTRATHECAL; INTRAVENOUS. During the same period patient was treated with DURAGESIC, BENADRYL, ADVIL. Patient died on 01/26/2008.

Aldurazyme Side Effects Report #6111312-8
Aldurazyme side effect was reported by a Physician from UNITED KINGDOM on Feb 25, 2009. Female patient, 18 years of age, weighting 87.96 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: disease progression, mitral valve replacement. Aldurazyme dosage: unknown. During the same period patient was treated with VENTOLIN, BECONASE, BACLOFEN. Patient died on 02/01/2009.

Aldurazyme Side Effects Report #5390734-7
Aldurazyme side effect was reported by a Physician from FRANCE on Oct 07, 2005. Female patient, 17 years of age, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: areflexia, arrhythmia supraventricular, cardiac disorder, cerebral atrophy, depressed level of consciousness, disease progression, dyspnoea exertional, escherichia sepsis, fluid retention. Aldurazyme dosage: 1 MG/KG 1XW;IV. Patient was hospitalized. Patient recovered.

Aldurazyme Side Effects Report #5894574-1
Aldurazyme side effect was reported by a Physician from BRAZIL on Sept 10, 2008. Female patient, 17 years of age, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: cardiac failure, disease progression. Aldurazyme dosage: 0.58 MG/KG, 1X/W, INTRAVENOUS. Patient died on 09/01/2008.


Aldurazyme Side Effects Report #5878837-1
Aldurazyme side effect was reported by a Health Professional from UNITED STATES on Aug 27, 2008. Female patient, child 11 years of age, weighting 44.09 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: disease progression, multi-organ failure. Aldurazyme dosage: 14.5 MG, 1X/W; INTRAVENOUS. Patient died on 05/21/2008.

Aldurazyme Side Effects Report #5600001-1
Aldurazyme side effect was reported by a Health Professional from UNITED STATES on Jan 03, 2008. Female patient, weighting 24.91 lb, was diagnosed with mucopolysaccharidosis i and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: disease progression, mucopolysaccharidosis ih, stem cell transplant. Aldurazyme dosage: 5.8 MG, QW, INTRAVENOUS. During the same period patient was treated with BENADRYL, ACETAMINOPHEN. Patient died on 10/31/2007.

Aldurazyme Side Effects Report #5776069-9
Aldurazyme side effect was reported by a Physician from PORTUGAL on May 30, 2008. Female patient, 18 years of age, weighting 70.55 lb, was diagnosed with mucopolysaccharidosis and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: cardiac failure, cardio-respiratory arrest, disease progression, pulmonary hypertension , respiratory failure. Aldurazyme dosage: unknown. During the same period patient was treated with FUROSEMIDE, ESPIRONOLACTONA. Patient died on 05/23/2008.

Aldurazyme Side Effects Report #6081686-5
Aldurazyme side effect was reported by a Physician from UNITED KINGDOM on Feb 03, 2009. Female patient, 18 years of age, was diagnosed with mucopolysaccharidosis and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: disease progression, mucopolysaccharidosis i. Aldurazyme dosage: unknown. Patient died on 02/01/2009.

Aldurazyme Side Effects Report #5675952-2
Aldurazyme side effect was reported by a Health Professional from UNITED STATES on Mar 05, 2008. Female patient, child 11 years of age, weighting 44.09 lb, was diagnosed with mucopolysaccharidosis and was treated with Aldurazyme. After drug was administered, patient experienced the following side effects: disease progression, mucopolysaccharidosis i. Aldurazyme dosage: 14.5 MG, 1X/W, INTRAVENOUS. Patient recovered.