Activase and brain herniation Patient Reports February 11, 2012

Activase Side Effects Report #6018120-7
Activase side effect was reported by a Health Professional from GERMANY on Dec 16, 2008. Male patient, 70 years of age, was diagnosed with pulmonary embolism  and was treated with Activase. After drug was administered, patient experienced the following side effects: brain herniation, cardiogenic shock, haemorrhage intracranial. Activase dosage: unknown. During the same period patient was treated with UROKINASE, HEPARIN. Patient died.

Activase Side Effects Report #4928639-5
Activase side effect was reported by a Pharmacist from UNITED STATES on Feb 27, 2006. Male patient, 61 years of age, weighting 187.0 lb, was diagnosed with pulmonary embolism  and was treated with Activase. After drug was administered, patient experienced the following side effects: brain compression, brain herniation, cerebral haematoma, cerebral haemorrhage, confusional state, hemiparesis, intracranial pressure increased. Activase dosage: 100MG OVER 2 HOURS IV. Patient was hospitalized. Patient recovered.

Activase Side Effects Report #5304468-8
Activase side effect was reported by a Physician from JAPAN on Apr 18, 2007. Male patient, 65 years of age, was diagnosed with cerebral artery embolism and was treated with Activase. After drug was administered, patient experienced the following side effects: brain herniation. Activase dosage: 30.7 ML, SINGLE. During the same period patient was treated with ASPIRIN. Patient was hospitalized. Patient recovered.

Activase Side Effects Report #5312783-7
Activase side effect was reported by a Physician from JAPAN on Apr 18, 2007. Male patient, 65 years of age, was diagnosed with cerebral artery embolism and was treated with Activase. After drug was administered, patient experienced the following side effects: brain herniation. Activase dosage: 30.7 ML, SINGLE. During the same period patient was treated with ASPIRIN. Patient was hospitalized. Patient recovered.